Sentences with phrase «human and mouse genomes»

While there are only a few hundred ultraconserved sites in the human and mouse genomes, there are also approximately 100,000 other, less well - conserved enhancers.

267/4: 30 Extremely high resolution 3D maps of human and mouse genomes across lineages and during differentiation reveal principles of chromatin looping.

About half of the sequence of the human and mouse genomes is derived from these mobile elements.

Human and mouse genomes are thought to have approximately 70,000 genes (Antequera and Bird, 1993; Collins, 1995).

If the genome projects verify the underlying octoploid nature of the human and mouse genomes, then the basic vertebrate gene number may be similar to that of the fly and worm, about 12,000 to 14,000 genes.

This is likely true for two reasons; 1) there would not have been much time for a large number of chromosomal rearrangements to occur between these early ancestral human and mouse genomes, 2) and that since divergence with the boreoeutherian ancestor the human genome has undergone only a small number of chromosomal rearrangements meaning that many human telomeric regions are ancestral [58, 73].

To better characterise the molecular drivers and evolutionary impacts of DNA gain and loss, we calculated lineage - specific gain and loss rates across the human and mouse genomes.

The FANTOM project has drawn up a list of all the promoters in human and mouse genomes.

For example, while the genomes of two humans may only differ by 0.1 %, two strains of the same bacteria can vary by to 30 % — similar to the variation between human and mice genomes.

Not exact matches

«Our study shows that epigenetic drift, which is characterized by gains and losses in DNA methylation in the genome over time, occurs more rapidly in mice than in monkeys and more rapidly in monkeys than in humans,» explains Jean - Pierre Issa, MD, Director of the Fels Institute for Cancer Research at LKSOM, and senior investigator on the new study.

The mouse, dog and human genomes are of high quality whereas the three others are at different stages of analysis completion.»

The performance of our workflow was assessed on vertebrate genome assemblies of various qualities (platypus, pig, horse, dog, mouse and human).

This consortium selected 44 separate sections of the genome that included regions of high to low gene density and high to low similarity between mouse and human.

The scientists have detailed the functional parts of the mouse genome and have compared them with those in humans.

The human (and all the other) genome projects were predicated on the reasonable assumption that spelling out the full sequence of genes would reveal the source of that diversity of form and attributes that so readily distinguish worm from fly, mouse, chimp and human.

Scientists poring over the 3 - billion - letter - long genomes of humans and mice made a host of new discoveries in 2005.

Compared with earlier methods to tweak the genomes of bacteria, plants, laboratory mice and human cells, the Crispr - Cas9 gene - editing method is fast, precise and cheap, an order of magnitude better than the others.

By comparing our genetic make - up to the genomes of mice, chimps and a menagerie of other species (rats, chickens, dogs, pufferfish, the microscopic worm Caenorhabditis elegans, the fruit fly Drosophila melanogaster and many bacteria), scientists have learned a great deal about how genes evolve over time, and gained insights into human diseases.

Bejerano and his colleagues originally noticed ultraconserved elements when they compared the human genome to those of mice, rats and chickens, and found 481 stretches of DNA that were incredibly similar across the species.

The problem is that in animals, such as mice and humans, there are many histone genes and they are scattered throughout the genome.

Studies comparing the mouse and human sequences that accompany the mouse genome in the journal Nature suggest it provides plenty of new leads in biology and disease.

We currently produce DNA microarrays representing the yeast, mouse, and human genomes (the yeast microarray has over 6000 yeast genes, the mouse microarray has over 15,000 mouse genes, and the two human microarrays have 1700 genes and over 19,000 genes).

We can use clues from similarities with the mouse and human genomes.

• Piero Anversa at New York Medical College in Valhalla, New York, and Donald Orlic at the National Human Genome Research Institute in Bethesda, Maryland, used mouse bone marrow to repair damaged mouse hearts.

But the primary sequences of the human, mouse, and rat genomes are also tools from which we can derive the protein sequence for each gene.

Once the vector is ready, the Baylor team wanted to be able to guide it to a certain part of the genome every time, so they turned to a technique called ΦC31, which was known to work in human and mouse cells.

The mouse genome is sometimes described as the human genome chopped into 150 pieces and put back in a different order along the mouse's 21 chromosomes.

