Sentences with phrase «human and mouse»

While promising, this research has been conducted only in human and mouse cells growing in the laboratory thus far.

Approximately half of the gene sequences of human and mouse genomes comes from so - called mobile elements — genes that jump around the genome.

The next year, it was used to edit the genomes of human and mouse cells, followed by frogs, monkeys and such crop plants as rice and wheat.

Key genetic differences between humans and mice make research rodents less than perfect patients.

To determine whether or not increased DNA gain or loss likely had an evolutionary impact we compared human and mouse gene expression divergence.

Humans and mice share many common genetic features and by examining the physiology, anatomy and metabolism of a mouse, scientists can gain a valuable insight into how humans function.

But mammals (including humans and mice) seem to have missed out on this important skill.

It was carried out on humans and mice and revealed altered intestinal bacteria and compromised glucose metabolism after relatively short trial periods.

While this is an attractive idea, an analysis of regulatory element evolution shows that lineage - specific regulatory innovation for development occurred prior to human and mouse divergence [78].

Then they compared the results with the genetically modified mice, as well with healthy humans and mice.

For example, he says, because humans and mice have different metabolic rates, lower doses may have similar beneficial effects in humans.

These differences, in turn, have been associated with increased risks of asthma, allergies, obesity, and immune deficiencies, in human and mouse studies.

However, there's a lot more genetic variation between humans and mice than there is amongst humans.

Humans and mice share about 97 percent of their genes.

(A — H) Learning curves for humans and mice in visible - target training (A and E) and hidden - target learning (B — D and F — H).

Mali and Yang got a single cluster of CRISPR molecules to edit multiple genes in human and mouse cells in one fell swoop, a breakthrough published in early 2013.

To make this discovery, the researchers stimulated isolated neutrophils from humans and mice with nicotine and could measure a dose - dependent release of inflammatory molecules.

Genetic studies in humans and mice with idiopathic epilepsy have revealed a number of causative genes for specific forms of epilepsy 31.

«Scientists analyze genetic makeup of human and mouse embryos in amazing detail.»

Newcomb and her colleagues looked at human and mouse cells to further study the trend in gender differences that they had observed.

Scientists publishing in Nature Communications report that they have developed a mini working replica of the female reproductive tract using human and mouse tissue.

In this study, published in Nature, researchers studied human and mouse models of ovarian cancer cells.

In a separate study, published in the March issue of the Journal of the American College of Cardiology (JACC) researchers from Penn Medicine, Harvard Medical School, Washington University in St. Louis, and nine other institutions, who also studied humans and mice, reported on a similar set of findings.

A team of postdoctoral and research scientists at the Wellcome Sanger Institute and MRC Cancer Unit has made data sets of human and mouse immune and stromal cells openly accessible on a preview site that provides initial access to data for the Human Cell Atlas initiative, before these have been published.

Furthermore, the findings illustrate the fundamental importance of HYAL2 and hyaluronan turnover for normal human and mouse development.

These are not genes but must have an important role because evolution has left them virtually unchanged in both humans and mice since our evolutionary paths parted about 75 million years ago.

We also generated human and mouse cells having a similar structural alteration using the CRISPR - Cas9 genome editing system, and confirmed that these cells actually showed an elevated expression of PD - L1 protein and were able to escape the immune attack.»

The result was a highly selective drug they named SBI - 0206965, which successfully killed a number of cancer cell types, including human and mouse lung cancer cells and human brain cancer cells, some of which were previously shown to be particularly reliant on cellular recycling.

Using cultured human and mouse endothelial cells, as well as a live mouse model, the researchers studied ammonia's effect on HO - 1.

Our data in humans and mice show that adipocyte size is a strong predictor of the percentage of macrophages in adipose tissue (Figure 3e).

The RNAs of enhancers are expressed before the genes they regulate during human and mouse cell differentiation.

We found that for genes in human and mouse DNA gain and loss hotspots and developmental process genes in mouse DNA loss hotspots (identified using GO terms) there was no significant association with conserved or divergent expression patterns (S8 Table).

However, it is important to realise that the majority of DNA losses occurred early after human and mouse divergence, and at this early time - point hg19 and mm10 DNA loss hotspots show a positive genomic association (Fig 8).

A 2014 study found that the compounds in amaranth were effective in blocking inflammation in both humans and mice by preventing the activation of a pathway that triggers inflammation (25).

Scientists poring over the 3 - billion - letter - long genomes of humans and mice made a host of new discoveries in 2005.

Within that stretch of DNA, the researchers found a gene known as ALX1, which has previously been identified in humans and mice as being associated with the formation of facial features.

While the basic cellular organization of the cortex in humans and mice looks the same, Rakic states, «the connections are different, the functionality is different.»

Researchers then tested human and mouse beta cells modified to express genetic variants of tribbles, and found that insulin secretion was blunted in both.

Researchers at Weill Cornell Medical College recently identified a gene abnormality that is associated with anxiety - related behaviors; it makes humans and mice hypervigilant to cues that signal danger.

Of those people who are morbidly obese, less than 1 percent harbor DNA mutations that disrupt the function of the leptin gene — a low rate of incidence that is not surprising, as leptin - deficient humans and mice are both in fertile, so these mutations do not pass readily to subsequent generations.

The scientists then exposed human and mouse airways to various bitter compounds to gauge the effects.

We have discovered that human and mice transcriptome contains both preserved and divergent elements.

Anatomical examination of human and mouse eyes was used to determine the effect of the laser on the sensitive light - detecting retina.

«Both in humans and mice there is a correlation between altered gut microbiota composition and inflammaging, but the link between the two remains to be proven in humans» concludes Fransen.

They found evidence of Del - 1 in the same areas as osteoclast activity, then followed up by generating human and mouse osteoclasts in vitro and found Del - 1 mRNA and protein expressed at high levels.

The experiment is reminiscent of studies that aim to rejuvenate the elderly humans and mice with blood transfusions from the young.