Human diseases that include dyskeratosis congenita, aplastic anemia, and idiopathicpulmonaryfibrosis have been genetically linked to mutations that negatively affect telomerase activity and / or accelerate the loss of telomere length.
The hedgehog system machinery controls transforming growth factor - ß - dependent myofibroblastic differentiation in humans: involvement in idiopathicpulmonaryfibrosis.