Not exact matches
The new inoculation series
requires an injection of
human or horse immunoglobulin, which is in short supply in developing countries, but the University of Massachusetts Medical School in Boston is currently testing a strategy in India that uses monoclonal
antibodies that could one day be easily manufactured in China.
An
antibody engineered to prevent excessive bleeding in patients with severe hemophilia A may be safe and effective, and
require fewer injections than existing options, according to a first - in -
human study of the treatment published online today in Blood, the Journal of the American Society of Hematology (ASH).
The experiments often
require drastic steps (such as knocking out genes, killing cells with
antibodies, sewing animals together) that are impossible in
human beings.
• Addressing the
human - specific nature of
antibodies is possible using Organ - Chips that recreate the complexity of
human biology, since novel
antibody targets are not expressed in animals and therefore
require alternatives to current preclinical experimental methods.
The partnership is designed to use Organ - Chips that reflect the complex biology
required to model the effects of therapeutic
antibodies in
humans, overcoming the limitations of current preclinical experimental methods.