These molecular subtypes have recently been confirmed in a comprehensive characterization of
human breast tumors at the genomic, epigenetic, transcriptomic, and proteomic levels (Cancer Genome Atlas Network, 2012).
Not exact matches
Oncologists William Hahn, Robert Weinberg, and colleagues
at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, mutated the gene for one part of the enzyme and inserted it into cultured
human cells from colon, ovary, and
breast tumors.
Now, in Stem Cells Translation Medicine, the group of Shu Wang
at the National University of Singapore describe the derivation of EPCs from
human iPSCs, their therapeutic modification, and their ability to inhibit
tumor growth in a mouse
breast cancer model [4].
Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in vitro and in vivo in numerous
human tumor cell lines and xenograft models (including
human breast, prostate, and lung carcinoma)
at clinically achievable concentrations.
And we confirmed that the growth of the
tumors formed by the
human BCSCs transfected with the anti-miR-142-expressing lentivirus was significantly slower than those of the control
tumors formed by the control lentivirus transfected BCSCs (Major points raised by the editors and the reviewers # 3) These data suggest that the regulation of APC and the Wnt signaling is
at least one of the important pathways targeted by miR - 142 in
human breast cancer cells and BCSCs.
You drip some water on a
human breast tumor, and nothing happens; it's still powering away
at 100 % growth rate.
Veterinary oncologists working with a program
at the University of Pennsylvania are treating mammary
tumors in shelter dogs with the hope of learning about the progression of
breast cancer in
humans.