The genome shares about 60 % of its genes with the other invertebrates completely sequenced, such as the nematode and fruit fly, whereas about 5 % match sequences found only — up to now, at least — in the human, mouse, and puffer fish genomes.

Pavel Pevzner and Glenn Tesler compared the just - sequenced mouse genome with its human counterpart and analyzed where rearrangements, a common type of genetic mutation, occur.

Soon, the mouse — which from a genetic point of view is nearly human — will join this ship: its genome is sought in another race between the publicly funded mouse genome sequencing project and Celera.

The study, conducted in both human and mouse cells, shows that cancer genomes lose copies of repetitive sequences known as ribosomal DNA.

The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole - genome shotgun assembly of the mouse genome.

Building on years of mouse and gene regulation studies, they have developed a resource that can help scientists better understand how similarities and differences between mice and humans are written in their genomes.

Mice and humans share approximately 70 percent of the same protein - coding gene sequences, which is just 1.5 percent of these genomes.

Their findings — reported by the mouse ENCODE Consortium online Nov. 19, 2014 (and in print Nov. 20) in four papers in Nature and in several other publications — examine the genetic and biochemical programs involved in regulating mouse and human genomes.

A significant amount of junk DNA proves to be conserved in the genomes of mice and humans.

But now that three vertebrate genomes have been sequenced — human, mouse, and pufferfish — geneticists are re-thinking their appraisal.

Based on the six other published mammalian genomes (human, chimpanzee, mouse, rat, dog and cow), the sequencers estimated that the feline genome contained some 20,000 genes.

It has launched projects such as a major effort to develop knock - out mice (ScienceNOW, 7 September 2006) and The Cancer Genome Atlas (Science, 16 December 2005, p. 1751), which, with the cancer institute, is sequencing mutations in human cancers.

The genome of the Western lowland gorilla has now been sequenced and assembled at a high level of quality beginning to approach that of the mouse and human genome.

-- Mice and humans both have about 30,000 genes - and share 99 % of them - but the mouse genome is shorter than that of humans (2.5 billion letters compared with 2.9 billion)---- About 1,200 new genes have been discovered in the human because of mouse - human genome comparisons.

Raymond White, a human genetics researcher at UCSF's Ernest Gallo Clinic and Research Center in Emeryville, said the points of similarity between mouse and human genomes were vitally important — they represent bits of genetic material that have survived, intact, over 75 million years of evolution.

Mouse - to - human genome comparisons have shown that, in addition to common genes, the two species share a surprising amount of DNA code that controls when and how these genes turn on or off.

In these experiments, Berger and colleagues show that somatic PREX2 mutations identified through whole - genome sequencing of human melanoma can contribute to enhanced lethality of tumor xenografts in nude mice (Figure 3B, S6B, and S6C; Berger et al., 2012).

In a study published online in Genome Research, researchers devised a strategy for genome - wide annotation of primary miRNA transcripts, providing extensive new annotations in human and mouse, and shedding light on mechanisms of regulation of microRNA gene expreGenome Research, researchers devised a strategy for genome - wide annotation of primary miRNA transcripts, providing extensive new annotations in human and mouse, and shedding light on mechanisms of regulation of microRNA gene expregenome - wide annotation of primary miRNA transcripts, providing extensive new annotations in human and mouse, and shedding light on mechanisms of regulation of microRNA gene expression.

In a series of publications today in the British scientific journal Nature, international teams of researchers published a nearly complete sequence of the genetic instructions of «Black 6,» the most common breed of laboratory mouse, and matched its traits with the recently decoded human genome.

The catalog of mouse and human genes yielded by these genome projects will cut years of time from otherwise painstaking laboratory research.

Sample and genome - wide, DPI identified 3.5 million peaks in the human genome and 2.1 million peaks in the mouse genome.

Caribou's market - leading CRISPR - Cas9 gene editing technology can accurately target and cut DNA to produce precise and controllable changes to the genome, which can be applied by JAX to create mouse models that better recapitulate human diseases enabling researchers to find better treatments faster.

After the initial divergence event between human and mouse, both genomes underwent their highest rates of DNA loss which continued to slow down throughout their evolution (Fig 8a and 8b).