Sentences with phrase «human carriers of»

Such dramatic effects on brain size and function are unlikely in human carriers of BRCA1 mutations, the authors of the study note, but they propose the findings could shed light on the gene's role in brain evolution.

Not exact matches

Discount carriers like Southwest and JetBlue were reshaping the industry with cheap fares and an easy - to - understand business model: fly one type of plane, sell only economy - class seats and treat passengers like human beings.

The presence of the AIDS virus in an asymptormatic carrier of the disease may be indicated by a blood test designed to detect the human immunodeficiency virus (HIV) antibodies.

Some are better, some worse, carriers of divine justice; democracy is better fitted than either fascism or Communism to bring about the kind of human society willed by God.

Every authentic humanism considers each human life a carrier of an ultimate dignity that warrants respect.

If we establish the idea that people no longer have lifetime membership in the human family, the practice of abandonment could become widespread - strongly encouraged perhaps by insurance carriers to cut costs.

With a background in fashion design and an understanding of how clothing best supports the human body, Karin's goal was to make a carrier with maximum, all day comfort for herself and her son by focusing on ergonomic design.

«You can send a baby carrier, put a little note in the pocket and know that very soon that note will be in the human hand of a mom or dad who will know that someone in this country loves them.»

As well as being a School of Babywearing accredited consultant, she runs a very busy sling library and consultancy alongside her successful carrier making business, Rock Solid Slings and she's also a lone parent to 2 amazing human beings.

Researchers also included a human genetics study of approximately 188,000 people, which found that carriers of mutations that disable ANGPTL3 had nearly 40 percent fewer incidents of coronary artery disease as compared to those with fully functioning ANGPTL3.

After all, other humans are all potential disease - carriers, says Valerie Curtis, director of the Hygiene Centre at the London School of Hygiene and Tropical Medicine.

This novel technology is also highly suitable for confined spaces such as bomb shelters or bunkers, where removing moisture from the air is critical for human comfort, as well as for sustainable operation of delicate equipment in areas such as field hospitals, armoured personnel carriers, and operation decks of navy ships as well as aircrafts,» explained Assoc Prof Chua.

HUMANS AND PARASITES I read with interest in Mary Carmichael's «Halting the World's Most Lethal Parasite» the idea of vaccinating mosquitoes by using a human carrier to pass the vaccine on to the mosquito.

A marathoner himself, Carrier began to wonder about the role of endurance running in human evolution.

A predecessor to the TALOS, called the Human Universal Load Carrier (HULC), was shelved after it proved impractical, exhausting users instead of supercharging them.

«However, we were able to show for the first time that changes in this gene primarily cause Dowling - Degos disease and around half of the mutation carriers develop acne inversa,» emphasizes Damian Ralser, who is currently working on his doctorate at the Institute of Human Genetics.

Elegant, dainty, and deadly, it is the most common of all blood - sucking arthropods and the most important insect carrier of human disease, transmitting not only malaria but also yellow fever, dengue, West Nile virus, encephalitis, and the tiny worms that cause elephantiasis.

They also gained fame as the first carriers of messages designed for other civilizations, in the form of etched plaques about humans and Earth.

They add: «What is similar between now and then is the human genetic material, our genome, including ancient polymorphisms that were uncovered to predispose the carrier to the development of atherosclerotic cardiovascular disease... however, our ancient ancestors were certainly susceptible to many other conditions, such as infectious diseases, nutritional deprivation, and trauma, which often resulted in death at an early age, before atherosclerotic heart disease had a clinical impact.»

A 4 - nanometre wire of silicon, about 20 000 times thinner than a human hair, is called a «quantum wire», since the carriers within it are strongly confined in two dimensions but free to move long distances in the third dimension, along the wire.

It's estimated that 30 - 50 per cent of the global human population are carriers.

Quantum computing — using individual atoms as information carriers — could transform the way we study the world, solving problems that would take many human lifetimes for today's supercomputers in a matter of days.

At the federal level, Dr. Haywood serves on a National Human Genome Research Institute sponsored working group charged with examining the evidence regarding the clinical implications of sickle cell carrier status.

Mice with a homozygous SMN1 deletion are the offspring of heterozygous carriers, mimicking the SMA genetics in humans.

The key to the evolutionary success of fish — and their possible survival in future — may lie with a molecule that they ultimately bequeathed to humans: hemoglobin, the precious carrier of oxygen into our brain, heart, muscles and other organs.

