The 1 - in - a-billion CAQK peptide (dark blue) also targets injured sites
in human brain samples, showing its potential for precise drug delivery.
Her research activity is focused on the three - dimensional reconstruction of intact neuronal networks, with cellular resolution, of the whole mouse brain using light sheet microscopy and
human brain samples with two - photon fluorescence microscopy.
Thanks to these predictions, the scientists at the CRG together with the team of Fina Martí at IDIBAPS, were able to screen and validate the candidates in vitro (via cell culture), in vivo (with mice), and ex vivo (
using human brain samples from dead patients).
Using
postmortem human brain samples, the researchers found that variations in the number of copies of the C4 gene that people had, and the length of their gene, could predict how active the gene was in the brain.
Analysis of
more human brain samples, including smaller brain nuclei, is thus desirable in order to generate a more detailed map of protein distribution in the brain.
The team discovered that the levels of various lipids found
in human brain samples, especially from the neocortex, stood out.
The researchers followed up with an analysis of mouse and
human brain samples.
Analyses of amplified bacterial 16 s rRNA sequences disclosed that Proteobacteria was the principal bacterial phylum in
all human brain samples with similar bacterial rRNA quantities in HIV and ODC groups despite increased host neuroimmune responses in the HIV group.