Sentences with phrase «human antibodies»

The newly identified site can be attacked by human antibodies in a way that neutralizes the infectivity of a wide variety of HIV strains.

Marks et al. «By - Passing Immunization: Building High Affinity Human Antibodies by Chain Shuffling», Bio / Technology, 10: 779 - 783, 1992.

They extract human albumen, human antibodies for medical purposes, and AAT enjoys this extraction.

Human Antibodies From V - Gene Libraries Displayed on Phage», Journal of Molecular Biology, 222: 581 - 597, 1991.

As an example, Harrison is trying to use EM to investigate interactions of human antibodies with the influenza hemagglutinin glycoprotein.

Genetic engineering of human antibodies; host defense mechanisms against microbial infection.

Using standard enzyme - linked immunosorbent assays (ELISA) and peripheral blood mononuclear cell (PBMC) assays, researchers discovered that unlike previously described human antibodies to lipids, WR321 did not react with any of 17 other lipids it was tested against, including cholesterol, glycolipids, and other phospholipids such as cardiolipin and phosphatidylserine, but it bound specifically only to two phosphoinositides.

Researchers have discovered that a subset of human antibodies have catalytic activity against a particular antigen, breaking it down into smaller and less harmful fragments instead of trapping it for removal or destruction by other immune cells.

Around the same time that transgenic mice began to be used to produce human antibodies, scientists also started employing a genomic technology called phage display to build massive libraries of human antibody genes that could be screened quickly.»

Rapid Discovery of High - Affinity, Human Antibodies Against 17 Immuno - Oncology Targets Using Molecular Genomic Screening Methods Keystone Symposia conference Whistler, British Columbia Feb. 26, 2018

Trianni has the leading chimeric human mouse for generation of fully human antibodies.

Not only are human antibodies less likely to provoke an unwanted immune reaction, but in some cases they could also be given subcutaneously, once every four to six weeks, rather than through weekly intravenous treatments, according to Anthony Coyle, vice president and chief scientific officer of the Centers for Therapeutic Innovation at Pfizer.

Similar experiments were performed demonstrating that the purified human antibodies also protected immunosuppressed hamsters against lethal disease caused by Sin Nombre virus.

This research involved the use of specially bred «transchromosomal» cows that have been engineered to produce fully human antibodies.

The purified human antibodies had «potent neutralizing activity against both hantaviruses,» according to the paper's first author, Jay W. Hooper, Ph.D, of the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID).

Our results show that immunization can induce potent and broadly neutralizing antibodies in llamas with features similar to human antibodies and provide a framework to analyze the effectiveness of immunization protocols.

«New method to generate human antibodies.»

So far, Robl has more than two dozen transgenic cloned calves making human antibodies.

The next step, he says, is to knock out the cows» own antibody genes, so they will produce only human antibodies.

In August they reported the birth of four cloned calves that are genetically equipped to make human antibodies.

This molecule, a type of sugar, has become chemically glued to a location on the virus's surface near where human antibodies — immune system watchdogs — attach to mark the virus as a dangerous invader.

In the current study, Vanderbilt researchers led by graduate student Andrew Flyak, the paper's first author, used a high - efficiency method they developed to quickly isolate and generate large quantities of monoclonal human antibodies from the blood of survivors of a 2007 outbreak in Uganda who were infected by the Bundibugyo ebolavirus.

«This work points the way to using fully human antibodies as the next generation of antibody therapeutics,» Crowe said.

Malamud's microfluidic machine uses four microscopic channels to simultaneously scan a sample: The first looks for human antibodies to the infectious agent, the second for an antigen on the surface of the pathogen, and the third and fourth amplify viral RNA or bacterial DNA.

«The quality of these naturally occurring human antibodies as biological drugs to treat the virus infection is remarkable, and we are doubly encouraged because they recognize multiple species of Ebola,» said immunologist James Crowe, Director of the Vanderbilt Vaccine Center.

