Gunawardane is particularly interested in what happens as
human cells grow and develop.
Nor do they need to be nourished from underneath by «feeder layers» of animal cells which have been shown to contaminate
human cells grown, making them unsuitable for use in medical treatments.
In experiments in
human cells grown in a lab dish, the researchers showed that they could accurately label mRNA molecules and determine how frequently they are being translated.
Already, researchers have used CRISPR / Cas9 to edit genes in
human cells grown in lab dishes, monkeys (SN: 3/8/14, p. 7), dogs (SN: 11/28/15, p. 16), mice and pigs (SN: 11/14/15, p. 6), yeast, fruit flies, the worm Caenorhabditis elegans, zebrafish, tobacco and rice.
Researchers have previously demonstrated that yeast, fruit fly cells and some types of
human cells grown in lab dishes divvy up proteins unequally.
In a paper published in November, working with MIT graduate student Jungmin Lee and chemistry professor Moungi Bawendi, the researchers showed that they could get quantum dots inside
human cells grown in the lab, without the particles becoming confined in endosomes or clumping together.
For example, researchers have demonstrated that the method can be used to treat muscular dystrophy and glaucoma in mice, render
human cells grown in lab dishes resistant to HIV, and help create food crops and livestock with desirable traits.
Not exact matches
ReInnervate, a start - up in Durham, England, is developing a tiny, three - dimensional plastic scaffolding on which
human cells can be
grown into artificial tissue, and perhaps eventually into replacements for organs.
For example, using 3 - D bioprinters — which can print the structure of
human tissue with biodegradable material — and stem
cells, which are used to populate the 3 - D printed structure, researchers can
grow actually
human tissue.
A research group at Cincinnati Children's Hospital Medical Center used
human pluripotent stem
cells (hPSCs) to
grow human stomach tissue (paywall)-- and, notably, the part of the organ that produces digestive enzymes.
The group also reported — and I guess I'm burying the sci - fi lede here —
growing human cells and tissues in pig and cattle embryos.
And with 7billion on the planet (and
growing), these «young people missing millions from their generation» should be thankful that clusters of
cells can be medically removed, preventing unwanted births and (perhaps) even saving the
human population from
growing to a point of unsustainability.
The lab -
grown meat — which the company calls «clean meat» — is developed from self - reproducing
cells taken from a chicken, with the purpose of creating a product that omnivores can't distinguish from the real thing, but with a fraction of the considerable downsides of meat production, including environmental destruction and using agricultural land to
grow animal feed rather than crops for
human consumption.
Capsaicin additionally produced a significant deceleration of the development of prostate tumors created simply by those
human cell lines
grown in mouse models.
Human milk is a bodily fluid which, apart from being an excellent nutritional source for the
growing infant, also contains a variety of immune components such as antibodies, growth factors, cytokines, antimicrobial compounds, and specific immune
cells [9].
Here moms are, taking two
cells, feeding them, nurturing them, helping them divide and
grow to produce an entirely new
human being.
As well as allowing the use of stem
cells grown from established
cell lines, the technology could enable the creation of improved
human tissue models for drug testing and potentially even purpose - built replacement organs.
In 2011, the team was the first to report functional, lab -
grown anal sphincters bioengineered from
human cells that were implanted in immune - suppressed rodents.
Researchers hope the organoids will be better than lab animals or
cells growing in culture at revealing how the
human brain develops, both normally and when things go awry, and identify potential therapeutic or genome - editing targets.
To make the HSCs, the Harvard group used
human skin
cells to create induced pluripotent stem
cells (iPSCs), adult
cells researchers genetically reprogram to an embryonic - stem -
cell state, where they can
grow into any kind of
cell.
Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory -
grown,
human airway
cells that a condensed form of cigarette smoke triggers so - called «epigenetic» changes in the
cells consistent with the earliest steps toward lung cancer development.
Several of the strains could already
grow in
human cells, Shi's team found.
Introducing
human prostate cancer
cell lines into mice, Wu and his colleagues saw a particular enzyme called MAOA activate a cascade of signals that made it easier for tumor
cells to invade and
grow in bone.
To create the effect of tobacco smoke on
cells, Vaz, Baylin and their colleagues began their studies with
human bronchial
cells, which line the airways of the lungs, and
grew them in a laboratory.
Famous for: Uses stem
cells to
grow human bone - potentially changing how surgeries are performed.
Da Cruz and his team
grew replacement RPE
cells from
human embryonic stem
cells on a thin plastic scaffold, before transplanting the tissue into the back of each volunteer's eye.
If life can
grow out of the formal chemical substrate of the
cell, if consciousness can emerge out of firing neurons, then so too will computers attain
human intelligence.
