Sentences with phrase «human cell engineering»

Dr. Sadelain's research focuses on human cell engineering and cell therapy to treat cancer and hereditary blood disorders.

Not exact matches

Technology by Cellectis allows cellular engineering, and a human trial of the company's work in editing blood cells will be presented at the upcoming American Society of Hematology.

Thirty years ago he engineered a bacterial strain to produce an HIV enzyme so he could study how it enables HIV to infect human cells.

But in June, the Chan Zuckerberg Initiative — the philanthropic organization in Palo Alto, California, that funds the Biohub — contributed an undisclosed amount of money and software - engineering support to the Human Cell Atlas data platform, which will be used to store, analyse and browse project data.

Because the human cells had been genetically engineered to express green fluorescent protein, the tiny blobs showed up in brilliant lime through the transparent window that the scientists glued into the mice's skull.

To see whether this also applies to humans, the team engineered stem cells from people with and without Down's syndrome and injected them into mice.

On to the blocks were poured a mixture of recombinant human bone morphogenic protein (BMP) powder — a genetically engineered protein that causes cells to ossify or become bone — and liquid bone marrow containing stem cells.

Then, to boost the number of cells, which is another hurdle in tissue engineering, the researchers mixed the chondrocytes with human mesenchymal stem cells from bone marrow.

To hunt for drugs that target these cells, Piyush Gupta, a molecular biologist at the Broad Institute at the Massachusetts Institute of Technology, and colleagues genetically engineered ordinary human cells so that they acquired some of the properties of cancer stem cells, including being impervious to chemotherapy.

However, some mice experienced dangerous levels of brain swelling, a side effect of the immune response triggered by the engineered cells, the researchers said, adding that extreme caution will be needed to introduce the approach in human clinical trials.

A technique that involves genetically engineering brain cells so that they fire in the presence of certain drugs has been used to treat epilepsy in rats, and it could soon be tested in humans.

«We are the first to engineer a whole liver organ with human cells,» says Shay Soker, a co-developer of the livers at Wake Forest University Baptist Medical Center in North Carolina.

Professor Ali Tavassoli, who led the study with colleague Dr. Ishna Mistry, explains: «In an effort to better understand the role of HIF - 1 in cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environment.

«One of the broader goals of our research is to make regenerative treatments more accessible and clinically relevant by developing easy, efficient and cost - effective ways to engineer human cells and tissues,» said Shyni Varghese, a bioengineering professor at UC San Diego and senior author of the study.

The man who first sequenced the human genome and designed the first synthetic cell explains why simple algae — and some genetic engineering — may hold the key to our future

To fully realize the field's clinical potential, the tissue engineers of the future must possess «a broad understanding of basic sciences (including biology, chemistry, and physics) and a sophisticated understanding of human pathophysiology, stem cell biology, and tissue mechanics.»

«Genetic engineering of human stem cells has not been used for disease - associated genomic deletions,» said Dr. Papapetrou.

Tina Hesman Saey covered researchers» arguments for and against this type of genetic engineering in «Editing human germline cells debated» (SN: 5/30/15, p. 16).

Tufts University biomedical engineers recently published the first report of a promising new way to induce human mesenchymal stem cells (or hMSCs, which are derived from bone marrow) to differentiate into neuron - like cells: treating them with exosomes.

An initial library of 15 biodegradable particle formulations was tested for their ability to carry siRNAs into human glioblastoma cells that were genetically engineered to make green fluorescent protein (GFP).

In tests on human brain cells engineered to make more normal prions than usual, Hooper found that the cells secreted far less amyloid beta peptide than they would ordinarily.

In fact, recent breakthroughs in the creation of human induced pluripotent stem cells (IPS) and the engineering of biodegradable scaffolds to create tissues may ultimately be applicable to most health conditions known to humankind.

Once Katlyn arrived in May 2007, Candotti and his team removed stem cells from her bone marrow and exposed them to the engineered retrovirus, creating a human - virus hybrid.

A company called Hematech is already breeding genetically engineered cattle (derived from cloned stem cells) that produce human antibodies to fight bacterial infections, and the animals» welfare is not compromised in any way.

Biology, microbiology / human genetics, medicinal chemistry, mechanical engineering / robotics, molecular & cell biology, computer science

An ear scaffold, left, provides the structure to grow human cells.A kidney stripped of cells, right, awaits an injection of human kidney cells, part of the process of engineering a new organ.

