Sentences with phrase «human htt»

The BAC (Bacterial Artificial Chromosome) mouse model of Huntington's disease expresses the full length human htt transgene and has been well - characterized for its progressively impaired motor function.

Our data indicates that human htt ameliorates the cognitive deficits observed in the KD mice.

By combining SNP - targeting allele - specific silencing and gain - of - function approaches, we showed that a 46 - glutamine expansion in human HTT was sufficient for a dominant - negative effect on spindle orientation and changes in the distribution within the spindle pole and the cell cortex of dynein, p150Glued and NuMA in neural cells.

HD is caused by a mutation in the human HTT gene that results in an abnormal expansion and misfolding of the corresponding huntingtin protein.

Not exact matches

If HTT can prove that humans can be transported safely at such speeds, it could provoke others, including governments, to invest in making Musk's plans a reality.

They used the gene editing technology CRISPR to engineer a series of human embryonic stem cell lines, which were identical apart from the number of DNA repeats that occurred at the ends of their HTT genes.

Next we these tools to explore how mutations in the HTT protein impact on human cortical development and human neuronal and astroglial functions.

Thus, neural derivatives of disease - specific human pluripotent stem cells constitute a relevant biological resource for exploring the impact of adult - onset HD mutations of the HTT gene on the division of neural progenitors, with potential applications in HD drug discovery targeting HTT - dynein - p150Glued complex interactions.

Humans have two copies of the HTT gene, HD happens when a mutation makes one copy too big.

Adults who had been categorized as behaviorally inhibited at the age of 2 years exhibited a higher amygdala activation in response to unknown vs familiar faces16 compared with adults who were uninhibited as children, consistent with the notion that novel or ambiguous environmental stimuli of potential biological relevance activate the amygdala.17 Turning to genes that can influence the neurobiological bases of the processing of emotions, 2 common alleles, the short (S) and the long (L), in a variable repeat sequence of the serotonin transporter (5 - HTT) promoter polymorphism (5 - HTTLPR) on human chromosome 17q11 have been differently associated with greater amygdala activity in response to angry or fearful faces18 in healthy adults.

In addition to cultural factors, human behaviour is influenced by specific genes, such as the serotonin transporter gene (SLC6A4), which regulates serotonergic neurotransmission (5 - HTT)(Lesch et al. 1996; Canli & Lesch 2007).