Sentences with phrase «human cells cultured on»

Adding nanotechnology - based optoelectronic sensors to human cells cultured on a chip keeps the cells healthy long enough to replace animal testing with a human liver - on - a-chip.

Not exact matches

While other papers have examined these mutations using expensive and time - consuming experiments on live ferrets and laboratory cell cultures, Deem and Melia Bonomo used the pEpitope method to rapidly calculate how much the egg - passage mutations would decrease vaccine efficacy in humans.

Scientists are forced either to experiment on whole animals, which is expensive, raises ethical issues and may not predict effects in humans, or to perform tests on microscopic human cells found in tissue cultures, which have been altered to live forever and bear little relation to actual living, breathing people.

The Wyss team believes the ability of the human gut - on - a-chip to culture the microbiome with human gut cells also holds promise for the field of precision medicine, where a patient's own cells and gut microbiota could one day be cultured inside a gut - on - a-chip for testing different therapies and identifying an individualized treatment strategy.

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

One week, the pair went to a conference to present a poster on the aging of human cells in culture.

Potti and his colleagues began by testing chemotherapy drugs on cultured cell lines from human tumors, such as from the lung, breast, or ovary.

Some of the leading non-animal tests are conducted on cell cultures, human and animal corneas from eye banks, corneal tissue cultures, and frozen corneas supplied by hospitals.

Experiments and observations may be conducted on humans, animals, cell cultures, chemical platforms, etc..

By analyzing chemical changes of the IRS - 2 protein in immortalized cultures of human white blood cells, it determined that IRS - 2 appeared in two different forms — «on,» which allows the signal to pass through, and «off,» which stops the signal from activating the cells into M2 macrophages.

Human nasal epithelial cells, cultured on a microchip, react to air pollutants just like they would in the upper airway.

In a previous related study published in the Journal of Materials Science: Materials in Medicine, the same team of NTU scientists found that fish scale - derived collagen would induce human umbilical vein endothelial cells to express 2.5 times more of a specific type of collagen responsible for blood vessel formation, as compared to endothelial cells cultured on bovine collagen.

Although no tests have yet been done on real wounds, experiments on cultured human skin cells have been encouraging, he says.

protected animals»); studies on in vitro systems (whole perfused organs, tissue slices, cell and tissue cultures, and subcellular fractions); and human studies (including estimations of occupational and environmental exposure, postmarketing surveillance, epidemiology, and the ethical and strictly controlled use of human volunteers).

One postdoc presents data on her efforts to develop an organoid model for small - cell lung cancer; another reports progress on culturing hormone - secreting organoids from human gut tissue.

The test procedure is performed on an in vitro skin model built at Fraunhofer IGB from human skin cells in special culture dishes.

«In the last few years, it has become possible to order cultures of human cells for testing, but they're grown on a plate, a two - dimensional environment,» says Radisic.

Prior research with cultured tissue had shown that a mix of chemicals could change bone marrow stem cells from mice to those resembling brain cells, but when a team led by neurologist Lorraine Iacovitti of Thomas Jefferson University in Philadelphia tried the same brew on human cells, the number altered was modest.

The research showed the beta - lactamase genes in Klebsiella pneumoniae were on all the time, whether or not the bacteria were infecting human cell cultures.

The treatment did a lot to prevent cell migration, a key mechanism in metastasis, in experiments on laboratory cultures (in vitro) of cancerous human cells.

Sood and his team first studied the effects of stress hormones on human ovarian cancer cell anoikis in culture.

The investigators studied application of various doses of a common PBDE flame retardant on human adrenal cells in culture dishes and compared the effects with those of only the vehicle, the inactive substance used to deliver the chemical.

In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channel.

Before toying with worms, the S.U.N.Y. Buffalo team tried out their technique on cultures of human embryonic kidney cells and neurons from a rat hippocampus, a part of the brain integral to memory.

If the cells grew on culture plates, the team inferred that the human gene could fill in for its yeast equivalent.

When the Cornell team cultured human breast cancer cells on matrix deposited by fat - derived cells from obese mice, the cancer cells grew faster than they did on the matrix of cells from slimmer mice.

Further testing of this culture method on kidney progenitor cells derived from human iPS cells resulted in four times the total amount of cells over 8 days.

«The resulting hydrogel composed of physically self - assembled CarHC polymers exhibited a rapid gel - sol transition on light exposure, which enabled the facile release / recovery of 3T3 fibroblasts and human mesenchymal stem cells (hMSCs) from 3D cultures while maintaining their viability.»

It is a continuation of previous research, published in 2011, that focused on the effect of decitabine on glioblastoma human cell cultures.

To ensure that the glial cell - to - neuron conversion method is not limited to rodent animals, Chen and his team further tested the method on cultured human glial cells.

