Sentences with phrase «human breast cancers use»

«They also imply that MenaINV expression and TMEM score measure related aspects of a commonly used mechanism that human breast cancers use to metastasize.»

Not exact matches

Using the modified system, human melanoma and breast cancers as well as mouse melanoma cells were diagnosed with greater ease and efficiency.

Using this biosensor in highly invasive breast cancer cells taken from rodents and humans, the Einstein team discovered that when an individual invadopodium forms and is actively degrading the ECM, its Rac1 levels are low; on the other hand, elevated Rac1 levels coincide with the invadopodium's disappearance.

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of drug candidates against cancer stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.

Additional experiments using a combination of maraviroc and a drug that blocks the VEGF protein suggest that the treatment duo could be an effective way to prevent metastatic disease in human breast cancer patients, according to the researchers.

Eran Andrechek, a physiology professor in the College of Human Medicine at Michigan State University, has discovered that many of the various models used in breast cancer research can replicate several characteristics of the human disease, especially at the gene lHuman Medicine at Michigan State University, has discovered that many of the various models used in breast cancer research can replicate several characteristics of the human disease, especially at the gene lhuman disease, especially at the gene level.

In the lab, the scientific team used an approach that combined functional RNAi analysis with gene expression analysis in breast cancer - derived cell lines and in human breast cancers replicated in mice.

Using these multidimensional datasets for human breast cancer, PLK4 was identified as a candidate target among 10,000 other targets for the development of anticancer therapeutics.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

Human breast tumors transplanted into mice are excellent models of metastatic cancer and are providing insights into how to attack breast cancers that no longer respond to the drugs used to treat them, according to research from Washington University School of Medicine in St. Louis.

«If further studies validate that these processes are critical in human breast cancers,» Koshy notes, «the possibility exists that agents that favorably modify the biophysical properties of the extracellular matrix, or that target the receptors and signaling molecules associated with how cells sense this matrix, could be used as a new avenue for the prevention or treatment of breast cancers.»

A new study from the University of Illinois reports long - lasting cognitive impairments in mice when they are administered a chemotherapy regimen used to treat breast cancer in humans.

This study provides one of the first animal models to demonstrate the long - term cognitive deficits resulting from a chemotherapeutic treatment used in treating humans for breast cancer.

The analysis of doxorubicin resistance in human breast cancer cells using antibody microarrays.

Immunohistochemistry of paraffin - embedded human breast cancer slide using 60004 -1-Ig (GAPDH Antibody) at dilution of 1:50

Dr. Jos Jonkers» research group studies the genetic basis of human breast cancer, using advanced mouse models for p53 - induced breast cancer, BRCA1 - and BRCA2 - associated hereditary breast cancer, and E-cadherin mutated invasive lobular carcinoma.

«In particular, his approach can be thought of as a very advanced biological therapy for the treatment of breast cancer; one that uses viruses, which are better recognized to cause disease, to treat human breast cancers.»

The study used three cell types: human motor neurons derived from induced pluripotent stem cells, rat cortical cultures, and human breast cancer cells.

Using cutting - edge techniques enabled by next - generation sequencing, the authors generated complete methylome maps at single nucleotide resolution in a low - passage breast cancer cell line and normal breast tissue (primary human mammary epithelial cells).

Immunohistochemistry of paraffin - embedded human breast cancer tissue slide using 66240 -1-Ig (beta Tubulin antibody at dilution of 1:400 (under 10x lens)

A major focus of their current cancer research is using animal, cell - based, molecular, and biophysical approaches to investigate the role of HIF - 1 in vascular and lymphatic metastasis of human breast cancer.

Conditions for hypoxia / reoxygenation cycles were optimized using two human metastatic breast cancer cell lines (MDA - MB 231 and BCM2).

Immunohistochemistry of paraffin - embedded human breast cancer tissue slide using 10379 -1-AP (SNRPD3 Antibody) at dilution of 1:50 (under 10x lens)

Using RNA interference (RNAi), first author Richard Possemato targeted these genes in human breast cancer cells implanted in mice.

«It is believed that environmental and lifestyle factors, such as diet, play a critical role in increasing human breast cancer risk, and so we use animal models to reveal the biological mechanisms responsible for the increase in risk in women and their female progeny,» says Hilakivi - Clarke.

Then, using semi-quantitative real - time PCR, we found that the expression of miR - 142 was able to upregulate the expression of miR - 150 in human breast cancer MDA - MB - 231 cells (Figure 5C).

(21 - 22)(39) Three previous large scale human studies revealed increased breast cancer with progestin use.

Dr. Lakshmanaswamy used a mouse model which mimiced breast cancer in humans.

Excessive proliferation of human breast cancer cells is never good, so countries in Europe started banning and restricting the use of these chemicals.

Guidelines for the appropriate use of herbs in human preliminary research see promise in the use of dandelion as an anti-cancer agent for both breast and prostate cancer.

According to Lise Alschuler, author of the Definitive Guide To Cancer: An Integrative Approach to Prevention, Treatment, and Healing, studies on flax lignans demonstrate safety and efficacy in their use against breast cancer, «inhibiting the growth of human estrogen - dependent breast cancer cells in mice and strengthening the tumor - inhibitory effect of tamoxifen&rCancer: An Integrative Approach to Prevention, Treatment, and Healing, studies on flax lignans demonstrate safety and efficacy in their use against breast cancer, «inhibiting the growth of human estrogen - dependent breast cancer cells in mice and strengthening the tumor - inhibitory effect of tamoxifen&rcancer, «inhibiting the growth of human estrogen - dependent breast cancer cells in mice and strengthening the tumor - inhibitory effect of tamoxifen&rcancer cells in mice and strengthening the tumor - inhibitory effect of tamoxifen».

Tamoxifen, a product commonly used for human breast cancer, is ineffective and has the potential for serious side effects in dogs.

It has also been found that a drug called megesterol (Megace), which is used in human breast cancer as well as a birth control product; medroxyprogesterone acetate (Depo - Provera) will also cause this disease to go into remission.

In the 1990s, several reports linked DDT to human cancers [3] and [4] and the insecticide was found in breast milk; [5] however, WHO continued to promote DDT use.

The court's ruling overturned a lower court decision that voided a patent held by Myriad Genetics on BRCA1 and BRCA2, two human genes used in determining the risk that women face with breast and ovarian cancer.