Two people with severe sight loss can now see well enough to read after receiving tissue
grown from
human embryonic stem
cells.
When Cornell - Bell's team added kainate to astrocytes
grown from
human tissue removed during surgery for epilepsy, the
cells glowed in chaotic patterns.
Working with Skeletal Biologists at Southampton General Hospital, Catarina is investigating new optical techniques to monitor the development of the
cells, used in new regenerative medicine approaches — in this case, to create and
grow cartilage from
human stem
cells.
TWO types of
human ear
cell have been
grown in the lab from fetal stem
cells.
To get more
cells, researchers from Advanced
Cell Technology in Worcester, Mass., grew clusters of human embryonic cells in a precise cocktail of growth factors and other cell - regulating chemicals that took several years to work out, says Robert Lanza, the firm's vice president of research and scientific developm
Cell Technology in Worcester, Mass.,
grew clusters of
human embryonic
cells in a precise cocktail of growth factors and other
cell - regulating chemicals that took several years to work out, says Robert Lanza, the firm's vice president of research and scientific developm
cell - regulating chemicals that took several years to work out, says Robert Lanza, the firm's vice president of research and scientific development.
«Our work illustrates that this exquisite control mechanism — regulated by PUS7 and pseudouridine — is critical to adjusting the amount of proteins needed for
human stem
cells to
grow and produce blood,» says Cristian Bellodi.
The scientists also showed, in lab - cultured
human cells, that an ALDH - blocking drug strips regulatory T -
cells of their ability to
grow and protect themselves from cyclophosphamide.
The only way the team can be sure they have
grown the equivalent of a fetal brain would be to genetically test individual
cells from different regions of the organoid, and compare them to those of
human fetus, says Christof Koch at the Allen Institute for Brain Science in Seattle.
«I'm working with Professor Richard Oreffo and Dr Rahul Tare from the University's Centre for
Human Development, Stem
Cells and Regeneration who are trying to create and grow cartilage in the lab using a patients» own (autologous) stem cells to then be implanted back into the patient if they have a cartilage defect,» she expl
Cells and Regeneration who are trying to create and
grow cartilage in the lab using a patients» own (autologous) stem
cells to then be implanted back into the patient if they have a cartilage defect,» she expl
cells to then be implanted back into the patient if they have a cartilage defect,» she explains.
In August 2006, Lanza and his co-authors published a paper in Nature showing that a single
cell could be plucked from an 8 -10-
cell human embryo and
grown into stem
cells.
Using
human fetal «mini-brains»
grown in 3 - D cultures, scientists determined that a specific protein produced by the Zika virus changes the properties of neural stem
cells in the developing brain of an infected fetus, potentially causing microcephaly in newborns (Ki - Jun Yoon, abstract 103.06, see attached summary).
Growing to just one millimeter in length, these simple creatures have only 302 neurons, or nerve
cells, in their bodies, a tiny fraction of the 80 billion or so neurons in the
human brain.
Stem
cells from breast milk can
grow into many other kinds of
human tissue, raising hopes of an ethical source of embryonic - like stem
cells
Abba Zubair, M.D., Ph.D, believes that
cells grown in the International Space Station (ISS) could help patients recover from a stroke, and that it may even be possible to generate
human tissues and organs in space.
In addition, they injected mice with
human cancer
cells and found that the tumors
grown in mice could be inhibited with PD173074.
The team found that exposing samples of
human glioblastoma tumours
grown in a dish to the Zika virus destroyed the cancer stem
cells.
Although researchers do not yet know the biological significance of these discoveries, they say that fully cataloguing the genome may help them understand how genetic variations affect the risk of contracting diseases such as cancer as well as how
humans grow from a single -
celled embryo into an adult.
Bloch's colleagues at the National Institute of Environmental Health Sciences tested the oils in gene expression studies on lab -
grown human breast cancer
cells and found that they could mimic estrogens, the primary female sex hormones, and inhibit androgens, the primary male sex hormones.
Several studies have supported a role for cancer stem
cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing
human tumors to
grow in mice, and as such their relevance to cancer in
humans has been questioned.
«Researcher to
grow human cells in space to test treatment for stroke.»
Components of indoor dust may signal
human fat
cells to
grow and may alter metabolism, potentially contributing to weight problems, researchers report July 14 in Environmental Science & Technology.
Wells's team first turned
human skin
cells into pluripotent stem
cells, which can
grow into any type of tissue.
The same observations were made in organoids (artificially
grown masses of
cells that resemble an organ) created from unique basal progenitor
cells that were isolated from the gastroesophageal junction in mice and
humans.