Sentences with phrase «human adenovirus such»
Humans are infected by common serotypes of human adenovirus such as AdHu5 and a significant percentage has neutralizing antibodies to this serotypes, which impair the efficacy of AdHu5 based vaccines.
https://wistar.org/ Not exact matches
Furthermore, severe infections from human adenoviruses are more commonly associated with older age, immunosuppression, and chronic underlying conditions such as kidney failure [4], [41].
Some serotypes, such as human adenovirus type 14 (HAdV - 14), have been associated with severe and potentially fatal outbreaks of pneumonia in residential facilities and military bases [4].
The facility routinely produces human and primate Adenovirus (Ad) and MVA vectors and its capability will soon expand to include other viral vector backbones, such as adeno - associated virus (AAV).
Such antibodies are expected to reduce the efficacy of vaccines based on common human serotypes of adenovirus in a human target population.