Sentences with phrase «human cells from the patient»

In lab dishes, Liu's team corrected a mutation in human cells from a patient with an iron - storage blood disorder called hereditary hemochromatosis.

«It is exciting that they have generated human cells from the patient material,» says stem cell researcher Jeffrey Rothstein of Johns Hopkins University in Baltimore, Maryland, who also studies ALS.

Not exact matches

As we read this history, the furor over stem cells was fueled by numerous factors: the near - universal human desire for magic; patients» desperation in the face of illness and their hope for cures; the belief that biology can now do anything; the reluctance of scientists to accept any limits (particularly moral limits) on their research; the impact of big money from biotech stocks, patents, and federal funding; the willingness of America's elite class to use every means possible to discredit religion in general; and the need to protect the unlimited abortion license by accepting no protections of unborn human life.

They stripped the knee joints of calves of all their cells with detergents and enzymes and then, based on digitized x-ray images from an anonymous patient, had machines carve them into cubic - centimeter - size human jaw joints.

«I'm working with Professor Richard Oreffo and Dr Rahul Tare from the University's Centre for Human Development, Stem Cells and Regeneration who are trying to create and grow cartilage in the lab using a patients» own (autologous) stem cells to then be implanted back into the patient if they have a cartilage defect,» she explCells and Regeneration who are trying to create and grow cartilage in the lab using a patients» own (autologous) stem cells to then be implanted back into the patient if they have a cartilage defect,» she explcells to then be implanted back into the patient if they have a cartilage defect,» she explains.

The Porteus team started with human stem cells from the blood of patients with sickle cell disease, corrected the gene mutation using CRISPR and then concentrated the human stem cells so that 90 percent carried the corrected sickle cell gene.

If the procedure works in humans, it would enable donated livers from humans, and possibly even from pigs, to be re-coated with a patient's own cells, reducing the likelihood of organ rejection.

HBI member V. Wee Yong, PhD and research associate Susobhan Sarkar, PhD, and their team including researchers from the Department of Clinical Neurosciences and the university's Southern Alberta Cancer Research Institute, looked at human brain tumor samples and discovered that specialized immune cells in brain tumor patients are compromised.

Abba Zubair, M.D., Ph.D, believes that cells grown in the International Space Station (ISS) could help patients recover from a stroke, and that it may even be possible to generate human tissues and organs in space.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

In addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.

By promoting DNA demethylation, high - dose vitamin C treatment induced stem cells to mature, and also suppressed the growth of leukemia cancer stem cells from human patients implanted in mice.

Pre-clinical studies have shown it to be effective in eliminating a number of different kinds of cancers cells, including cancer stem cells from human breast cancer patient biopsies.

In humans, a comparison of bone marrow from 14 normal bone marrow donors, 35 multiple myeloma patients and 11 patients with a noncancerous condition called monoclonal gammopathy of undetermined significance (MGUS) showed that Runx2 levels were significantly higher in the multiple myeloma cells.

We also reactivated insulin production in human pancreatic cells from type 1 diabetes patients.»

In this study, researchers took cells from patients with blood cancer MDS and turned them into stem cells to study the deletions of human chromosome 7 often associated with this disease.

They found out that TiY is capable of distinguishing TICs from non-TICs in various human lung cancer cell lines and patient - derived lung tumors.

By assessing the survival of the cells that engulf the particles and measuring the levels of red or green light that they emitted, the researchers determined which formulation of particles performed best, then tested that formulation in mice with human brain cancer derived from their patients.

Desgrosellier said the team will follow up with mouse models containing tumor fragments from patients to better reflect the diversity of cell types present in human disease.

Unlike the skin cells from which they originated, the human iPS cells created from FOP patients show increased cartilage formation and increased bone mineralization, two critical steps that are necessary to form mature bone.

Scientists want to be able to clone early human embryos, using cells from patients with various diseases, so they can study the diseases in the lab and develop new treatments for them.

To see if PGD and the pentose phosphate pathway were tied to the epigenetic changes the researchers had detected in distant metastases, they treated tumor cells from different sites in a single patient with the drug 6 - aminonicotinamide (6AN), which is known to inhibit PGD but is not used in humans because of its severe side effects.

After running the simulations at IU Bloomington, Bacallao confirmed the cyst growth predictions seen in the virtual cysts in experiments using real human cells cultivated from polycystic kidneys from patients at the IU School of Medicine.

Now he and his team are putting cells from human brain tumors into the organoids, which have reached the level of development and complexity of a 20 - week - old human fetus's, to see whether they reprise what happens in patients.

