Sentences with phrase «human breast cancer»

In one study, pomegranate extract was found to inhibit the growth of human breast cancer cells by inducing cell death.

Should collaborations like these prove to be important also in human breast cancer, disrupting key interactions may be a novel treatment strategy for the disease.

This is an environmental estrogen that activates the increased production of human breast cancer cells.

The idea that a virus can cause human breast cancer has been around for nearly fifty years.

It also inhibits the growth of cultured human breast cancer cells, leading to cell death.

The operation of the nanoparticles was demonstrated in the laboratory using human breast cancer cells.

Scientists have routinely used mice to replicate aspects of human breast cancer in an effort to find a cure to the most common type of cancer among women.

In a 2005 study, he described what happened when he took melatonin - depleted blood from premenopausal women who had been exposed to light at night and infused it through human breast cancer xenografts in nude rats.

Recent studies with human breast cancer cell lines have also shown that Shp2 mediates survival signals in cancer cells.

Immunohistochemistry of paraffin - embedded human breast cancer tissue slide using 66240 -1-Ig (beta Tubulin antibody at dilution of 1:400 (under 10x lens)

Pre-clinical studies have shown it to be effective in eliminating a number of different kinds of cancers cells, including cancer stem cells from human breast cancer patient biopsies.

As a next step, Guha, Avadhani and colleagues plan to extend this study to in vivo mouse models and will also investigate these mechanisms in tumor samples from human breast cancer patients.

Unlike previous MRI studies of tumors in mice, the researchers were able to detect very small naturally occurring cancers, which were excellent models for human breast cancer; the tumors the mice developed were «realistic models of the most frequently detected human cancers,» the authors wrote.

An Improved Syngeneic Orthotopic Murine Model of Human Breast Cancer Progression Breast Cancer Research and Treatment 2014 Oct; 147 (3): 501 - 12.

The findings, now published in PLOS Genetics, reveal how mice can actually mimic human breast cancer tissue and its genes, even more so than previously thought, as well as other cancers including lung, oral and esophagus.

Immunohistochemistry of paraffin - embedded human breast cancer slide using 60004 -1-Ig (GAPDH Antibody) at dilution of 1:50

To investigate, Joan Massagué and his colleagues at the Memorial Sloan - Kettering Cancer Center in New York city injected human breast cancer cells into the arteries of mice.

Primary human breast cancer samples were obtained from the Dana - Farber Cancer Institute with patients» consent and institutional review board approval.

In this study, the researchers tested the effects of Olaparib on the tumors formed by human breast cancer cells injected into mice.

Bloch's colleagues at the National Institute of Environmental Health Sciences tested the oils in gene expression studies on lab - grown human breast cancer cells and found that they could mimic estrogens, the primary female sex hormones, and inhibit androgens, the primary male sex hormones.

The findings imply that radiation could be especially effective in treating human breast cancers caused by similar mutations.

«They also imply that MenaINV expression and TMEM score measure related aspects of a commonly used mechanism that human breast cancers use to metastasize.»

Hill co-authored one of the most startling studies in the field in July 2014, when he reported in the journal Cancer Research that the drug tamoxifen is rendered completely ineffective against human breast cancer in mice when they are exposed to dim light at night.

MicroRNA - 34a suppresses cell proliferation by targeting LMTK3 in human breast cancer mcf - 7 cell line.

Mass spectrometry ‐ based cellular thermal shift assay (MS ‐ CeTSA) analysis of CDK4 / 6 inhibitor palbociclib targets in MCF7 human breast cancer cells identifies protein complexes including the 20S proteasome.

Two metastatic human breast cancer cell lines (MDA - MB 231 and BCM2) were used to optimize the conditions of hypoxia and reoxygenation cycles.

CLA decreases human breast cancer cell growth [2].

«There are still many questions left to answer but we now know that oxygen poor environments, like those often found in advanced human breast cancers serve as nurseries for the birth of cancer stem cells,» says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine and a member of the Johns Hopkins Kimmel Cancer Center.

In many human breast cancers, Numb concentration is low and this is associated with a poor prognosis for the patients.

In this new study, described Feb. 21 in Cell Reports, Semenza and his colleagues conducted gene expression analysis of multiple human breast cancer cell lines grown in the laboratory after exposure to chemotherapy drugs, like carboplatin, which stops tumor growth by damaging cancer cell DNA.

When Menendez bathed human breast cancer cells with purified oleic acid, the cells cut production of a cancer - causing gene, HER2, by nearly 50 percent.

In the lab, the scientific team used an approach that combined functional RNAi analysis with gene expression analysis in breast cancer - derived cell lines and in human breast cancers replicated in mice.

«Just like human breast cancer, there are many subtypes that can be found in mice,» said Eran Andrechek, co-author and physiology professor whose work focuses on the genetic makeup of cancer.

Now, University of Pennsylvania researchers have revealed how a reduction in mitochondrial DNA content leads human breast cancer cells to take on aggressive, metastatic properties.

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

Though unproven and hotly debated, the theory remains intriguing because known cancer - causing genes such as BRCA - 1 explain only a percentage of human breast cancer cases, and because viruses do cause other forms of cancer in humans and animals.

A new paper published online in the journal Cancer Research, «CCR5 governs DNA damage and breast cancer stem cell expansion,» describes the research, which shows that the co-receptor for HIV is found on a small population of cells within human breast cancers.

«The morphology of these early murine mammary cancers on MRI is similar to the MR presentation of early human breast cancer.»

Using a well - established ER + / PR + human breast cancer model (T47D) implanted in immune - compromised mice, they tested their theory in four groups of mice.

[53] We have also demonstrated similar effects of GHRH antagonists on in vivo cytokine gene expression by HCC1806 and MX - 1 triple negative human breast cancer.

«It is believed that environmental and lifestyle factors, such as diet, play a critical role in increasing human breast cancer risk, and so we use animal models to reveal the biological mechanisms responsible for the increase in risk in women and their female progeny,» says Hilakivi - Clarke.

DNA nanorobots are the latest weapon against the scourge of cancer, as researchers were able to program them to kill human breast cancer tumors in mice.

The authors had previously profiled tumorigenic and non-tumorigenic human breast cancer populations and profiled their microRNA content.