Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor
samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of
human breast cancer.
Originated 1970s by Dr. Henry Lemon, who tested estrogen levels in 24 hour urine
samples and found that an EQ > 1 strongly correlated with a higher survival rate after
breast cancer.24 Further research conducted by Lemon, Heidel, et al., a meta - analysis of published fractional estrogen excretion collected from 2,846 healthy women worldwide aged 15 to 59 years, with a risk of
breast cancer varying five-fold, found that an EQ < 1 reflects increased rates of oxidation of estrone or estradiol to 4 - OH catechols (also referred to in the literature as the 3,4 - catechol estrogen quinones), which have been identified as the principal proximal
human mammary carcinogens after menarche, while an EQ > 1 reflects conversion to protective 2 - OH estrogen metabolites.2526