Sentences with phrase «human and mouse gene»

To determine whether or not increased DNA gain or loss likely had an evolutionary impact we compared human and mouse gene expression divergence.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

In fact, though many human and mouse genes appear to be similar, they may have taken on slightly different roles, or be active at different times during the life of a person or a mouse.

Researchers have produced vast libraries of short segments of ribonucleic acid (RNA) that can be used to turn off individual human and mouse genes to study their function.The libraries will be made...

Not exact matches

Infant formula continues to evolve and there are patents already for implanting genes for making human milk in mice.

As part of the study, researchers found that mice engineered to develop symptoms of human inflammatory disease, and which also lacked the ATG16L1 gene, developed gut damage.

Until now, roughly 150 imprinted genes have been found in mice and about half that number in humans.

Both mouse and human males typically die early from the mutation in Mecp2, because their Y chromosome does not supply a normal copy of the gene.

Researchers at Weill Cornell Medical College recently identified a gene abnormality that is associated with anxiety - related behaviors; it makes humans and mice hypervigilant to cues that signal danger.

Humans and mice share about 97 percent of their genes.

These four genes and their proteins constitute the heart of the biological clock in flies, and with some modifications they appear to form a mechanism governing circadian rhythms throughout the animal kingdom, from fish to frogs, mice to humans.

In a test of this theory, researchers have demonstrated that mice harboring a human SCN1A gene mutation that results in Dravet Syndrome (DS), a severe and intractable genetic epilepsy, have electrical disturbances in the heart that culminate in ventricular fibrillation and sudden cardiac death.

In today's issue of Cell, a team reports that it has found in mice and humans a close relative of a fruit fly clock gene — the first evidence that some of these genes may have been conserved over the course of evolution.

This consortium selected 44 separate sections of the genome that included regions of high to low gene density and high to low similarity between mouse and human.

The researchers have compared various processes involved in gene expression, such as gene transcription and chromatin modification, and have repeated this in different tissues and cell types from both humans and mice.

Like the per gene, the new genes — dubbed RIGUI in humans and m - rigui in mice — are turned on and off in a daily cycle and may work with other genes to generate the oscillating mechanism that runs the internal clock.

In addition, the researchers have quantified the preservation level of this gene expression between humans and mice.

Molecular geneticist Cheng Chi Lee, developmental biologist Gregor Eichele, and their co-workers at the Baylor College of Medicine in Houston have isolated a gene in mice and humans that shares 44 % of the amino acid sequence of the period (per) gene of the fruit fly Drosophila melanogaster.

The UT Southwestern group had previously used CRISPR - Cas9, the original gene - editing system, to correct the Duchenne defect in a mouse model of the disease and in human cells.

The IGF1 protein is crucial for the growth of mammals, including mice and humans, so Ostrander's group and other collaborators began collecting DNA from additional breeds to see if they also shared the same gene variant.

Many universities and pharmaceutical companies are engaged in research and development using genetically modified mice that have certain genes manipulated to reproduce human diseases.

When we took the mouse version of this gene — the same gene we find in the human — and put it in the fly and tweaked it, we induced fly eye tissue.

The human (and all the other) genome projects were predicated on the reasonable assumption that spelling out the full sequence of genes would reveal the source of that diversity of form and attributes that so readily distinguish worm from fly, mouse, chimp and human.

Using the new gene - editing enzyme CRISPR - Cpf1, researchers at UT Southwestern Medical Center have successfully corrected Duchenne muscular dystrophy in human cells and mice in the lab.

The loss of a single gene in mice can affect social behavior and impair their brains» ability to filter out distractions — both characteristics of several neurological diseases in humans.

Already, researchers have used CRISPR / Cas9 to edit genes in human cells grown in lab dishes, monkeys (SN: 3/8/14, p. 7), dogs (SN: 11/28/15, p. 16), mice and pigs (SN: 11/14/15, p. 6), yeast, fruit flies, the worm Caenorhabditis elegans, zebrafish, tobacco and rice.

