Sentences with phrase «human and mouse beta»

Not exact matches

Beta - amyloid protein is found in the brains of mice and humans.

In experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta - catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiply.

A chemical produced in the pancreas that prevented and even reversed Type 1 diabetes in mice had the same effect on human beta cells transplanted into mice, new research has found.

In marked contrast to the widely held notion that the insulin - producing pancreatic beta cell loses function with wear and tear, the researchers now show that mouse and human beta cells are fully functional at advanced age.

In addition, harmine treatment tripled the number of beta cells and led to better control of blood sugar in three groups of mice engineered to mimic human diabetes.

«By identifying the signals that instruct mouse progenitor cells to become cells that make tubes and later insulin - producing beta cells, we can transfer this knowledge to human stem cells to more robustly make beta cells, says Professor and Head of Department Henrik Semb from the Novo Nordisk Foundation Center for Stem Cell Biology at the Faculty of Health and Medical Sciences.

UBC Psychiatry Professor Dr. Weihong Song and Neurology Professor Yan - Jiang Wang at Third Military Medical University in Chongqing attached normal mice, which don't naturally develop Alzheimer's disease, to mice modified to carry a mutant human gene that produces high levels of a protein called amyloid - beta.

Investigators found that autophagy plays a role in clearing IAPP from pancreatic beta cells using three experimental models: pancreatic beta cells, isolated pancreatic islets from mice that express the human form of IAPP, and human islets.

Humans and mice share these chemical processes, so the researchers believe beta - endorphin may cause addiction in people.

Using human pancreatic samples and mouse models, the HSPH researchers — with colleagues from Harvard Medical School, the Broad Institute of Harvard and MIT, and the Université Libre de Bruxelles — sought to tease apart the mechanisms of beta cell failure in T1D.

The work highlights a previously unrecognized molecular pathway that contributes to the malfunction of insulin - producing pancreatic beta cells in T1D in human patients and in mice, and shows that a chemical intervention can help beta cells function properly and survive.

Indeed, when the researchers engineered connective tissue cells from mouse and human skin to produce PRDM16 and C / EBP - beta, they became fully functional brown fat.

«We found that insulin signaling can initiate the binding of this transcription factor with PLK - 1 and CENP - A, in both mouse and human beta cells,» Kulkarni says.

TGF - beta 1 plays an important role in the mechanism of CD4 + CD25 + regulatory T cell activity in both humans and mice.

Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors.

Next, moving from human tumors to a mouse model, they unraveled how activated beta - catenin prevents inflammation and blocks T cell penetration.

These reagents, prepared against human light chain - related fibrils, recognize an epitope common to the beta - pleated structure of AL and other types of amyloid proteins and can effect rapid amyloidolysis when administered to mice injected with human AL amyloid extracts.

This diversity of age among beta cells may be responsible at least in part for the striking heterogeneity that has been observed in both mice and humans.

Chong Wee Liew, Ph.D., lead author and a postdoctoral researcher in the Kulkarni lab, first examined the expression of the tribbles protein in pancreatic islets (which house beta cells and other hormone - producing cells) in both humans and mice.

He found that expression was elevated only in beta cells both in humans with type 2 diabetes and in mice that model the disease.

«Increased amyloid beta production is not seen in mouse neurons and could potentially explain some of the discrepancies between mice and humans regarding drug efficacy.

The markers highlighted the striking diversity of beta cell aging, and functional decline, both within and between islets in both mouse and human pancreases.

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