Sentences with phrase «human adenoviral»

In animal models, E1 - deleted human adenoviral recombinants of the serotype 5 (AdHu5) have shown high efficacy as vaccine carriers.

The closest human adenoviral relatives were the species D adenoviruses, which share 54.3 % to 55.1 % identity to TMAdV, with human adenoviruses of other species slightly less similar (51.1 % — 54.6 %).

However, the high sequence divergence in the fiber protein (Table 2), as well as the absence of fiber motifs conserved among adenoviruses that bind CAR [36], [37](coxsackievirus - adenovirus receptor) or CD46 [38], [39], [40](data not shown), suggest that neither of these two human adenoviral receptors may be the attachment receptor for TMAdV.

Not exact matches

The high degree of sequence relatedness within members of each species suggests that at least some adenoviral strains may be capable of infecting both nonhuman primates and humans.

In the current work we used adenoviral - type 5 (dE1 / E3)(Cytomegalovirus promoter) with human ABCA10 transgene (Ad - h - ABCA10) purchased from Vector Labs ® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin.

Lack of preexisting virus - neutralizing antibodies in the human population suggests that these novel adenoviral recombinants may provide improved vaccine carriers for use in humans.

Adenoviral vectors can be produced by human embryonic kidney (HEK293) and human embryonic retinal (PER.C6) cell lines (31), both of which also can be used for lentiviral vector production.

Both vectors are human serotype 5, replication - defective, first generation adenoviral vectors deleted in E1a and E3 viral encoding regions.