Sentences with phrase «human adenovirus serotype»
To assess cross-neutralization of TMAdV by known human adenoviruses, 7 pools of in - house reference sera at the VRDL (rabbit hyperimmune sera) and collectively containing antibodies to human adenovirus serotypes 1 through 35 were available for testing.
http://journals.plos.org/
Pooled rabbit sera containing antibodies to human adenovirus serotypes 1 through 35, representing species A — E, were unable to neutralize TMAdV (data not shown).
Not exact matches
Some serotypes, such as human adenovirus type 14 (HAdV - 14), have been associated with severe and potentially fatal outbreaks of pneumonia in residential facilities and military bases [4].
Such antibodies are expected to reduce the efficacy of vaccines based on common human serotypes of adenovirus in a human target population.
These viruses do not circulate in the human population and fail to carry neutralizing B cell epitopes that cross-react with the common serotypes of human adenoviruses.
Humans are infected by common serotypes of human adenovirus such as AdHu5 and a significant percentage has neutralizing antibodies to this serotypes, which impair the efficacy of AdHu5 based vaccines.
Improving the oncolytic potency of agents has been hampered by the inability to study host - vector interactions in immune - competent systems, since human serotype adenoviruses do not productively replicate in animal tissues.