Sentences with phrase «human cancer cell lines»

Using human cancer cell lines helps, but the crucial interplay between the cancers and their host environments is absent.

To validate their computer modeling predictions, researchers performed experiments in human cancer cell lines, mouse liver samples and primary human hepatocytes.

«We've seen this in six different types of human cancer cell lines in the lab,» Choudhury said.

In studies on rats and mice, 3BP was reported to reduce growth of tumors or even shrink them, and experiments on human cancer cell lines showed that combining another chemotherapeutic with 3BP increased its efficacy.

The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.

For this reason, the National Cancer Institute maintains a library of 60 authenticated human cancer cell lines for the purposes of research, called the NCI - 60.

McKay and Tsai searched human cancer cell lines and found a human version of nucleostemin.

To determine whether the reactivation of methylation - silenced genes by EGCG is a general phenomenon that also occurs in other cell lines, we studied the effects of EGCG treatment on the methylation status and mRNA levels of p16INK4a or RARβ in three other human cancer cell lines (Fig. 3C) ⇓.

Today, one of the main focuses in Dey's lab is working with human cancer cell lines to study oxygen - sensing metallo - enzymes.

Inhibition of growth, production of insulin - like growth factor - II (IGFII), and expression of IGF - II mRNA of human cancer cell lines by antagonistic analogs of growth hormone - releasing hormone in vitro.

The extract was found to have cytotoxicity against several human cancer cell lines, while promoting apoptosis and cell cycle arrest.

In studies using human cancer cell lines, a new, never - described compound known as BMH - 21 destroyed this critical communication pathway.

Azacytidine and Decitabine induce gene - specific and non-random DNA demethylation in human cancer cell lines

NCI's efforts to develop new laboratory models of human cancer includes vastly increasing the number of human cancer cell lines (grown as two - dimensional and three - dimensional cultures) and patient - derived tumor xenografts.

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

But the lab nimbly moves through an experimental menagerie that also includes plants, mice and human cancer cell lines.

Using CRISPR, I was able to knockout BRAF in a human cancer cell line in about 1 month, which I'd say is pretty amazing.

In another study, 11 human cancer cell lines (carcinomas and glioblastomas) were exposed to ascorbic acid in which 55 % of the cell lines were more susceptible (EC50 ≤ 20 mmol / L) and 45 % were more resistant (EC50 > 20 mmol / L) to incubation.

(Source) Another study examined the inhibitory effects of clove ethyl acetate extract on human cancer cell lines.