Sentences with phrase «human cardiovascular disease»

We apply modern technologies including next generation sequencing to help discover mechanisms and pathways relevant to human cardiovascular disease, such as atherosclerosis, atrial fibrillation, and HDL metabolism.

«The grant provides us an exciting opportunity to understand these mechanisms in human cardiovascular disease and to discover new immune - based targets for cardiovascular disease,» says Hedrick.

Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease.

We will continue to investigate how it guides blood vessel growth, with the ultimate aim of tapping on its potential as a target to address human cardiovascular diseases.»

Not exact matches

In March, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion to include a new indication for adults with established atherosclerotic cardiovascular disease (myocardial infarction, stroke or peripheral arterial disease) to reduce cardiovascular risk by lowering LDL - C levels.

Cocoa polyphenols are beneficial to human health with regards to cardiovascular and inflammatory diseases, metabolic disorders, and in the prevention of cancers.

Kuo, H.K and Fujise, K. Human papillomavirus and cardiovascular disease among U.S. women in the National Health and Nutrition Examination Survey 2003 and 2006.

Because the food we consume directly impacts our health, it is important to note that an infant who develops a «taste» for salty, sweet and fatty foods over fruits and vegetables will have a greater risk for diabetes, hypertension, cardiovascular disease and some cancers according to Mennella's and Beauchamp's Flavor Perception in Human Infants article.

- Why breastfeeding protects maternal health - Basic concepts of breast differentiation, lactogenesis, and lactation - Basic overview of the human stress response - Introduction to psychoneuroimmunology and the immunology of pregnancy and postpartum - Lactational stress resistance - Breastfeeding, mental health, and the risk of cardiovascular disease and metabolic syndrome - Breastfeeding and immunity - Implications of an anti-inflammatory response to enhancing the health effects of breastfeeding throughout women's lives

The company has begun human testing of its mRNA drugs for cardiovascular disease and cancer, and for vaccines against the flu, Zika, and chikungunya viruses.

The U.S. National Institutes of Health (NIH) has made major investments in network approaches in many areas, including cancer biology, cardiovascular and metabolic diseases, neurophysiology, and human genetics and genomics.

«Acute repeated spikes in blood sugar that you see with each dose of this drug have long - term impacts — and can predispose patients to the development of insulin - resistance Type 2 diabetes and cardiovascular disease,» said David Wright, associate professor in the Department of Human Health and Nutritional Sciences and corresponding author of the paper.

Professor Heiner Boeing, also from the German Institute of Human Nutrition, added, «In addition to the many noted benefits for cardiovascular health, and risk of lung disease and cancer, it is clear that dental health is yet another reason not to take up smoking, or to quit smoking now.»

The first group includes such diseases as type 2 diabetes and cardiovascular disease, whose incidence is linked to recent changes in human environment and lifestyle.

«If lowering of LDL cholesterol affects atherosclerosis in humans in the same way, our observations mean that clinically advanced plaques could be prevented if cholesterol - lowering treatments are administered early enough in individuals with increased risk of cardiovascular disease.

The study has produced more than 20 publications examining a range of complex human conditions, including cardiovascular disease, breast and lung cancer, and type I and II diabetes.

«As a man's fertility potential is often known in early life, our work suggests that the fatherhood status may provide insight into a man's risk of cardiovascular disease and death later in his life,» the researchers wrote in the Sept. 26 issue of the journal Human Reproduction.

There are two recent human studies, one showing an effect on cardiovascular disease and one Kaiser Permanente study on workers in China (in polycarbonate - manufacturing plants) showing effects on male sexual function.

Their blood sugar goes up, they get more gall - bladder and cardiovascular diseases, and they develop problems with insulin similar to human type II diabetes.

Researchers from the Gladstone Institutes have used human cells to discover how blood flow in the heart protects against the hardening of valves in cardiovascular disease.

«Inappropriate immune response to commensal bacteria and subsequent pathologic inflammation is a contributing factor to the pathogenesis and progression of many chronic human diseases, including inflammatory bowel disease, HIV / AIDS, viral hepatitis, cancer, cardiovascular disease, and diabetes,» says Sonnenberg.

They add: «What is similar between now and then is the human genetic material, our genome, including ancient polymorphisms that were uncovered to predispose the carrier to the development of atherosclerotic cardiovascular disease... however, our ancient ancestors were certainly susceptible to many other conditions, such as infectious diseases, nutritional deprivation, and trauma, which often resulted in death at an early age, before atherosclerotic heart disease had a clinical impact.»

However, in several chronic human diseases such as inflammatory bowel disease (IBD), HIV / AIDS, cancer, cardiovascular disease, and diabetes, the immune system attacks these normally beneficial bacteria, resulting in chronic inflammation and contributing to disease progression.

Acute sleep loss in humans is associated with increased appetite and insulin insensitivity, while chronically sleep - deprived individuals are more likely to develop obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease.

Worse, the new weight from trans fats showed up mostly around the abdomen, a pattern strongly associated with cardiovascular disease in humans.

