Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of
human breast cancer suppression and to advances in its diagnosis and therapy.
In tumors formed by
human breast cancer cells, DNA damage (brown staining) is increased by simultaneous Olaparib treatment and PGAM1
suppression (right) when compared to either Olaparib treatment (left) or PGAM1
suppression (center) alone.