Sentences with phrase «human adenovirus»

The phrase "human adenovirus" refers to a type of virus that can infect humans. It is a small organism that can make people sick, causing symptoms like a cold, fever, or even more serious illnesses. Full definition
Characterization of a variant of human adenovirus type 2 which multiples efficiently in simian cells
In group two, eight children with unexplained fevers were tested; standard testing found 11 viruses, the new test found an additional seven, including the respiratory virus human adenovirus B type 3A.
Partial block to transcription of human adenovirus type 2 late genes in abortively infected monkey cells
Second, our results show that PCR assays for human adenoviruses in common use are capable of detecting TMAdV.
Isolation of a variant of human adenovirus serotype 2 that multiplies efficiently on monkey cells
The closest human adenoviral relatives were the species D adenoviruses, which share 54.3 % to 55.1 % identity to TMAdV, with human adenoviruses of other species slightly less similar (51.1 % — 54.6 %).
Furthermore, severe infections from human adenoviruses are more commonly associated with older age, immunosuppression, and chronic underlying conditions such as kidney failure [4], [41].
Thus, the results of our serological survey appear unlikely to be due to nonspecific cross-reactivity from prior exposure to known human adenoviruses.
Although sequencing of PCR amplicons for human adenoviruses is not performed routinely in diagnostic virology, TMAdV would presumably have been detected previously in large - scale studies of hexon sequencing of Ad field isolates if it were circulating in the community [46], [47].
Incomplete splicing and deficient accumulation of the fiber messenger RNA in monkey cells infected by human adenovirus type 2
In fact, in the DNA polymerase gene, TMAdV shared a pairwise identity with PAdV - A of 67.2 %, comparable to its pairwise identities with the other human adenoviruses, 59 % — 71.7 % (Figs. 4 and S1).
Some serotypes, such as human adenovirus type 14 (HAdV - 14), have been associated with severe and potentially fatal outbreaks of pneumonia in residential facilities and military bases [4].
Humans are infected by common serotypes of human adenovirus such as AdHu5 and a significant percentage has neutralizing antibodies to this serotypes, which impair the efficacy of AdHu5 based vaccines.
But the new test found another seven, including a respiratory virus called human adenovirus B type 3A, which usually is harmless but can cause severe infections in some patients.
For their studies, Greber and his team with PhD students I - Hsuan Wang, Vardan Andriasyan and senior research scientist Dr. Maarit Suomalainen used cell cultures and human adenoviruses causing respiratory disease and conjunctivitis, herpes viruses and vaccinia virus, the latter in collaboration with Dr. Jason Mercer and his PhD student Samuel Kilcher from the ETH Zurich.
The work skirts a problem that has cropped up in experimental vaccines made from a similar human adenovirus — they don't work if you've already been exposed to the natural virus.
Despite their popularity — several HIV vaccines are in development using human adenoviruses — the approach has a significant drawback.
Finally, the available sequence data in GenBank is heavily biased towards human adenoviruses, and much less is known about the potential diversity of the simian adenoviruses.
We also sought to determine whether PCR assays commonly used to detect human adenoviruses in clinical or public health settings could detect TMAdV.
Human adenoviruses do not usually replicate in monkey cells in the absence of helper viruses [11], and do not productively infect rodents (and vice versa)[12].
Interestingly, pleurisy has been specifically reported in association with certain human adenovirus infections [44].
Synthesis of human adenovirus early RNA species is similar in productive and abortive infections of monkey and human cells
Normal translation of human adenovirus mRNA in cell - free lysates prepared from abortively as well as productively infected monkey cells
Microinjection of mRNA enhances translational efficiency of human adenovirus fiber message in monkey cells
Increased permissivity of monkey cells to human adenovirus multiplication is affected by culturing conditions and correlates with both synthesis of virion fiber protein and altered splicing of its mRNA
Then they inoculated mice with this vaccine, and, for comparison, another made from human adenovirus.
Pooled rabbit sera containing antibodies to human adenovirus serotypes 1 through 35, representing species A — E, were unable to neutralize TMAdV (data not shown).
Altered mRNA splicing in monkey cells abortively infected with human adenovirus may be responsible for inefficient synthesis of the virion fiber polypeptide
These viruses do not circulate in the human population and fail to carry neutralizing B cell epitopes that cross-react with the common serotypes of human adenoviruses.
There are innumerable different viruses, but the human adenovirus 5, which normally causes the symptoms of a typical cold, has substantial advantages: Its genome can be replaced completely by an artificial one which contains only «useful» genes.
But in mice that had been exposed to human adenovirus, only the chimp virus - based vaccine worked, the researchers report in the March issue of the Journal of Virology.
Atkinson says he and fellow researchers have found a human adenovirus that, when injected into chickens, mice, and monkeys, makes them fat.
To assess cross-neutralization of TMAdV by known human adenoviruses, 7 pools of in - house reference sera at the VRDL (rabbit hyperimmune sera) and collectively containing antibodies to human adenovirus serotypes 1 through 35 were available for testing.
The human adenoviruses in the Mastadenovirus genus, comprised of all mammalian adenoviruses, are classified into 7 species A-G, and at least 51 different serotypes (and 5 proposed types, HAdV - 52 to HAdV - 56) have been described to date [1], [2].
Abbreviations: HAdV, human adenovirus; SAdV, simian adenovirus; PAdV, porcine adenovirus; FAdV, fowl adenovirus.
Adenovirus PCR was performed on a TMAdV - positive clinical sample, a TMAdV culture, and a human adenovirus B culture (as a positive control) using an additional 5 pairs of primers, according to previously published protocols [26], [27], [28] Three of the 5 primer pairs, designed to detect human respiratory adenoviruses B, C, and E, failed to amplify TMAdV [27].
Interestingly, the 4 viral probes were derived from 2 different Adenoviridae genera (SAdV - 23, simian adenovirus 23, PAdV - A, porcine adenovirus A, and HAdV - 5, human adenovirus 5, in the Mastadenovirus genus; FAdV - D, fowl adenovirus D, in the Aviadenovirus genus), suggesting the presence of a divergent adenovirus that was not a member of any previously known species.
Abbreviations: HAdV, human adenovirus; SAdV, simian adenovirus; MAdV, mouse adenovirus, FrAdV, frog adenovirus; TAdV, turkey adenovirus; SnAdV, snake adenovirus; DAdV, duck adenovirus; OAdV, ovine adenovirus; BAdV, bovine adenovirus; PAdV, porcine adenovirus; TSAdV, tree shrew adenovirus; CAdV, canine adenovirus.
Abbreviations: FAdV, fowl adenovirus; SAdV, simian adenovirus; PAdV, porcine adenovirus; HAdV, human adenovirus, TMAdV, titi monkey adenovirus.
Posttranscriptional block to synthesis of a human adenovirus capsid protein in abortively infected monkey cells
Genetic evidence for separate functional domains on the human adenovirus specified, 72 kd, DNA binding protein
Characterization of the translational defect to fiber synthesis in monkey cells abortively infected with human adenovirus: Role of ancillary leaders
For instance, the human adenovirus - 36 (Ad - 36)-- a cause of respiratory infections and pinkeye — may also be a contributing factor to obesity, as it's been found to transform adult stem cells into fat cells that are capable of storing additional fat.
Human adenoviruses have been shown to last several months, with some studies even indicating they can last years.
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