Using mouse models and
human cell culture models, Dr. Shresta and her team dissect the protective versus pathogenic mechanisms of the immune system in response to these viral infections.
Adding nanotechnology - based optoelectronic sensors to
human cells cultured on a chip keeps the cells healthy long enough to replace animal testing with a human liver - on - a-chip.
Follow - up tests
in human cell cultures confirmed that MIR168a interferes with production of a cholesterol - clearing protein.
The research showed the beta - lactamase genes in Klebsiella pneumoniae were on all the time, whether or not the bacteria were
infecting human cell cultures.
Because hers were the
first human cells cultured continuously for use in research, Lacks» identity was revealed in a scientific journal in 1971 in reference to the landmark accomplishment.
A study from Dr. Dusty Miller's laboratory indicates that Jaagsiekte sheep retrovirus (JSRV) infects both sheep and
human cells cultured outside the body and does so by attaching to a receptor on the surface of lung cells.
We thank K. Saul, D. Harlow and K. Ellison for conducting histology and behavioral testing (Department of Neurosurgery, UC Denver) and Michelle Lacagnina (Department for Biomedical Genetics, University of Rochester, NY) and Laurie Baxter (Surgical Pathology, University of Rochester, NY) for assistance
with human cell cultures, and Brendan Carlin for assistance with RT - PCR analysis (Department for Biomedical Genetics, University of Rochester, NY).
Specifically, the Ignatius laboratory will study tumorigenic cell populations that self - renew and metastasize using a combination of zebrafish, murine xenograft and
human cell culture systems.
Aguayo told TreeHugger that in studies
of human cell cultures, potassium bromate has been seen to have a genotoxic effect, or in other words, causes damage to the cell's DNA.
Studies are underway to define the particular interferon regulatory factor and ISG mechanisms through which both the STAT1 - dependent and STAT2 - independent pathways contribute to protection vs. pathogenesis using both mouse models and
human cell culture models.
Though Li's adhesive has been tested only
in human cell cultures and in lab animals, another bio-inspired glue has made its way into human trials.
By activating the Ret receptor, the scientists were able to prevent in flies and
human cell cultures the degeneration of mitochondria, which is caused by a gene defect related to Parkinson's disease.
While TALENS have been previously used to edit the genomes of animal and
human cell cultures, applying them to the mosquito genome is a new approach, according to Adelman.
His postdoctoral work focuses on investigating novel molecular regulatory pathways involved in mitigating genotoxic stress using Drosophila melanogaster and
human cell culture model and cellular senescence.