Sentences with phrase «human cell samples»

In human cell samples, astaxanthin put the brakes on a cascade of reactions caused by UVA rays, which suggests it keeps skin tight and reduces wrinkles.

Additionally, back then, tests in human cell samples and in rabbits, showed that simvastatin (Zocor) seemed to activate a pathway through which cells communicate and act very similar to a naturally - occurring growth factor.

FANTOM5 has generated single molecule CAGE profiles for 574 primary human cell samples, each sequenced to a median depth of ~ 4 million mapped tags per sample.

Not exact matches

The National Institutes of Health (NIH) has allowed a contract for the dissemination of embryonic stem cell lines approved for US government funding to lapse, shuttering a key stem cell bank, and doubling the price researchers pay for samples of some human embryonic stem cell (hESC) line... from $ 500 per vial of frozen cells to $ 1,000.

To determine how the cells switch from one type to another, they took three human uterine carcinosarcoma samples and sequenced the genomes of cells in two parts of each tumor: the carcinoma and sarcoma components.

The researchers detected this SMN long noncoding RNA, or lnc - RNA (pronounced «link RNA») for short, in human embryonic kidney cells, brain cell samples and neurons derived from the stem cells of healthy people and those with spinal muscular atrophy type I and II.

But scientists published in Cell Reports that they've discovered a way to regenerate those cells in mouse, primate and human tissue samples.

This study built on previous research from the Sundrud lab, which showed that when TH17 cells entered the intestine in human tissue samples, they increased the expression of a gene called MDR1.

As reported June 13 in Cell Reports, a topical drug penetrated and tanned laboratory samples of live human skin, absent the sun.

In cancer research, our goal is to be able to start with a sample of human tissue, extract many cells of interest, and perform genetic analysis upon each of them separately.

The biobank of MedUni Vienna and Vienna General Hospital is a central service facility dedicated to the storage of human tissue, cell material and body fluids for more in - depth diagnosis, academic research projects and clinical tests, as well as working - up samples by way of a medical service.

An analysis of the HPV16 genome from 5,570 human cell and tissue samples revealed that the virus actually consists of thousands of unique genomes, such that infected women living in the same region often have different HPV16 sequences and variable risks to cancer.

HBI member V. Wee Yong, PhD and research associate Susobhan Sarkar, PhD, and their team including researchers from the Department of Clinical Neurosciences and the university's Southern Alberta Cancer Research Institute, looked at human brain tumor samples and discovered that specialized immune cells in brain tumor patients are compromised.

The team found that exposing samples of human glioblastoma tumours grown in a dish to the Zika virus destroyed the cancer stem cells.

To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single - cell level, gene expression in samples from six early - stage human tumors.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

While testing the effect of many normal, non-cancerous, human cells on the sensitivity of cancer cells to chemotherapy, they found a specific sample of normal human skin cells that rendered pancreatic cancer cells resistant to gemcitabine.

These triple - mutant H7 hemagglutinins also successfully latched onto cells in samples of human trachea tissue.

To validate their computer modeling predictions, researchers performed experiments in human cancer cell lines, mouse liver samples and primary human hepatocytes.

Researchers have used radioimmunotherapy (RIT) to destroy remaining human immunodeficiency virus (HIV)- infected cells in the blood samples of patients treated with antiretroviral therapy, offering the promise of a strategy for curing HIV infection.

These results were also confirmed on human cells and tissue samples.

The Ogretmen laboratory screened previously reported microarray data sets of several human tumor tissues (metastatic head and neck squamous cell carcinoma, melanoma, and renal cell carcinoma) and showed that, in these samples, only the levels of CerS4 were significantly decreased.

The research team analyzed BRAF inhibitor resistance in melanoma cell lines, mice bearing human melanoma tumors, and in human tumor biopsy samples.

The scientist tested their set - up using frozen human skin cells, segments of pig heart tissue, and sections of pig arteries in volumes almost 20 times larger than previously attempted samples.

They confirmed low levels of miR - 184 expression in human glioma tissue samples and cultured cell lines as well as an increase in the expression of SND1 compared to normal brain tissue.

One uses primary hepatocytes obtained from livers donated for transplant; the second uses stem cells derived from human skin samples and guided into hepatocyte - like cells, Bhatia says.