At the time, his varied interests — in the use of skin cell culture to treat burns, in human tissue cultures, and in biopharmaceutical production — led him to do his final year, 6 - month project on culture in a bioreactor.

«First, we must bear in mind that the study was done on human cancer cells cultured in the laboratory, since it would be unethical to do it in humans.

In work published on 24 November in the journal Nature biotechnology, Anselme Perrier's team at I - Stem identified a recurrent anomaly in the genome of human embryonic stem cells left in culture for too long.

In cultured human cells and in rabbits with implanted stents, Finn and colleagues showed that metformin augmented the effect of mTOR inhibitors on regrowth of the blood vessel lining.

Bartosz Balana (Ravens, TUD)-- «Influence of culture conditions on differentiation and bioelectrical properties of human mesenchymal stem cells» (2005)

Stem cell culturing of human ES and iPS cells on recombinant laminin matrices is easy and efficient.

Buy human recombinant laminins from BioLamina - culture stem cells, differentiate to neurons, RPE cells, cardiomyocytes and other cells on their specific laminin isoform.

Differences between in vitro viability and differentiation and in vivo bone - forming efficacy of human mesenchymal stem cells cultured on PCL - TCP scaffolds.

All the hES and human induced pluripotent stem cell lines were confirmed to be genetically stable and pluripotent in in vivo and in vitro assays after extensive culturing on the new substrata.

Here, Kate presents her work on that show that culture of human ES cells on human recombinant laminin - 521 and laminin - 111 substrates significantly improve hepatocyte differentiation, maturation, function and stabilization of phenotype compared to Matrigel cultured cells.

«Our experimental model represents a promising technique to culture human liver cells and prepare them for transplantation on a biodegradable polymer scaffold into the peritoneal cavity,» concluded Dr. Pollok.

Effect of preculturing human satellite cell cultures in increasing concentrations of insulin on the activity constant A0.5 of GS.

Effect of preculturing human satellite cell cultures in increasing concentrations of insulin on the basal and insulin - stimulated glucose transport activity in cultures of human myofibers.

A study from Dr. Dusty Miller's laboratory indicates that Jaagsiekte sheep retrovirus (JSRV) infects both sheep and human cells cultured outside the body and does so by attaching to a receptor on the surface of lung cells.

The primary epithelial cells are expanded as 3D organoids, dissociated, and cultured on a porous membrane within a microfluidic device with human intestinal microvascular endothelium cultured in a parallel microchannel under flow and cyclic deformation.

The «heart - on - a-chip,» which builds off previous successful iCHIP research on the peripheral and central nervous systems, involves the use of human cardiac cells cultured for up to nine days on the engineered chip.

It is also worthy to mention that human ES cells and iPS cells could be maintained on the HFF cells with the conventional human ES culture medium (Li et al, unpublished data).

He was the first to describe the successful culturing of human embryonic germ cells and published a landmark 1998 paper on human primordial germ cells.

Labelled outer segments were washed, resuspended in human foetal RPE medium and seeded onto iPS - RPE cells cultured on gelatin - coated 35 mm dishes.

About the «Human Emulation System» Powered by Organs - On - Chips Technology Based on the Organs - on - Chips technology, Emulate has created a new living Human Emulation System ™ that provides a real - time window into the inner workings of human biology and disease — offering researchers a new technology designed to predict human response with greater precision and detail than today's cell culture or animal - based experimental tesHuman Emulation System» Powered by Organs - On - Chips Technology Based on the Organs - on - Chips technology, Emulate has created a new living Human Emulation System ™ that provides a real - time window into the inner workings of human biology and disease — offering researchers a new technology designed to predict human response with greater precision and detail than today's cell culture or animal - based experimental testinOn - Chips Technology Based on the Organs - on - Chips technology, Emulate has created a new living Human Emulation System ™ that provides a real - time window into the inner workings of human biology and disease — offering researchers a new technology designed to predict human response with greater precision and detail than today's cell culture or animal - based experimental testinon the Organs - on - Chips technology, Emulate has created a new living Human Emulation System ™ that provides a real - time window into the inner workings of human biology and disease — offering researchers a new technology designed to predict human response with greater precision and detail than today's cell culture or animal - based experimental testinon - Chips technology, Emulate has created a new living Human Emulation System ™ that provides a real - time window into the inner workings of human biology and disease — offering researchers a new technology designed to predict human response with greater precision and detail than today's cell culture or animal - based experimental tesHuman Emulation System ™ that provides a real - time window into the inner workings of human biology and disease — offering researchers a new technology designed to predict human response with greater precision and detail than today's cell culture or animal - based experimental teshuman biology and disease — offering researchers a new technology designed to predict human response with greater precision and detail than today's cell culture or animal - based experimental teshuman response with greater precision and detail than today's cell culture or animal - based experimental testing.