Sentences with phrase «human cells in culture»

«Among other things, the NAS Report calls for the Environmental Protection Agency to implement a toxicity testing strategy that is based on non-mammalian systems and human cells in culture [in vitro],» Rene explains.

«Compared to traditional methods that have allowed us to investigate human cells in culture in two - dimensions, these cultures let us investigate the three - dimensional structure and function of the cells as they are developing, giving us more information than we would get with a traditional cell culture.»

Rudolph Tanzi and Robert Moir, who study neurodegeneration at Harvard MGH, sought to test whether amyloid - β might protect mice, Caenorhabditis elegans nematodes, and human cells in culture from invasion by various microbes.

Investigations into human brain development using human cells in the culture dish have so far been very limited: the cells in the dish grow flat, so they do not display any three - dimensional structure.

Testing the effectiveness of this molecule in their VLP assay, they found that it reduced the ability of the virus to bud off from human cells in culture by more than 90 percent and was similarly effective against proteins found in Ebola and HIV.

Greber and his team infected human cells in culture with the chemically labeled viruses, and observed the behavior of the viral DNA during entry into cells.

One week, the pair went to a conference to present a poster on the aging of human cells in culture.

Not exact matches

In both cases individual members may exercise some dominance over others, in particular by altering the patterns guiding further growth and development, but the social coordination stems from basic patterns embodied in the genetic makeup of the plant cells and in the laws and traditions of human culturIn both cases individual members may exercise some dominance over others, in particular by altering the patterns guiding further growth and development, but the social coordination stems from basic patterns embodied in the genetic makeup of the plant cells and in the laws and traditions of human culturin particular by altering the patterns guiding further growth and development, but the social coordination stems from basic patterns embodied in the genetic makeup of the plant cells and in the laws and traditions of human culturin the genetic makeup of the plant cells and in the laws and traditions of human culturin the laws and traditions of human culture.

The researchers experimented with inducing oxidative stress in a human cell line culture with and without VCOP (virgin coconut oil polyphenols) to observe how VCOP positively promoted catalase, a very important enzyme in protecting the cell from oxidative damage, and glutathione (GSH), a self - recycling antioxidant produced by the liver.

In both plant and human cell cultures coconut water extends the youth of the cells.

Transient Silencing of 14 -3-3sigma promotes proliferation of p63 - positive progenitor cells isolated from human breastmilk in mammary epithelial cell culture.

Visually, she is filming and analyzing time - lapse images of human embryos in the incubator and has been able to correlate various parameters of how cells divide with the probability that the embryos will make it to a full blastocyst stage by day 5 - 6 of culture.

While scientists have previously had success in 3D printing a range of human stem cell cultures developed from bone marrow or skin cells, a team from Scotland's Heriot - Watt University claims to be the first to print the more delicate, yet more flexible, human embryonic stem cells (hESCs).

Researchers hope the organoids will be better than lab animals or cells growing in culture at revealing how the human brain develops, both normally and when things go awry, and identify potential therapeutic or genome - editing targets.

While other papers have examined these mutations using expensive and time - consuming experiments on live ferrets and laboratory cell cultures, Deem and Melia Bonomo used the pEpitope method to rapidly calculate how much the egg - passage mutations would decrease vaccine efficacy in humans.

In November 2010 Japanese researchers announced online in Analytical Chemistry that they had built a chip that simultaneously tests how liver, intestine and breast cancer cells respond to cancer drugs, and in February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cellIn November 2010 Japanese researchers announced online in Analytical Chemistry that they had built a chip that simultaneously tests how liver, intestine and breast cancer cells respond to cancer drugs, and in February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cellin Analytical Chemistry that they had built a chip that simultaneously tests how liver, intestine and breast cancer cells respond to cancer drugs, and in February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cellin February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cellin the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cellin cultured cells.

Shukla and colleagues discovered that a small drug molecule called BX795, which is sold to labs for use in experiments, helped clear HSV - 1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV - 1.

Scientists are forced either to experiment on whole animals, which is expensive, raises ethical issues and may not predict effects in humans, or to perform tests on microscopic human cells found in tissue cultures, which have been altered to live forever and bear little relation to actual living, breathing people.

Adding ascorbic acid to culture medium could help overcome the main roadblock in reprogramming human, mouse cells into iPS cells

The scientists also showed, in lab - cultured human cells, that an ALDH - blocking drug strips regulatory T - cells of their ability to grow and protect themselves from cyclophosphamide.

Using human fetal «mini-brains» grown in 3 - D cultures, scientists determined that a specific protein produced by the Zika virus changes the properties of neural stem cells in the developing brain of an infected fetus, potentially causing microcephaly in newborns (Ki - Jun Yoon, abstract 103.06, see attached summary).

To see which are involved in heart - cell division, Giacca's team tested 875 human microRNAs in cultured rodent heart muscle.

A few drugs have shown promise in cell culture or animal models, but clinical trials in humans are time consuming because of the slow onset and progression of the disorder's clinical symptoms.

