Defeated by an initial project on in vitro fertilization in mice, he had switched to studying
how yeast cells duplicate their genome during cell division.
fertilization in mice, he had switched to studying
how yeast cells duplicate their genome during cell division.
Verstrepen first got an idea that this might be going on about 15 years ago as a graduate student studying
how yeast cells contribute to the flavor of beer and wine.
A research group at the Buchmann Institute for Molecular Life Sciences (BMLS) of Goethe University in Frankfurt, together with colleagues at the Max Planck Institute of Biophysics, has now discovered
how yeast cells measure the availability of saturated and unsaturated fatty acids in foodstuffs and adapt their production of membrane lipids to it.
Not exact matches
The early stage research involves mice and
yeast and centers on
how diet affects aging and health and
how cell aging leads to
cell breakdowns.
«It's possible that some of these same mechanisms that we've seen in
yeast may be influencing the amount of damage that is forming and
how quickly it is repaired in human
cells,» he said.
Researchers in this study used budding
yeast, creating populations of
cells with more than 10 million different randomised genomes, to investigate
how genetic diversity affected resistance.
But while this study has proved that the technique works in a simple organism, it could also be applied to other bacterial species,
yeast or even human
cells to find useful information about
how genes are controlled and
how they can be manipulated.
Though little is known about Loki, scientists hope that it will help to resolve one of biology's biggest mysteries:
how life transformed from simple single -
celled organisms to the menagerie of complex life known as eukaryotes — a category that includes everything from
yeast to azaleas to elephants.
For
yeast, reproduction is life, so both methods measure a
yeast cell's life span by the number of progeny it generates, rather than
how long it remains metabolically active.
The team first used the tried - and - true method of growing
yeast in Petri dishes and painstakingly counting
how many times an individual
yeast cell produced a daughter
cell.
Even simple baker's
yeast, which consists of only one
cell to our billions, is playing a role in studies of
how cancer treatments work.
To determine which strains yielded increased lifespan, the researchers counted
yeast cells, logging
how many daughter
cells a mother produced before it stopped dividing.
We used
yeast — a system easily accessible genetically — and asked the question
how does one part of the
cell know what is going on in another part.
We study
how genetic, environmental and regulatory factors affect the chronological lifespan of quiescent
yeast cells.
Lundblad's group has engineered
yeast cells that lack telomerase, to study
how cells respond to eroding telomeres when telomerase is not present to counter-balance.
Understanding
how yeast cope with osmotic stress is useful to understand
how human
cells respond to medical treatments, but the principles are also applicable to many other fields, including agriculture.
CAMBRIDGE, Mass. — New research into a family of
cell wall proteins shows
how yeast can present a variety of «faces» to its environment.
New research into a family of
cell wall proteins shows
how yeast can present a variety of «faces» to its environment.
By combining the fission
yeast, mouse, and human systems with the latest genomic, genetic,
cell biological, and biochemical approaches, we seek to determine
how condensin and cohesin organize the functional 3D genome structures and participate in various biological processes, including transcriptional regulation and chromosomal dynamics, and
how they contribute to oncogenic processes.
Swanton was stunned to learn
how similar fundamental cellular processes were between humans and
yeast, and
how cell - cycle regulation is related to cancer development.