Sentences with phrase «human and mouse development»

Furthermore, the findings illustrate the fundamental importance of HYAL2 and hyaluronan turnover for normal human and mouse development.

Not exact matches

«We don't know if the observed reversibility of the disease symptoms as observed in the mouse,» he says, «exists in humans who have a much longer period of pre - and post-natal brain development than mice — months and years in humans, weeks in mice.»

PDX models are created by implanting cancerous tissue from a human primary tumor directly into immunodeficient mouse or rat models, enabling acceleration of oncology research or drug discovery and development programs.

Yet, in mouse embryos the researchers found that the human enhancer was active earlier in development and more active in general than the chimpanzee enhancer.

Duke scientists have shown that it's possible to pick out key changes in the genetic code between chimpanzees and humans and then visualize their respective contributions to early brain development by using mouse embryos.

Prof. Marine and his team generated a refined mouse model that faithfully reproduces the early stages of melanoma development in humans.

Many universities and pharmaceutical companies are engaged in research and development using genetically modified mice that have certain genes manipulated to reproduce human diseases.

«Epigenetic changes promote development of fatty liver in mouse and human.»

Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.

A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins.

The group has already started tweaking human iPS cells using the same genes that Saitou pinpointed as being important in mouse germ - cell development, but both Saitou and Hayashi know that human signalling networks are different from those in mice.

In humans and mice, the gene is associated with height, face development and other traits.

Early in embryonic development, both mouse and human placentas rely on the same set of ancient cell - growth genes.

But Husseini Manji, head of neuroscience research and development at Janssen Pharmaceutical Companies in Titusville, New Jersey, cautions against assuming that results in mice will bear out in humans.

Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.

«We identified that the peculiar look of these naked lizards is due to the disruption of the ectodysplasin - A (EDA), a gene whose mutations in humans and mice are known to generate substantial abnormalities in the development of teeth, glands, nails and hairs», says Michel Milinkovitch.

Hebrok found that when the Brg1 gene is knocked out in mice that are predisposed to PanIN development and subsequent PDA, lesions form that are similar to human IPMN.

The researchers found that PAI - 039 inhibited the migration of cultured human coronary artery smooth muscle cells, and prevented the development of blockages in arteries and bypass grafts in mice.

In his current position at The Jackson Laboratory, he has overall responsibility for the ongoing operational development of the PDX resource, which generates, banks, and distributes patient - derived xenograft (PDX) mouse models of human cancers.

«This association is important for lung development in mouse embryos, and at least for one of these long non-coding RNAs, important for human lung function.»

Green fluorescent protein labeling allowed them to see the early development pattern and show that lncND, which ordinarily is not present in mice — lncND is present only in some primates including humans — had a functional effect on development.

«With this development, we are now able to culture both mouse and human organoids, providing a very powerful tool in our fight against pancreatic cancer,» explains Tuveson.

The researchers used tools of epigenomic analysis to trace the specific epigenetic switches controlling each of thousands of genes in both mouse and human retinal cells as the cells progressed through development.

This factor is the first lung molecular marker during mouse and human development and is essential for lungs to mature properly in an embryo.

Our side by side analysis uncovers the dynamics of epigenetic programming occurring in germ cell development at single base resolution in human and mouse cells.»

The mice were then placed on a calorie - restricted diet, which usually precedes the development of anorexia in adolescent humans and may act as a trigger for eating disorders.

Though these findings have been obtained in mice, the scientists hypothesize that disrupted coordination between the development of the microglia and that of the brain contributes to an increased risk of such neurodevelopmental disorders as autism and schizophrenia in human beings.

Further testing found these mice had lower - than - expected growth hormone and insulin - like growth factor (IGF1) levels in the blood, potentially explaining the small stature and delayed development seen in human patients.

UCLA scientists, in collaboration with teams in China, have used the powerful technology of single - cell RNA sequencing to track the genetic development of a human and a mouse embryo at an unprecedented level of accuracy.