Palsson and his team were interested in red blood cells because they are the simplest human cells and are readily available from blood samples.

They then conducted biochemical analyses to identify neuroligin - 3, confirm that the protein could stimulate tumor growth in cultured samples of several kinds of human high - grade gliomas and study which signals the protein uses within glioma cells to promote their growth.

The kit contains human cells and DNA extracted from them, along with the results of various tests carried out on the samples by a group of molecular biologists.

They found that human blood samples contained T cells specific for all 20 versions of the virus.

She and colleagues examined DNA from individual brain cells taken from three donated human brains and tested bulk samples from the hippocampus (an area important for learning and memory) and the frontal cortex (where most thinking and decision making is thought to happen).

To better understand the intestine in its normal and pathological states, researchers have created «organoids» by isolating intestinal stem cells from human biopsy samples.

It demonstrates that alterations in these cells lines do indeed match changes in samples of human bladder cancer.

The study of human astrocytes has faced issues related to access (samples of living tissue must be obtained from brain cancer or epilepsy surgeries or fetal tissue) and purification (breaking apart astrocytes away from other cells often killed them and many experiments ended in failure).

Even more promising, Cui has sampled a group of human volunteers and found that 10 to 15 percent have similar super cancer - fighting white blood cells.

Using human pancreatic samples and mouse models, the HSPH researchers — with colleagues from Harvard Medical School, the Broad Institute of Harvard and MIT, and the Université Libre de Bruxelles — sought to tease apart the mechanisms of beta cell failure in T1D.

When tested in laboratory samples of leukemia cells and in animals with human - like leukemia, the approach caused cancer cells to die much more quickly than with conventional targeted therapies.

Scientists at the University of Luxembourg have succeeded in turning human stem cells derived from skin samples into tiny, 3 - D, brain - like cultures that behave very similarly to cells in the human midbrain.

But the scientists can't be certain these cells are perfect matches for native human motor neurons since it's difficult to obtain samples of cultured motor neurons from adult individuals.

Using an antibody that recognizes the CD68 antigen we performed immunohistochemical analysis on these human samples and calculated the percentage of CD68 expressing cells (Figure 9).

Experimental models include yeast, mammalian and human cell lines, mutant mouse models and tumour samples.

MiRNA - seq and mRNA - seq will be carried out from the same RNA sample thereby integrating the mRNA and miRNA «sequenomes» of infected human cells most relevant to human toxoplasmosis.

As the Joslin team reports in the journal Nature Medicine, the work began with taking samples of both brown and white precursor cells from four human subjects and genetically modifying these cells to «immortalize» them for long life in a Petri dish.

A proprietary bioinformatics tool for the detection of aging biomarkers in DNA samples from somatic cells of human and mouse;

Studies in mouse models will permit extension of the human study to parameters that can not be assessed with human samples, and enable selective analyses of antigen - specific T and B cells.

• Detect Zika virus in blood and urine samples within hours and distinguish between its African and American strains • Distinguish between Zika and dengue • Discriminate different types of bacteria, like E. coli • Detect cancer cell mutations • Detect antibiotic resistance genes • Read human genetic information from saliva sample

«If we can pinpoint which genes control the development of each neuron type, we can generate them in the petri dish from a single sample of human skin cells,» said Dr. Huang.

As outlined below, we used a microfluidic quantitative PCR (qPCR) system to elucidate the gene expression profiles of individual human oocytes and small numbers of cumulus cells using a combination of a large number of samples and targets [12], and then extended our studies via the use of parthenogenesis, in conjunction with gene expression profiling, as a functional assay of cytoplasmic maturation of oocytes.

In particular, this meeting will focus on addressing the technological challenges and opportunities presented by the Human Cell Atlas in areas including large - scale single - cell RNA sequencing, spatially - resolved methods, single - cell proteomics, epigenomics, and sample handlCell Atlas in areas including large - scale single - cell RNA sequencing, spatially - resolved methods, single - cell proteomics, epigenomics, and sample handlcell RNA sequencing, spatially - resolved methods, single - cell proteomics, epigenomics, and sample handlcell proteomics, epigenomics, and sample handling.

Additionally, we clarified the role of iNKT cells in human asthma by carefully enumerating cell numbers in airway samples from asthma and COPD patients.