Sentences with phrase «human cancer genome»

He witnessed the same phenomenon that he had seen in the human cancer genome databases.

... The projects that are ongoing, like the Human Cancer Genome Project, [have] really opened up a lot of possibilities to understand the molecular basis of cancer.

Two other big initiatives fared better: a proteomics effort to identify proteins in blood and other biomarkers that might work as early warning signs of cancer, and the most recent: a human Cancer Genome Atlas.

Activity of the APOBEC enzymes has been linked to specific mutational processes in human cancer genomes.

Not exact matches

I realize that that may be opposing the will of God who made the human genome as dodgy as it is and therefore made cancer not just possible but almost inevitable.

«Our study shows that epigenetic drift, which is characterized by gains and losses in DNA methylation in the genome over time, occurs more rapidly in mice than in monkeys and more rapidly in monkeys than in humans,» explains Jean - Pierre Issa, MD, Director of the Fels Institute for Cancer Research at LKSOM, and senior investigator on the new study.

One - third of yeast genes have counterparts in the human genome, many of which are associated with diseases, such as cancer.

He directs The Cancer Genome Atlas (TCGA), an initiative of the U.S. National Cancer Institute (NCI) and the U.S. National Human Genome Research Institute.

An analysis of the HPV16 genome from 5,570 human cell and tissue samples revealed that the virus actually consists of thousands of unique genomes, such that infected women living in the same region often have different HPV16 sequences and variable risks to cancer.

«This model was trained on genetic data from human tumors in The Cancer Genome Atlas and was able to predict response to certain inhibitors that affect cancers with overactive Ras signaling in an encyclopedia of cancer cell lines,» GreeneCancer Genome Atlas and was able to predict response to certain inhibitors that affect cancers with overactive Ras signaling in an encyclopedia of cancer cell lines,» Greenecancer cell lines,» Greene said.

Although researchers do not yet know the biological significance of these discoveries, they say that fully cataloguing the genome may help them understand how genetic variations affect the risk of contracting diseases such as cancer as well as how humans grow from a single - celled embryo into an adult.

By starting from scratch, she wonders, «could we make the human genome cancer - resistant?

Readers will have at their fingertips key articles in the history of science from the late 19th through the early 21st centuries, including research about the human genome, breast and colon cancer genes, and the Bose - Einstein condensate in physics.

Mutations in mitochondrial DNA have been linked to development of the cancer, so Anita Kloss - Brandstätter of Innsbruck Medical University in Austria and colleagues compared the entire mitochondrial genome of cancerous and non-cancerous tissue from 30 men with prostate cancer (The American Journal of Human Genetics, DOI: 10.1016 / j.ajhg.2010.11.001).

In contrast, viruses that cause cancer, such as the human papillomavirus that is responsible for most cases of cervical cancer, disrupt a cell's genome, thereby triggering out - of - control growth.

«The elephant results revealed noncoding sequences in the human genome that we predict may control gene activity and reduce the formation of mutations and cancer.»

From a bat's wings to an elephant's cancer resistance, an interdisciplinary team of scientists at University of Utah Health are using animals» unique traits to pinpoint regions of the human genome that might affect health.

She quoted Nancy Edwards, a professor at Harvard Medical School (8): «If we have the audacity to believe that we can find cures for cancer and understand the human genome, why should it be hard to believe that we can fix the culture of our profession?»

He has chaired numerous NIH committees and served on the National Advisory Council for Human Genome Research and the NCI Mouce Models for Human Cancer Consortium.

Tamayo and team tested REVEALER using The Cancer Genome Atlas (TCGA), the National Institutes of Health's database of genomic information from more than 500 human tumors representing many cancer Cancer Genome Atlas (TCGA), the National Institutes of Health's database of genomic information from more than 500 human tumors representing many cancer cancer types.

The study, «VlincRNAs controlled by retroviral elements are a hallmark of pluripotency and cancer» found that novel non-coding parts of the human genome known as vlincRNAs (very long intergenic, non-coding RNAs) triggered by ancient viruses, participate in the biology of stem cells, and in the development of cancer.

Evidence of vegetarian diet permanently shaping human genome to change individual risk of cancer, heart disease.»

The research team from the National Human Genome Research Institute (NHGRI) and the National Cancer Institute (NCI), both parts of NIH, extended their recent genome sequencing study of skin bacteria, using DNA sequencing techniques optimized for identifying Genome Research Institute (NHGRI) and the National Cancer Institute (NCI), both parts of NIH, extended their recent genome sequencing study of skin bacteria, using DNA sequencing techniques optimized for identifying genome sequencing study of skin bacteria, using DNA sequencing techniques optimized for identifying fungi.

He said the accumulation of mutations in the human genome was the main driving force behind aging - related diseases and cancer development.

In previous studies, including recent genome sequencing of cancer patients, human SETD2 has been implicated in several cancer types, especially in renal cell carcinoma — the most common kind of kidney cancer.

This phenomenon could result in breakage in the human genome, and when a breakage impacts important genes, such as tumor suppressors, it could lead to cancer development.

«The parts of the human genome linked to complex diseases such as heart disease, cancer and neurological disorders can often be far away from the genes they regulate, so it can be dificult to figure out which gene is being affected and ultimately causing the disease.»

In addition, the researchers examined neuroligin - 3 data from The Cancer Genome Atlas, a large public database of human cancer genCancer Genome Atlas, a large public database of human cancer gencancer genetics.