The wing was particularly important for researchers to map since it appears to be one of only two known sites where protective human antibodies can bind.

The company now has an array of fully human antibodies in its pipeline created with its proprietary VelocImmune mouse, which has been engineered to express human antibody genes while still mounting a robust immune response by making antibodies with fully human variable regions and mouse constant regions.

In the lab, they coupled the H1N1 virus with human antibodies — immune system soldiers that fight off foreign invaders.

Researchers at Vanderbilt University Medical Center have isolated human antibodies against a type of bird flu that has killed more than 200 people in China since 2012 and which may pose a worldwide pandemic threat.

«First human antibodies to work against all ebolaviruses.»

«Since it's impossible to predict which of these agents will cause the next epidemic, it would be ideal to develop a single therapy that could treat or prevent infection caused by any known ebolavirus,» says study co-leader Zachary A. Bornholdt, Ph.D., director of antibody discovery at Mapp Biopharmaceutical, Inc. «Our discovery and characterization of broadly neutralizing human antibodies is an important step toward that goal,» adds study co-leader, Kartik Chandran, Ph.D., professor of microbiology & immunology at Albert Einstein College of Medicine.

Scientists at Dana - Farber Cancer Institute have identified natural human antibodies against the virus that causes Middle East Respiratory Syndrome (MERS), a step toward developing treatments for the newly emerging and often - fatal disease..

Marasco and colleagues found the MERS antibodies using a «library» of some 27 billion human antibodies they have created and maintain in a freezer at Dana - Farber; it is one of the largest such libraries in the world.

A company called Hematech is already breeding genetically engineered cattle (derived from cloned stem cells) that produce human antibodies to fight bacterial infections, and the animals» welfare is not compromised in any way.

Unlike other human antibodies under investigation that recognize both Zika and the closely related dengue virus, the antibodies used in this study exclusively target Zika, demonstrating a high specificity that could be important in avoiding potential side effects — such as enhanced dengue infection in regions where both viruses are endemic.

In people infected with HIV who develop broadly neutralizing antibodies, this antibody region — called HCDR3 — has about 30 amino acids, about twice as long as what is usual for human antibodies.

The alternative PCSK9 inhibitors evolocumab and alirocumab, which have already been approved for use, are fully human antibodies and do not have this adverse effect.»

Sharon used molecular biology methods to express and purify the virus peptide and NMR spectroscopy to analyze its structure as it is bound to neutralizing human antibodies.

«Natural Human Antibodies to Dietary Lectins.»

In the case of ones immunte system... the wider the sources of human antibodies... the better.

Both sharks and humans make antibodies to invading antigens — with one key difference: Human antibodies are shaped a bit like a serving fork, with one prong being the so - called heavy chain, and the other the light chain.

That was followed by the takeover of Kairos Therapeutics, a Vancouver startup re-engineering human antibodies to fight cancer.

Fibriansah et al. report that a human antibody (2D22) specific for DENV serotype 2, when given therapeutically, can protect mice from a lethal form of this virus.

A human antibody specific for dengue virus locks viral envelope proteins into a conformation that prohibits viral entry.

A radio - labeled human antibody binds to the viral gp41 protein expressed on the surface of the HIV - infected human lymphocyte and the cell is killed by alpha radiation delivered by the antibody.

To ensure best possible binding of the antibody to cancer cells in dogs, the human antibody had to be trimmed to «dog» in the laboratory.

A single dose of a human antibody called ZIKV - 117 can protect mice from death after Zika infection — and shield mouse fetuses from the virus's damaging effects, researchers report November 7 in Nature.

A single dose of a human antibody called ZIKV - 117 can shield mouse fetuses from the virus's damaging effects, researchers report online November 7 in Nature.

The first step was to insert an artificial chromosome containing the cumbersome human antibody gene into the nucleus of a cow cell.

The researchers took a portion of the human antibody protein IgG and fused it to the cat protein responsible for cat allergy.