In a boost for a controversial theory of aging, mice engineered to make a human protein that sponges up cell - damaging molecules live 19 % longer than other mice.

In addition, harmine treatment tripled the number of beta cells and led to better control of blood sugar in three groups of mice engineered to mimic human diabetes.

They found that indeed, they do, and that stimulating these cells led them to kill cells infected with HIV - 1 derived from latently infected cells, both in culture and in mice engineered to have a human immune system.

Fourteen participating teams each engineered two chemotaxis models, the amoeba Dictyostelium discoideum (Dicty), and the human cell line HL60, to run a millimeter - long maze of interconnected, orthogonal channels designed to mimic the cell's natural environment.

Kotton built a reporter gene that glowed green when the stem cells first expressed Nkx2 - 1, and Hawkins engineered the same gene into human cells.

T - VEC, also called talimogene laherparepvec, is a human herpes simplex virus that is genetically engineered to bring T cells into a tumor and induce an antitumor response.

Shah and his team induced toxin resistance in human neural stem cells and subsequently engineered them to produce targeted toxins.

The researchers created the nanosponges by separating the membranes of human red blood cells from their internal contents and stabilizing the membranes with an engineered core designed to absorb the toxins produced by pathogenic bacteria.

Even more encouraging, the engineered tissues still continued to produce human neural, cartilage, and liver cell proteins, the team reports online this week in the Proceedings of the National Academy of Sciences.

They used the gene editing technology CRISPR to engineer a series of human embryonic stem cell lines, which were identical apart from the number of DNA repeats that occurred at the ends of their HTT genes.

A team of engineers at MIT has harnessed viruses to make components for a remarkable new kind of battery, half the size of a human cell and far more efficient than your usual AAA.

Rather than artificially triggering cancer by engineering genetic mutations, this model more closely mimics human liver cancer in that tumors develop as a natural consequence of non-alcoholic steatohepatitis (NASH), a chronic metabolic disorder that causes liver damage, fibrosis and numerous cell mutations.

In mice engineered so their macrophage cells would mimic those of people, expressing the human SIRPα protein, nanoparticles tagged with the CD47 peptide passports stuck around in the circulation rather than being gobbled up.

Using a combination of human or specially engineered mouse cells in vitro and in vivo animal models, study senior investigator Judy Lieberman, MD, PhD; study lead investigator Farokh Dotiwala, PhD, with a team lead by the Brazilian parasitologist Ricardo Gazzinelli, DSc, DVM, found that when an immune killer cell, such as a T - cell or natural killer (NK) cell, encounters a cell infected with any of three intracellular parasites (Trypanosoma cruzi, Toxoplasma gondii or Leishmania major), it releases three proteins that together kill both the parasite and the infected cell:

The researchers, led by University of California, San Diego neuroscientist Mark Tuszynski, took skin cells from the patients, grew them up in a culture dish and genetically engineered them to make human nerve growth factor (NGF).

The first human trials testing genetically engineered cells missing the CCR5 receptor, begun in 2009, have been small but impressive.

«With Teresa Woodruff's research using Draper's human organ system platform, we have a compelling demonstration of the importance of a microenvironment that permits cells to function in vitro as they would in vivo, and the power of being able to interconnect organ models on a platform and operate them in a stable and precise manner for weeks to months,» said Jeffrey T. Borenstein, a biomedical engineer at Draper.

A technique that involves genetically engineering brain cells so that they fire in the presence of certain drugs has been used to treat an epilepsy - like condition in rats, and it could soon be trialled in humans.

Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.

«Our group pioneered the development of cell culture technology for harvesting large numbers of stem cells from human bone marrow and human umbilical cord blood,» Dr. Yeh said, noting that stem cells from these two sources are abundant and can be guided into different types of cells using tissue engineering.

Incorporating advances in engineering, cell culture, genetics, and biomechanics, the «living» robot brings Parker's dream of a humanmade human heart a step closer.

To overcome this hurdle, researchers genetically engineered human T cells to produce a CAR protein that recognizes a glycopeptide found on various cancer cells but not normal cells, and then demonstrated its effectiveness in mice with leukemia and pancreatic cancer.

When pancreas cells containing clumps of misfolded IAPP, taken from an engineered diabetic mouse, were mixed in a dish of healthy human pancreas cells, it triggered the clumping of IAPP in the human cells.

To find out, the team engineered baby hamster kidney cells to express the human ACE2 receptor.