In the current work, they used a new variation of the gene - editing system to repair the defect in both a mouse model and in human cells.

To see if they would suffice to make H5N1 infection less severe, Webby and his co-workers injected mice with DNA for the neuraminidase gene from human H1N1, one of three flu subtypes covered by this winter's flu shot.

Mice without the leptin gene, called ob / ob, overeat, weigh in at three to four times normal, and develop symptoms similar to the obesity - related diabetes seen in humans.

Compared with earlier methods to tweak the genomes of bacteria, plants, laboratory mice and human cells, the Crispr - Cas9 gene - editing method is fast, precise and cheap, an order of magnitude better than the others.

All animals use the same enzyme to create the same methylation mark as a signal for gene repression, and her colleagues who study epigenetics in mice and humans are excited about the new findings, Strome said.

A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins.

By comparing our genetic make - up to the genomes of mice, chimps and a menagerie of other species (rats, chickens, dogs, pufferfish, the microscopic worm Caenorhabditis elegans, the fruit fly Drosophila melanogaster and many bacteria), scientists have learned a great deal about how genes evolve over time, and gained insights into human diseases.

These are not genes but must have an important role because evolution has left them virtually unchanged in both humans and mice since our evolutionary paths parted about 75 million years ago.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

The group has already started tweaking human iPS cells using the same genes that Saitou pinpointed as being important in mouse germ - cell development, but both Saitou and Hayashi know that human signalling networks are different from those in mice.

In humans and mice, the gene is associated with height, face development and other traits.

The problem is that in animals, such as mice and humans, there are many histone genes and they are scattered throughout the genome.

One gene, which codes for a powerful growth - stimulating hormone in mice and humans, is expressed only by paternally derived genes.

Before Katlyn showed up at NIH, the doctors there were already well prepared: They had inserted healthy human ADA genes into a modified mouse retrovirus — a type of virus that can enter human cells and transfer new genetic material right into the DNA strands in their nuclei.

We currently produce DNA microarrays representing the yeast, mouse, and human genomes (the yeast microarray has over 6000 yeast genes, the mouse microarray has over 15,000 mouse genes, and the two human microarrays have 1700 genes and over 19,000 genes).

Two recent studies — one in mice and another in humans — provide new evidence that a mind - numbingly complex array of genes influence body weight.

Although that marker, called IL21, had not previously been associated with autoimmune diseases, the gene that produces it sits right in the stretch of DNA known to make these mice vulnerable to diabetes, suggesting that IL21 might make a drug target, says Sarvetnick.Furthermore, by giving the animals a shot of dead bacteria — similar to an immunization in humans — when they were newborns, Sarvetnick and her colleagues prevented a surfeit of CD4 + and CD8 + cells.

Now, a new study in mice shows how a gene, called FOXP2, implicated in a language disorder may have changed between humans and chimps to make learning to speak possible — or at least a little easier.

Early in embryonic development, both mouse and human placentas rely on the same set of ancient cell - growth genes.

Buxbaum and his coworkers point out that FOXP2 is also expressed in the brains of songbirds such as finches and canaries, and further studies of the gene in mice might provide a better understanding of its role in human communication.

Fittingly, most of these genes reside in ampliconic regions of the X and appear to have been acquired independently during the 80 million years since mouse and human diverged from a common ancestor.

By studying how these genes cause defects in fly and mouse models, we can improve our insights into the mechanisms related to human disease,» said corresponding author and Dr. Hugo J. Bellen, professor of neuroscience and molecular and human genetics at Baylor College of Medicine and an investigator at the Howard Hughes Medical Institute.

Although the gene / cell therapy strategy was highly successful in laboratory mice, the authors stressed that additional research and testing are needed before the therapy could be tested in humans.

Such genes play an important role in mate selection — not just in bats, but also in mice and possibly even humans.