This is a great example of a potential gene therapy target that still needs a fair amount of work to validate the thesis and the initial data, but having a large number of existing human carriers is a good sign on the safety front.

In animal models, E1 - deleted human adenoviral recombinants of the serotype 5 (AdHu5) have shown high efficacy as vaccine carriers.

This includes utilizing a modified chimpanzee virus as a vaccine carrier to induce an immune response against HIV, and a new therapeutic vaccine against human papillomavirus (HPV), a leading cause of cervical cancer.

We conclude that the large number of mouse mutants and human de novo mutations may be due to the combination of the Chd7 gene being a large target and the fact that many heterozygous carriers of the mutations are viable individuals with a readily detectable phenotype.

Lack of preexisting virus - neutralizing antibodies in the human population suggests that these novel adenoviral recombinants may provide improved vaccine carriers for use in humans.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Human pulmonary artery endothelial cells cultured with serum from homozygous carriers showed an increase in MCP - 1 release in carriers of the minor allele, with the difference eliminated upon addition of tocilizumab.

Furthermore, saturated fat has been shown to have numerous positive effects on health, such as improving liver health by encouraging the liver cells to get rid of their fat cells, improving the immune system's response by helping white blood cells to recognize and destroy invaders more effectively, enabling the absorption of fat - soluble vitamins by acting as their carriers, as well as improving hormonal activity by providing the building blocks for a variety of hormones that are essential to human health.

Albumin normally constitutes about 60 % of human plasma protein and plays an important role in regulating blood volume by maintaining the oncoosmotic pressure of blood needed to avoid edema, and by serving as the carrier for hydrophobic molecules, including lipid soluble hormones, bile salts, unconjugated bilirubin, free fatty acids (apoprotein), calcium, ions (transferrin), and some drugs (e.g., warfarin, phenobutazone, clofibrate & phenytoin).

This free diffusion without the aid of a carrier makes lauric acid a highly efficient source of energy for the human body.

This free diffusion without the aid of a carrier makes lauric acid is a highly efficient source of energy for the human body.

These vitamins are essential for a long list of physiological processes and biochemical reactions in the body; they serve as cofactors for enzymes and as carriers for electron transport between different processes involved in human metabolism and growth.