«NGS technologies have vastly improved our understanding of the human genome and its variation in diseases such as cancer,» said Ken Chen, Ph.D., assistant professor of Bioinformatics and Computational Biology and co-author of the Nature Methods article.

«Previously, genome - wide screens were only possible in lower animals, such as flies, worms and yeast, where it is often difficult to assess the relevance to human disorders such as cancer.»

That paper, which acknowledges the contributions of the Lacks family, pieced together the complex, rearranged genome of the HeLa cells and identified an insertion of the human papilloma virus near an oncogene that may explain the aggressiveness of Lacks» cancer.

New results reported in this week's Science and at a genome meeting held last week at Cold Spring Harbor Laboratory on New York's Long Island suggest that our pedigreed canine companions may be a major help in finding the genetic keys to common human afflictions such as cancer, diabetes, and mental disorders.

Cancer researchers first suggested sequencing the human genome in the mid-1980s.

The study, conducted in both human and mouse cells, shows that cancer genomes lose copies of repetitive sequences known as ribosomal DNA.

The company's thermal cyclers were used by every major genome centre during the sequencing of the human genome and were most recently used by the BC Cancer Agency during the sequencing of the SARS virus.

Already researchers at the Cancer Genome Atlas project (a collaboration of the National Cancer Institute and the National Human Genome Research Institute) are sequencing mutations involved in more than 20 types of cCancer Genome Atlas project (a collaboration of the National Cancer Institute and the National Human Genome Research Institute) are sequencing mutations involved in more than 20 types of cCancer Institute and the National Human Genome Research Institute) are sequencing mutations involved in more than 20 types of cancercancer.

The results of this original study are highly relevant to other human diseases that dependent on genome instability, such as fungal infection or cancer, and open new venues for anti-leishmanial drug discovery using host - directed strategies that target the parasite's metabolic dependence on the host cell, thus preventing the adaptive evolution of drug resistant parasites.

Related sites Matthew Meyerson's home page More about cervical cancer and HPV from the National Cancer Institute The Human Genome Pcancer and HPV from the National Cancer Institute The Human Genome PCancer Institute The Human Genome Project

Peter and his team discovered sequences in the human genome that when converted into small double - stranded RNA molecules trigger what they believe to be an ancient kill switch in cells to prevent cancer.

It has launched projects such as a major effort to develop knock - out mice (ScienceNOW, 7 September 2006) and The Cancer Genome Atlas (Science, 16 December 2005, p. 1751), which, with the cancer institute, is sequencing mutations in human caCancer Genome Atlas (Science, 16 December 2005, p. 1751), which, with the cancer institute, is sequencing mutations in human cacancer institute, is sequencing mutations in human cancers.

Following a postdoctoral fellowship in the National Human Genome Research Institute at the National Institutes of Health (NIH), Dr. Wei stayed on at NIH, first as a biologist and currently as a staff scientist, in the Pediatric Oncology Branch of the National Cancer Institute.

«All of these [studies] are pretty important for cancer research,» says cancer geneticist Paul Meltzer of the National Human Genome Research Institute in Bethesda, Maryland.

Following his postdoctoral training at the INSERM U. 311 in Strasbourg, France and the Cancer Genetics Branch at the National Human Genome Research Institute in Bethesda, Maryland, Dr. Azorsa joined the Translational Genomics Research Institute (TGen) based in Phoenix, Arizona.

The human genome contains around 20,000 genes, by refining CRISPR - Cas9 technology and using it to screen the leukemia genome the team uncovered a catalogue of approximately 500 genes that are essential for cancer cell survival, including more than 200 genes for which drugs could be designed.

In a Philadelphia Inquirer op - ed, he wrote that such eternal life was in our reach because «Being able to decode the human genome allows us to develop detailed models of how major diseases, such as heart disease and cancer, progress, and gives us the tools to reprogram those processes away from disease.»

The study analyzed data from The Cancer Genome Atlas (TCGA), a research program supported by the National Cancer Institute and National Human Genome Research Institute within the National Institutes of Health that is looking at genomic changes in more than 20 different types of cCancer Genome Atlas (TCGA), a research program supported by the National Cancer Institute and National Human Genome Research Institute within the National Institutes of Health that is looking at genomic changes in more than 20 different types of cCancer Institute and National Human Genome Research Institute within the National Institutes of Health that is looking at genomic changes in more than 20 different types of cancercancer.

423 Number of genes in the human genome that have been implicated in cancer, according to the Sanger Institute's Cancer Gene Ccancer, according to the Sanger Institute's Cancer Gene CCancer Gene Census.

The researchers from the University of South Carolina College of Pharmacy and School of Medicine discovered this new subtype by analyzing data from 255 cervical cancer samples in The Cancer Genome Atlas, a large - scale federally funded project launched in 2005 by the National Cancer Institute and National Human Genome Research Instcancer samples in The Cancer Genome Atlas, a large - scale federally funded project launched in 2005 by the National Cancer Institute and National Human Genome Research InstCancer Genome Atlas, a large - scale federally funded project launched in 2005 by the National Cancer Institute and National Human Genome Research InstCancer Institute and National Human Genome Research Institute.

In 2012, as part of efforts to better understand the causes of melanoma, researchers at the Broad Institute, the Dana - Farber Cancer Institute and a number of other institutes reported the results of whole genome sequencing of 25 human metastatic melanomas (Berger et al., 2012).

The team selected possible leads from the intersection of more than 20,000 p53 binding sites in the human genome, 10 million inherited genetic variations genotyped in the 1000 Genomes Project, and 62,000 genetic variations associated with human cancers identified in genome - wide association studies (GWAS).