Sentences with phrase «human aneuploidies»

In gametes (eggs and sperm), chromosome mis - segregation can lead to human aneuploidies like trisomy 21 that causes Down syndrome.

Although Hunt stresses that no data clearly link BPA to human aneuploidy, she thinks the question deserves study because the compound is so widely used.

Not exact matches

Given the rapid succession of generations in yeast, we can use it as a model organism — and study the mechanisms of aneuploidy in much greater detail to find out whether we can derive from it new approaches for diagnosing and treating human diseases.»

In humans, aneuploidy is the leading cause of birth defects, miscarriage, and mental retardation.

Aneuploidy is known to be deleterious and underlies several common human diseases, including cancer and genetic disorders such as trisomy 21 in Down's syndrome.

Aneuploidy is well known to be deleterious in humans, causing genetic disorders like Down's syndrome or trisomy 21.

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells.

Aneuploidy (an abnormal number of chromosomes) is the most common genetic alteration in human tumors and a major cause for birth defects (Figure 4).

Errors in chromosome segregation are a major cause for birth defects and embryonic lethality in humans, and the most common genetic alteration in human tumors is aberrant chromosome numbers, called aneuploidy.

Errors in chromosome segregation can cause birth defects and embryonic lethality in humans and cause aneuploidy, the most common genetic alteration in tumors.

This study enabled us to propose mitotic defects, aneuploidy and consequent cell death as a new etiology of Human Primary Recessive Microcephaly (MCPH).

Moreover, many human tumors have highly abnormal numbers of chromosomes (that is, they are aneuploid), with initial chromosomal loss participating in the early steps of the transformation cascade in inherited cancers caused by heterozygous mutation in tumor suppressor genes and the more widespread aneuploidy characteristic of advance tumors thought to drive acquisition of malignant growth properties.??

Over the past few years, studies in both humans and model organisms have provided insight into factors that are key components of the generation of aneuploidy.

148/5: 15 Complex mitotic - origin aneuploidy in human embryos: Genetic risk factors and fertility consequences.

Today academic institutions and teaching hospitals across the country receive federal or private grants to support groundbreaking research using human fetal tissue on a wide range of conditions including diabetes, Parkinson's disease, Alzheimer's disease, spinal cord injuries, hemophilia, leukemia, sickle cell anemia, cortical blindness, fetal aneuploidy, ALS, and others.