«By analyzing mice with the WNT10A mutation, as well as tissues from human patients with WNT10A mutations, we found that WNT10A regulates the proliferation, but not the maintenance, of stem cells in hair follicles,» said Sarah Millar, PhD, vice chair for Basic Research in the Department of Dermatology.

Instead of using these invasive and complicated procedures to obtain cells from hypercholesterolemic patients, Dr Si - Tayeb decided to use a more convenient source of human cells: urine.

The bacterial peptide found to activate MS patients» T cells came from Pseudomonas aeruginosa, a common inhabitant of human skin which can infect wounds.

Strikingly, the researchers noticed the same signs of axonal demise in spinal cord cells obtained from human patients with ALS.

Alternative cell lines, such as induced pluripotent stem cells generated from patient skin cells, offer a more accurate window on human biology, he says.

To test this, the researchers did a side - by - side comparison with cells isolated from elephants (n = 8), healthy humans (n = 10), and from patients with Li - Fraumeni Syndrome (n = 10).

That finding indicates that very low numbers of the cells in the body could be enough to protect human patients from maladies ranging from infections to cancer.

They will study human macrophages and dendritic cells isolated from IBD patients with defective GM - CSF function, «The approach represents a step forward in personalizing how we treat patients with IBD,» said Dr. Colombel.

The researchers, led by University of California, San Diego neuroscientist Mark Tuszynski, took skin cells from the patients, grew them up in a culture dish and genetically engineered them to make human nerve growth factor (NGF).

Karnoub quickly closes the lid and explains that the human cells he tests were removed from patients during surgery or from biopsy specimens.

Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.

In a letter published in the cancer journal Annals of Oncology, researchers led by Professor Jean - Philippe Spano, head of the medical oncology department at Pitie - Salpetriere Hospital AP - HP in Paris, France, report that while treating an HIV - infected lung cancer patient with the cancer drug nivolumab, they observed a «drastic and persistent decrease» in the reservoirs of cells in the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapy.

Although this human Gut Chip recreated the villus epithelium of normal intestine and enabled new insights into how flow and cyclic peristalsis affects intestinal differentiation and function, it could not be used to study processes that relied on normal intestinal cells from individual donors, which, for example, is crucial for studying patient - specific responses for personalized medicine.

One is using cells derived from human embryonic stem cells to treat spinal cord injury (although funding problems have stopped the trial enrolling new patients) and another is testing a treatment for age - related macular degeneration.

In the new work, the researchers added serum from Finnish narcolepsy patients who had received Pandemrix to cells that were engineered to display human hypo cretin receptor 2 on their surface.

To uncover the identities and roles of these channels in humans, Donald Welsh and colleagues from the University of Calgary investigated smooth muscle cells from cerebral arteries harvested from patients undergoing brain surgery.

ACT announced last November that they had cloned early - stage human embryos in a step toward therapeutic cloning (which seeks to treat diseases by using genetic material from a patient's own cells) but the company believes that reproductive cloning is too risky and unwarranted at this time.

After confirming in mouse models that cells from HER2 - positive breast cancers became resistant to anti-HER2 treatment when implanted into the brain but not into other tissues, the investigators found that HER3 is overexpressed in brain metastases of HER2 - positive breast cancers from both mice and human patients.

Palanichamy, Chakravarti and their colleagues conducted this study using 13 primary GBM cell lines derived from patient tumors, four commercially available GBM cell lines and normal human astrocyte cells.

«We used human skin cells that we obtained from patients affected with ALS and converted them into neurons via a technology called induced pluripotent stem cell production,» she explains.

In the new paper, Sahin and colleagues took their observations to humans, studying Purkinje cells derived from three patients with TSC (two also had ASD symptoms, and all three also had epilepsy).

The researchers studied tumour tissue from patients, cultivated human tumour cells and tumours in mouse models for neuroblastoma.

In the first published results from a clinical trial using human embryonic stem cells, two legally blind patients who received an injection of hESC - derived cells in one eye have experienced no harmful side effects and appear to have slightly better vision.

Earlier this year, scientists at University of California, Los Angeles, and Advanced Cell Technology of Marlborough, Massachusetts, reported in The Lancet about the safe and successful use of RPE cells derived from human embryonic stem cells, rather than iPS cells, to treat a different type of AMD in a limited number of human patients.

One team in Japan, and another in the US, have independently shown it is possible to produce embryonic - like stem cells directly from a patient's own skin cells without having to create and destroy a cloned human embryo first.