Not exact matches
So Daniel Anderson at the Massachusetts Institute of Technology exposed
human bone marrow stem cells to biodegradable nanoparticles carrying the
human gene for vascular endothelial growth factor (VEGF),
which attracts blood vessels to injury sites.
Then, to boost the number of cells,
which is another hurdle in tissue engineering, the researchers mixed the chondrocytes with
human mesenchymal stem cells from
bone marrow.
Dr. Zubair, medical and scientific director of the Cell Therapy Laboratory at Mayo Clinic in Florida, says the experiment will be the first one Mayo Clinic has conducted in space and the first to use these
human stem cells,
which are found in
bone marrow.
Tufts University biomedical engineers recently published the first report of a promising new way to induce
human mesenchymal stem cells (or hMSCs,
which are derived from
bone marrow) to differentiate into neuron - like cells: treating them with exosomes.
The researchers used «humanized mice,»
which have had their immune systems replaced with
human immune system cells, thymus tissue and
bone marrow.
She ultimately chose to study leukemia patients» immune responses to
bone marrow transplants, an area conducive to translational research in part because the work involves treating patients with
human cells,
which can be prepared at academic health centers.
Patients receive one of two types of stem cell - based transplants: autologous, in
which a patient donates and receives back his / her own stem cells; or allogeneic, in
which bone marrow - derived stem cells come from a related or unrelated donor whose
human leukocyte antigens (HLA) are genetically matched with those of a patient.
If successful, this may lead to therapies for
humans in
which a patient's stem cells will be reverted into iPSCs, then genetically repaired and transplanted back into the
bone marrow of the same patient.
Using primary murine
bone marrow derived macrophages or
human monocyte derived dendritic cells, infected with live or attenuated Chlamydia trachomatis we report that the live organism activates both canonical and non-canonical inflammasomes, but only canonical inflammasomes controlled IL - 1β processing
which preceded pyroptosis.