But, he says, because the researchers used
the human bitter taste receptors, it's likely that the same thing happens when a diet drink hits the human tongue.
The team also found that probenecid, a known inhibitor of
human bitter taste receptors, also worked on both cat taste receptors, preventing stimulation when in the presence of PTC, aloin and denatonium.
Not exact matches
Like its
human counterpart, the cat
bitter taste receptor Tas2r43 was activated by
bitter compounds aloin (found in the aloe plant) and denatonium (used to deter children and pets from consuming chemicals such as antifreeze) but responded differently to the compounds.
Now, scientists from the Perelman School of Medicine at the University of Pennsylvania reveal that the release of AMPs is partially controlled by
bitter taste receptors in the upper airway on a cell previously identified in animals and only recently in
humans known as solitary chemosensory cells (SCCs).
The teams at AFB International and Integral Molecular studied the behavior of two different cat
bitter taste receptors in cell - based experiments, investigating their responsiveness to
bitter compounds, and comparing these to the
human versions of these
receptors.
TAS2R38 is a
bitter taste receptor in
humans of which some people have «supertaster» variants that give them an extreme sensitivity to
bitter compounds, explaining some people's strong aversions to broccoli and brussels sprouts.
Though it doesn't fit into the five established
tastes the tongue's
receptors can identify — sweet, sour, salty,
bitter and savory (umami)--
humans can
taste it, and describe it as slightly
bitter and sour.