Sentences with phrase «human and mouse osteoclasts»

They found evidence of Del - 1 in the same areas as osteoclast activity, then followed up by generating human and mouse osteoclasts in vitro and found Del - 1 mRNA and protein expressed at high levels.

Not exact matches

Further experimentation in vitro with human osteoclasts and in vivo in mice identified a portion of the Del - 1 protein that was particularly important for containing osteoclast activity, though additional parts of the molecule were needed to have the most potent inhibition of inflammation and bone loss.

To investigate the underlying mechanisms, we undertook (1) bioinformatic, functional genomic annotation and human osteoblast expression studies; (2) gene - function prediction; (3) skeletal phenotyping of 120 knockout mice with deletions of genes adjacent to lead independent SNPs; and (4) analysis of gene expression in mouse osteoblasts, osteocytes and osteoclasts.