Sentences with phrase «human antibody gene»

The first step was to insert an artificial chromosome containing the cumbersome human antibody gene into the nucleus of a cow cell.

The company now has an array of fully human antibodies in its pipeline created with its proprietary VelocImmune mouse, which has been engineered to express human antibody genes while still mounting a robust immune response by making antibodies with fully human variable regions and mouse constant regions.

Around the same time that transgenic mice began to be used to produce human antibodies, scientists also started employing a genomic technology called phage display to build massive libraries of human antibody genes that could be screened quickly.»

Not exact matches

Nils Lonberg, a Harvard - trained molecular biologist who worked at Medarex, had figured out not only how to engineer a mouse with human immune genes but also how to make antibodies from these genes that were fully human as well.

Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models.

«We also confirmed that human patients with a missing or malfunctioning DNASE1L3 gene had an abundance of circulating DNA and developed antibodies to it, and that such antibodies were also present in most forms of lupus,» says Reizis.

The researchers also pinpointed the human genes that are the likely source of the immune cells that produce the two antibodies.

Researchers report in Nature today that they have perfected a way to manufacture monoclonal antibodies capable of destroying diseases such the avian flu, which have the ability to swap genes with human flu varieties and jump from birds to people.

The next step, he says, is to knock out the cows» own antibody genes, so they will produce only human antibodies.

Furthermore, there is very limited similarity to the human germ line V gene VH1 - 2 * 02 precursor of the VRC01 - like broadly neutralizing antibodies isolated from multiple patients.

The 12th release of the Human Protein Atlas (HPA) covers 16,621 genes (approximately 83 % of the human protein - coding genes) and includes protein expression profiles based on 21,984 antiboHuman Protein Atlas (HPA) covers 16,621 genes (approximately 83 % of the human protein - coding genes) and includes protein expression profiles based on 21,984 antibohuman protein - coding genes) and includes protein expression profiles based on 21,984 antibodies.

This version covers 15,156 genes (approximately 75 % of human protein - coding genes) and includes protein expression profiles based on 18,707 antibodies.

The experiments often require drastic steps (such as knocking out genes, killing cells with antibodies, sewing animals together) that are impossible in human beings.

The breakthrough arrived in the form of genetically engineered mice that, thanks to inserted human genes, made antibodies that were fully human.

This is only done for the antibodies corresponding to genes where the mouse and human genes are orthologous.

Human Antibodies From V - Gene Libraries Displayed on Phage», Journal of Molecular Biology, 222: 581 - 597, 1991.

Further, we have a keen interest in developing innovative methods for antibody modeling and design (Willis, J.; et al.; «Human germline antibody gene segments encode polyspecific antibodies»; PLoS Comput Biol; 2013; 9; 100304).

The injection helps block pain receptors responsible for migraines — calcitonin gene - related peptides (CGRPs)-- using antibodies cloned from humans.