Sentences with phrase «human cells resistant»

Not exact matches

«We've been targeting human cells with therapeutics that modulate the way the cell makes lipids, and we like to target the human cell because it isn't likely to mutate and become resistant to the drug.

Shih, Wang and their colleagues tested fostamatinib's power to reduce tumor size in mice implanted with human ovarian cancer cells that were resistant to paclitaxel.

While testing the effect of many normal, non-cancerous, human cells on the sensitivity of cancer cells to chemotherapy, they found a specific sample of normal human skin cells that rendered pancreatic cancer cells resistant to gemcitabine.

Serendipitously, the antimicrobial peptide shows promise for protecting humans from cancer; it can inhibit the growth of prostate and bladder cancer cells, as well as multi-drug resistant leukemic cells.

The mutated, drug resistant H7N9 virus, however, was still able to infect cultured human cells and spread between laboratory animals as efficiently as nonmutated strains, researchers report December 10 in Nature Communications.

The researchers showed that cabazitaxel worked better than docetaxel in human prostate cancer cells lines that were resistant hormone treatment, both in terms of slowing cancer - cell growth and in its ability to kill cancer cells.

In addition to the afatinib - resistant NSCLC cells, the researchers tested the neratinib and valproic acid combination on cell lines derived from human pancreatic and ovarian cancers containing K - Ras mutations and N - Ras mutations, respectively.

Some humans naturally carry this mutation (known as CCR5Δ32) and they are resistant to HIV, because the mutation alters the CCR5 protein in a way that prevents the virus from entering the T cells it tries to infect.

Researchers in China have edited the genes of human embryos to make cells resistant to HIV infection.

The results of this original study are highly relevant to other human diseases that dependent on genome instability, such as fungal infection or cancer, and open new venues for anti-leishmanial drug discovery using host - directed strategies that target the parasite's metabolic dependence on the host cell, thus preventing the adaptive evolution of drug resistant parasites.

After confirming in mouse models that cells from HER2 - positive breast cancers became resistant to anti-HER2 treatment when implanted into the brain but not into other tissues, the investigators found that HER3 is overexpressed in brain metastases of HER2 - positive breast cancers from both mice and human patients.

In this study we describe the design and pre-clinical evaluation of a CXCR4 - specific ZFN pair (X4 - ZFNs) that specifically and efficiently disrupts cxcr4, rendering human CD4 + T cells permanently resistant to HIV - 1 strains that require CXCR4 for infection.

Citation: Wilen CB, Wang J, Tilton JC, Miller JC, Kim KA, Rebar EJ, et al. (2011) Engineering HIV - Resistant Human CD4 + T Cells with CXCR4 - Specific Zinc - Finger Nucleases.

Similar to the results obtained with cultured human cells, the transgenic mice were resistant to avian influenza viruses but susceptible to flu viruses of human origin.

Our studies provide a fundamental demonstration that inactivation of cxcr4 by treatment with X4 - ZFNs rendered human CD4 + T cells resistant to infection by X4 virus strains, while CXCR4 inactivation in the context of a ccr5Δ32 homozygous background rendered cells resistant to infection by both R5 and R5X4 strains.

SAN FRANCISCO, CA — Researchers at the Gladstone Institutes and UC San Francisco (UCSF) have used a newly developed gene - editing system to find gene mutations that make human immune cells resistant to HIV infection.

Researchers at the Gladstone Institutes and UC San Francisco (UCSF) have used a newly developed gene - editing system to find gene mutations that make human immune cells resistant to HIV infection.

Furthermore, expression of a degradation - resistant RAPGEF2 mutant greatly suppresses dissemination and metastasis of human breast cancer cells.

They then examined the effect of a chemical that inhibits SRF and found that glucose uptake rates increased in both mice and human cells — and that the effects were greater in cells from patients who were insulin resistant or had type 2 diabetes.

Shiga toxins induce autophagy leading to differential signalling pathways in toxin - sensitive and toxin - resistant human cells.

For example, researchers have demonstrated that the method can be used to treat muscular dystrophy and glaucoma in mice, render human cells grown in lab dishes resistant to HIV, and help create food crops and livestock with desirable traits.

The TNF family molecules LIGHT and lymphotoxin ab induce a distinct steroid - resistant inflammatory phenotype in human lung epithelial cells.

In the resistant infections, the communication system used by MRSA bacteria to «talk» among each other is silenced, and with it the ability to release toxins that damage human cells.

In another study, 11 human cancer cell lines (carcinomas and glioblastomas) were exposed to ascorbic acid in which 55 % of the cell lines were more susceptible (EC50 ≤ 20 mmol / L) and 45 % were more resistant (EC50 > 20 mmol / L) to incubation.

If you missed it, I posted a short but very nice Primer on Resistant Starch yesterday, which I highly suggest you read as a prerequisite so that you're generally familiar with the critical importance of this in the realm of general health for the 100 % of you, and not just the 10 % of you that are your human cells.

(Type 2 is found more commonly in adult humans and cats, generally arises from obesity, and occurs when the cells of the body become resistant to normal amounts of insulin, as opposed to a lack of insulin production.)