Sentences with phrase «human and mouse divergence»

However, it is important to realise that the majority of DNA losses occurred early after human and mouse divergence, and at this early time - point hg19 and mm10 DNA loss hotspots show a positive genomic association (Fig 8).

While this is an attractive idea, an analysis of regulatory element evolution shows that lineage - specific regulatory innovation for development occurred prior to human and mouse divergence [78].

Collectively, these results demonstrate that it is possible to identify locations for the majority of DNA gain and loss events since human and mouse divergence.

Not exact matches

To better understand the spatio - temporal dynamics of DNA gain and loss, we dated individual DNA gain or loss events using a series of ingroup species that each mark specific divergence events between either human or mouse (Methods).

Gene expression divergence levels were obtained from [71] and were measured in terms of the number of commonly co-expressed genes between human and mouse one to one orthologs.

After the initial divergence event between human and mouse, both genomes underwent their highest rates of DNA loss which continued to slow down throughout their evolution (Fig 8a and 8b).

This is likely true for two reasons; 1) there would not have been much time for a large number of chromosomal rearrangements to occur between these early ancestral human and mouse genomes, 2) and that since divergence with the boreoeutherian ancestor the human genome has undergone only a small number of chromosomal rearrangements meaning that many human telomeric regions are ancestral [58, 73].

To determine whether or not increased DNA gain or loss likely had an evolutionary impact we compared human and mouse gene expression divergence.