Sentences with phrase «human amyloid»
The phrase "human amyloid" refers to a substance called amyloid that can accumulate in the body, specifically in the brain, nerves, or other organs of humans. This accumulation can lead to certain diseases, such as Alzheimer's disease or systemic amyloidosis, which can cause problems with memory, thinking, and overall body functions. Amyloid is a type of protein that clumps together abnormally, and it is important to understand it to find ways to prevent or treat these diseases. Full definition
Specifically, rodents genetically modified to express human amyloid precursor protein (hAPP), which can lead to the debilitating plaques that form in the brains of Alzheimer's patients, seem to struggle to find the hidden platform relative to their healthy peers.
sciencemag.org
We compared transgenic mice that express human amyloid precursor protein (hAPP) and patients with mild cognitive impairment due to Alzheimer's disease (MCI - AD) to evaluate the sensitivity of performance measures in detecting deficits.
Increasing EphB2 levels in neurons of mice engineered to produce high levels of human amyloid proteins in the brain prevented their neurotransmission deficits, memory problems and behavioral abnormalities.
His laboratory and their collaborators have also identified human amyloid fibrils in semen that enhance the ability of HIV to infect new cells — a discovery that one day could help stem the global spread of this deadly pathogen.
His lab and its collaborators have also identified human amyloid fibrils in semen that enhance the ability of HIV to infect new cells — a discovery that one day could help reduce new instances of infection.
Most striking, he says, are results from mice engineered to make human amyloid ß.
All the mice died within 96 hours, but those with human amyloid lost less weight, had fewer bacteria in their brains, and lived up to roughly 30 hours longer than the control mice, the team reports today in Science Translational Medicine.
Frederick plans to continue using this NMR technique to study other yeast proteins, as well as human amyloid proteins.
The APP / PS1 transgenic mouse overexpresses mutated forms of the genes for human amyloid precursor protein (APPsw) and presenilin 1 (m146L) and is used to study amyloid deposition.
C. elegans expressing a modified form of human amyloid - β survived three or four more days following infection in the gut with Candida albicans, compared to wild - type worms that did not express the peptide.
Abstract: There exist several dozen lines of transgenic mice that express human amyloid - β protein precursor (AβPP) with Alzheimer's disease (AD)- linked mutations.
Human amyloid precursor protein (hAPP) transgenic mice from line J20, which carry mutations that cause early - onset AD (7), show major deficits in this assay (8).
Young mice that expressed high levels of human amyloid - β (but did not have pathological plaques) infected in the brain with Salmonella typhimurium were more likely to survive the infection compared to wild - type mice that did not express the peptide, Tanzi, Moir, and their colleagues found.
Overexpression of human amyloid - β protein precursor (AβPP) within the gut was assessed by qPCR and IHC; fecal microbiome analysis was conducted by 16SrRNA quantitation of selected phyla and species.
There exist several dozen lines of transgenic mice that express human amyloid - β protein precursor (AβPP) with Alzheimer's disease (AD)- linked mutations.