The new study is based on the development of mouse models manifesting the disease that causes megalencephaly, spasticity and ataxia in humans.

His team have begun recolonising the primate scaffolds with human cells that line blood vessels, the first step towards human - scale biolimb development, and have started experiments using human myoblasts in rats instead of the mice ones.

«Deviant alternative splicing, or mutations in the products of alternative splicing, have been tied to cancer, autism and serious development disorders, both in mice and in humans.

«Mouse and human kidney development compared: Findings may lead to advances in the study and treatment of kidney disease.»

To find out why, they examined genes in both mice and humans that turned on during peak brain development and spotted a DNA snippet, ARHGAP11B, that was active only in humans.

A second study, by a different research group, tracked human and mouse embryo development from fertilized egg to about six days later, just before the embryo implants in the uterine wall.

What we do know is that in mice (and so, presumably, in humans) FOXP2 is active in the brain during embryonic development.

The team found lower levels of TRNP1 in areas that were destined to form folds, and higher levels in areas that would not have developed them, suggesting that the protein produced by the gene inhibits more complex brain development in humans as well as in mice.

In 2012, scientists got their first hint that a gene called TRNP1 might influence brain development in both mice and humans.

«Assuming that we can equate developmental stages in mice and humans,» Snyder reflects, «these findings might be relevant to brain development and the genesis of anxiety in people too.»

The role of POU6F2 in corneal development and thickness in mice, however, points to the gene as a possible risk factor for glaucoma in humans that deserves further investigation.

The discovery may help explain why humans evolved more elaborate brains than mice, and it could suggest ways to treat disorders such as autism and epilepsy that arise from abnormal neural development.

Preclinical studies in mice and human cells suggested that the removal of SnCs significantly reduced the development of post-traumatic OA and related pain and created a prochondrogenic environment for new cartilage to grow and repair joints.

In a recent review, researchers from the French Institute of Health and Medical Research (INSERM), Atomic Energy Commission (CEA) and University of Paris - Diderot compared the effects of six potential EDs on the function of rat, mouse and human fetal testis at comparable stages of their development.

Investigating mouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imaMouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse models phenotyping imaging.

Using mouse models that replicate the complexity of human hepatocellular carcinoma genetics, he is working on unravelling the mechanisms of regeneration and cancer development in the liver.

It's such a subtle defect that these animals, called Aspm knockout mice, provide limited insight into human cortical development, says Walsh, who leads the Allen Discovery Center at Boston Children's Hospital and Harvard Medical School.

While this is an attractive idea, an analysis of regulatory element evolution shows that lineage - specific regulatory innovation for development occurred prior to human and mouse divergence [78].

The 19 NIH institutes, centers and offices contributing to the Knockout Mouse Project are: the NIH Office of Strategic Coordination / Common Fund; NCRR; the National Eye Institute; NHGRI; the National Institute of Allergy and Infectious Diseases; the National Heart, Lung and Blood Institute; the National Institute on Aging; the National Institute of Alcohol Abuse and Alcoholism; the National Institute of Arthritis and Musculoskeletal and Skin Diseases; the Eunice Kennedy Shriver National Institute of Child Health and Human Development; NIDCD; the National Institute of Dental and Craniofacial Research; the National Institute of Environmental Health Sciences; the National Institute of General Medical Sciences; the National Institute of Mental Health; the National Institute of Neurological Disorders and Stroke; the National Institute of Diabetes and Digestive and Kidney Diseases; the National Cancer Institute; and the Office of AIDS Research.

Genetically engineered mice now act as robust engines for the generation of diverse repertoires of affinity - matured, fully - human variable regions with intrinsic drug - like properties necessary for successful development including high potency, specificity, manufacturability, solubility and low risk of immunogenicity.

«Our decision to procure these knockout mouse lines and data and make them available to the research community will yield tremendous benefits, both in the short and long terms,» said NIH Director Elias A. Zerhouni, M.D. «This trans - NIH initiative will place important mouse models into the hands of researchers, speeding advances in the understanding of human disease and the development of new therapies.