Fatih Akin — «In the Fade,» «The Edge of Heaven» Adolfo Aristarain — «Common Places,» «A Place in the World» David Ayer — «Suicide Squad,» «Fury» Nabil Ayouch — «Horses of God,» «Ali Zaoua» Siddiq Barmak * — «Opium War,» «Osama» Aida Begić * — «Children of Sarajevo,» «Snow» Emmanuelle Bercot — «Standing Tall,» «On My Way» Martin Butler — «Tanna,» «Contact» Patricia Cardoso — «Real Women Have Curves,» «The Water Carrier» Peter Ho - Sun Chan — «Dragon,» «Perhaps Love» Derek Cianfrance — «The Light between Oceans,» «Blue Valentine» Pedro Costa — «Horse Money,» «Blood» Garth Davis — «Lion» Bentley Dean — «Tanna,» «Contact» Lav Diaz * — «A Lullaby to the Sorrowful Mystery,» «Norte, the End of History» Carlos Diegues — «Orfeu,» «Bye Bye Brazil» Nelson Pereira dos Santos * — «How Tasty Was My Little Frenchman,» «Barren Lives» Nana Dzhordzhadze — «27 Missing Kisses,» «A Chef in Love» Ildikó Enyedi * — «Simon Magus,» «My Twentieth Century» Amat Escalante — «The Untamed,» «Heli» Safi Faye * — «Mossane,» «Lettre Paysanne» Tom Ford — «Nocturnal Animals,» «A Single Man» Goutam Ghose * — «Dekha,» «Paar» Jessica Hausner — «Amour Fou,» «Lourdes» Joanna Hogg — «Archipelago,» «Exhibition» Hannes Holm — «A Man Called Ove,» «Behind Blue Skies» Ann Hui — «A Simple Life,» «Summer Snow» Christine Jeffs — «Sunshine Cleaning,» «Sylvia» Barry Jenkins * — «Moonlight,» «Medicine for Melancholy» Alejandro Jodorowsky * — «The Holy Mountain,» «El Topo» Kim Ki - duk * — «3 - Iron,» «Spring, Summer, Fall, Winter... and Spring» Zacharias Kunuk — «Searchers,» «The Fast Runner (Atanarjuat)» Mohammed Lakhdar - Hamina * — «Chronicle of the Years of Embers,» «The Winds of the Aures» David Mackenzie — «Hell or High Water,» «Starred Up» Sharon Maguire — «Incendiary,» «Bridget Jones's Diary» Theodore Melfi — «Hidden Figures,» «St. Vincent» Kleber Mendonça Filho — «Aquarius,» «Neighboring Sounds» Brillante Mendoza — «Thy Womb,» «Kinatay» Márta Mészáros * — «Diary for My Children,» «Adoption» Takashi Miike — «13 Assassins,» «Ichi the Killer» Orlando Montiel — «The Son of No One,» «A Guide to Recognizing Your Saints» Jocelyn Moorhouse — «The Dressmaker,» «Proof» Kira Muratova — «The Tuner,» «The Asthenic Syndrome» Héctor Olivera — «El Mural,» «Funny Dirty Little War» Idrissa Ouedraogo * — «Tilaï,» «Yaaba» Jordan Peele * — «Get Out» Mohammad Rasoulof * — «Manuscripts Don't Burn,» «Goodbye» Eran Riklis * — «The Human Resources Manager,» «Lemon Tree» Arturo Ripstein — «Deep Crimson,» «The Beginning and the End» Guy Ritchie — «Sherlock Holmes,» «Lock, Stock and Two Smoking Barrels» Anthony Russo — «Captain America: Civil War,» «Captain America: The Winter Soldier» Joseph Russo — «Captain America: Civil War,» «Captain America: The Winter Soldier» Mrinal Sen * — «The Case Is Closed,» «In Search of Famine» Cate Shortland — «Lore,» «Somersault» Peter Sollett — «Freeheld,» «Raising Victor Vargas» Juan Carlos Tabío — «Guantanamera,» «Strawberry and Chocolate» Rawson Marshall Thurber — «Central Intelligence,» «Dodgeball: A True Underdog Story» Johnnie To — «Election,» «Exiled» Tran Anh Hung * — «Norwegian Wood,» «The Scent of Green Papaya» Pablo Trapero — «The Clan,» «Lion's Den» Athina Rachel Tsangari — «Chevalier,» «Attenberg» Paula van der Oest — «Black Butterflies,» «Zus & Zo» Susanna White — «Our Kind of Traitor,» «Nanny McPhee Returns» Martin Zandvliet * — «Land of Mine,» «A Funny Man»

In reviewing LTLT competencies reflected in national curricula, it is also important to note that while some countries have specific subjects dedicated to LTLT competencies such as peace and education, civics, human rights or moral education, others may rely upon «carrier» subjects such as social science and history for the less explicit transferal of LTLT illustrative competencies.

Tinti is a writer gifted beyond her years, both literary in her perceptions — «the sailboat passed a cargo ship the length of an aircraft carrier, stretching across the surface like a giant guarding the edge of the world» — and possessing a thoroughgoing comprehension of the human condition, our sometimes desperate search for love and family, the rage we often feel as we stumble through our ignorance and past our fear to confront our mortality.

Casters or wheels make carriers more convenient, and an extra door on the top of the carrier lets the human see how the pet is managing.

«Trends in the colors, textures and features of pet carriers often mirror or follow human handbag fashion trends.»

Unlike human travel, pets must travel with the same air carrier for all legs of their transportation.

Wildlife species are the only carriers of the disease, with occasional cases affecting domestic animal and human populations

Identification of such genes could lead to carrier testing, a better understanding of the disease and long term better treatments for the disease in both dogs and humans.

It is not right to have hundreds of animals kept free - roaming in a facility (building) where it is a known fact that some are carriers of diseases such as feline leukemia, for example, which is equivalent to human AIDS.

Most of the time the cats will hide in their carriers when humans are present.

Public Health Issues «The public health trouble with TNR,» argues HAHF, «is that even vaccinated stray cats are still carriers of many significant infectious diseases and are able to transmit those diseases to other animals and humans.»

The public health trouble with TNR is that even vaccinated stray cats are still carriers of many significant infectious diseases and are able to transmit those diseases to other animals and humans.

Dogs are the primary carriers of rabies to human hosts.