In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cellIn a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cellin cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cellin differentiated tumor cells.

By analyzing chemical changes of the IRS - 2 protein in immortalized cultures of human white blood cells, it determined that IRS - 2 appeared in two different forms — «on,» which allows the signal to pass through, and «off,» which stops the signal from activating the cells into M2 macrophages.

Pseudomonas also will kill human lung cells in tissue culture dishes.

Oncologists William Hahn, Robert Weinberg, and colleagues at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, mutated the gene for one part of the enzyme and inserted it into cultured human cells from colon, ovary, and breast tumors.

The mutated, drug resistant H7N9 virus, however, was still able to infect cultured human cells and spread between laboratory animals as efficiently as nonmutated strains, researchers report December 10 in Nature Communications.

Human nasal epithelial cells, cultured on a microchip, react to air pollutants just like they would in the upper airway.

In rats and tissue cultures of human nerve cells, these «beta sheet breakers» not only prevent amyloid plaques from forming, but also dissolve existing plaques.

The team used human embryonic stem cells — which can transform into any cell of the body — and cultured them in a mixture of chemicals to grow human brain cells.

Follow - up tests in human cell cultures confirmed that MIR168a interferes with production of a cholesterol - clearing protein.

In studies with human fibroblasts that make up connective tissue, Boger's team tested whether NOD1 activity could affect CMV replication in cultures of cells grown in the laIn studies with human fibroblasts that make up connective tissue, Boger's team tested whether NOD1 activity could affect CMV replication in cultures of cells grown in the lain cultures of cells grown in the lain the lab.

To test their hypothesis, the researchers harvested dermal papillae from seven human donors and cloned the cells in tissue culture; no additional growth factors were added to the cultures.

This was observed in human ovarian cancer cells grown in culture, and then in mouse models of the disease.

A human brain cell culture grown in vitro has spontaneously transformed, as determined by morphology, growth characteristics, and karyotype analysis.

In a previous related study published in the Journal of Materials Science: Materials in Medicine, the same team of NTU scientists found that fish scale - derived collagen would induce human umbilical vein endothelial cells to express 2.5 times more of a specific type of collagen responsible for blood vessel formation, as compared to endothelial cells cultured on bovine collageIn a previous related study published in the Journal of Materials Science: Materials in Medicine, the same team of NTU scientists found that fish scale - derived collagen would induce human umbilical vein endothelial cells to express 2.5 times more of a specific type of collagen responsible for blood vessel formation, as compared to endothelial cells cultured on bovine collagein the Journal of Materials Science: Materials in Medicine, the same team of NTU scientists found that fish scale - derived collagen would induce human umbilical vein endothelial cells to express 2.5 times more of a specific type of collagen responsible for blood vessel formation, as compared to endothelial cells cultured on bovine collagein Medicine, the same team of NTU scientists found that fish scale - derived collagen would induce human umbilical vein endothelial cells to express 2.5 times more of a specific type of collagen responsible for blood vessel formation, as compared to endothelial cells cultured on bovine collagen.

Through these effects, the PERY peptide reduced the proliferation of several (but not all) cancer cell lines in culture and inhibited the growth of a human breast cancer xenograft in mice.

To date, the researchers have tested the function of their activation - ready sensor in cell culture of human kidney and cancer cells.

The successful growth of human skin cells in culture has made it possible to restore epidermis after severe burns and other forms of damage

Though Li's adhesive has been tested only in human cell cultures and in lab animals, another bio-inspired glue has made its way into human trials.

You can look for efficacy in cell cultures, but that tells you almost nothing about what's going to happen when you test in a mouse or a human.

They noticed that while the dermal papilla cells from mice naturally formed large clumps in culture, the human cells didn't.

They found that indeed, they do, and that stimulating these cells led them to kill cells infected with HIV - 1 derived from latently infected cells, both in culture and in mice engineered to have a human immune system.

Studies of IBD are typically performed using cell culture experiments or animal models, which don't mimic the precise conditions that occur in the gut of human patients.

The Mount Sinai study found that harmine drove the sustained division and multiplication of adult human beta cells in culture, a feat that had eluded the field for years.

«We compared the ability of RSV and parainfluenza virus (PIV3)-- another common virus in children that causes much less severe airway disease — to infect and cause inflammatory responses in a cell culture model of human epithelial cells, which compose the lining of the lung airway.

protected animals»); studies on in vitro systems (whole perfused organs, tissue slices, cell and tissue cultures, and subcellular fractions); and human studies (including estimations of occupational and environmental exposure, postmarketing surveillance, epidemiology, and the ethical and strictly controlled use of human volunteers).

Although electrolyte leakage is still undesired, its danger is minimized by the use of either the normal saline solution pumped into the body in most IV treatments or a cell - culture medium that contains amino acids, sugars, and vitamins in addition to sodium ions and thus mimics the fluid that surrounds human cells.

The test procedure is performed on an in vitro skin model built at Fraunhofer IGB from human skin cells in special culture dishes.