Behaviors that evolved as survival mechanisms to ensure that an animal feeds itself become inconvenient and potentially detrimental side effects in industrialized human populations where cardiovascular disease, diabetes, and obesity, rather than starvation, pose greater risks to long - term survival.

Brominated fire retardants, used in many consumer products and known to cause hormonal irregularities, overstimulates an adrenal gland hormone in a way that may lead to the development of cardiovascular disease, new research in human cells finds.

Animals with gene mutations that significantly alter their circadian rhythms have shorter life spans, and circadian rhythm sleep disorders in humans can have profoundly negative effects, including increased risk for obesity, depression, cardiovascular disease and cancer.

And because their signal blocker is an antibody already in phase I clinical trials for cancer treatment, they're hoping to make a quick jump into human testing for cardiovascular disease.

It is no surprise, then, that having faulty protein kinases may lead to a number of human conditions, including cardiovascular diseases, cancer and diabetes.

Humans can overrule their body clocks, but at a price: People whose circadian rhythms are regularly disrupted — by frequent jet lag or shift work, for example — are more vulnerable to diabetes, obesity, cardiovascular disease, and cancer.

Omega - 6 and omega - 3 fatty acids are essential human nutrients, yet consuming too much omega - 6 and too little omega - 3 can increase the risk of cardiovascular disease, obesity, and diabetes.

Launched in 1972, the Dunedin Multidisciplinary Health and Development Study is as fundamental to human development as the Framingham Heart Study is to cardiovascular disease and the Nurses» Health Study is to women's health.

Roughly 75 % of disease - causing genes in humans are also found in the fruit fly, and most of the components found in human heart cells are also found in the fly heart, thus providing a model for studying cardiovascular changes.

Some bacteria can turn choline (and also carnitine) into trimethylamine N - oxide (TMAO), high levels of which predict cardiovascular disease in humans.

The Center, which collaborates with CiRA, is creating human, iPS - based disease models needed to accelerate drug development for a host of devastating for cardiovascular, viral and neurological illnesses.

This is the first study on humans to show that the fat composition of food not only influences cholesterol levels in the blood and the risk of cardiovascular disease but also determines where the fat will be stored in the body.

«Over the past ten years, several research groups, including our own, have shown the importance of certain immune cell subsets in preventing or exacerbating heart disease in mice, but we are just beginning to understand how the metabolism and function of these immune cells change during cardiovascular disease progression in humans,» says Hedrick.

Bethesda, Md. (January 24, 2018)-- A review of more than 80 studies reveals that changes in the immune cells of people with human immunodeficiency virus (HIV) infection may increase their risk of cardiovascular disease (CVD).

Dr. Conklin's research focuses on human genetics that lead to cardiovascular diseases, such as cardiac arrhythmias and cardiomyopathy.

Since they confer regulation on the majority of human genes, it is not surprising that microRNAs are involved in numerous biological processes, including cardiovascular, immunological, neurodegenerative, and psychiatric diseases and cancer.

Dysregulation of DDR and repair is closely associated with human diseases such as cancers, cardiovascular disease, neurodegenerative disorders and aging.

The challenge for the years to come is to convert data on new genes, gene defects and human genome variation in patients with genetic cardiovascular disease into functionally relevant information on the diverse pathophysiological mechanisms and clinical manifestations.

Recent genetic research in humans has implicated mutations in the gene for Tet2 as a risk factor for many different diseases of aging, including cancer, cardiovascular disease, and stroke.

Understanding the genetic basis of human age - related diseases, as well as normal aging, such as cardiovascular changes, age - related neurodegenerative disease, autoimmune disease, and diabetes constitutes an important step towards unraveling disease pathogenesis and risk prediction.

These highly competitive funds enable UCSF scientists to pursue research aimed at advancing understanding of human health and disease, and developing new therapies for neurological diseases, cancer, diabetes, cardiovascular disease, and a host of other conditions.

Each cell - based treatment approach is presented as a potential therapy for a specific disease or a disease category (e.g.: cardiovascular diseases, metabolic diseases, etc.), studied in animal models or in humans.

Moreover, PHENONIM - ICS is involved in European projects presenting a strong impact on human health: Interreg CARDIOGENE (Genetic mechanisms of cardiovascular diseases), GENCODYS (Genetic and epigenetic networks involved in cognitive dysfunctions), AgedBrainSYSBIO (Basic studies of brain aging), as well as projects in partnership with industry: MAGenTA (an Industrial Strategic Innovation project supported by Bpifrance about the treatment of major urogenital diseases) and CanPathPro (H2020 program), to develop a predictive modeling platform of signaling pathways involved in cancers.

The recent Nature paper «High - throughput discovery of novel developmental phenotypes» describes the systematic high - throughput phenotyping screens used in the knock out mice and gives insight into a variety of gene function while a strong correlation was found between genes causing lethality in mice and genes causing diseases in humans, including cardiovascular defects, spina bifida, and metabolic disorders, among many others.

For many human diseases, large - scale genomic studies have identified common genetic variants that occur more frequently in people with cardiovascular, autoimmune, inflammatory and infectious diseases, diabetes and asthma than in those without these diseases.