A series of fine - tuned maps of DNA packaging in
human cells reveal dynamic new views of how the genome's instructions are carried out to build a person.
Proteomic analysis of arginine methylation sites in
human cells reveals dynamic regulation during transcriptional arrest.
Not exact matches
This approach
revealed a highly sensitive portrait of the genes being expressed in
human milk - making
cells.
Researchers hope the organoids will be better than lab animals or
cells growing in culture at
revealing how the
human brain develops, both normally and when things go awry, and identify potential therapeutic or genome - editing targets.
The analysis
revealed that the
human genome is organized into large pieces of low or high epigenetic stochasticity, and that these regions correspond to areas of chromosomes that are structurally different in the
cell nucleus.
An analysis of the HPV16 genome from 5,570
human cell and tissue samples
revealed that the virus actually consists of thousands of unique genomes, such that infected women living in the same region often have different HPV16 sequences and variable risks to cancer.
BRAIN CANDY A new database offers a deep look at living
human nerve
cells,
revealing elaborate branching structures and myriad shapes, such as in this neuron called a pyramidal
cell (
cell image, left and 3 - D computer reconstruction, right).
A study published by
Cell Press October 16th in
Cell now
reveals that gut microbes in mice and
humans have circadian rhythms that are controlled by the biological clock of the host in which they reside.
Genetically reprogramming late - stage
human cancer
cells to a stem -
cell state enabled them to force the reprogrammed
cells to progress to an early cancerous state,
revealing secreted blood biomarkers of early - stage disease along the way.
Now, scientists from the Perelman School of Medicine at the University of Pennsylvania
reveal that the release of AMPs is partially controlled by bitter taste receptors in the upper airway on a
cell previously identified in animals and only recently in
humans known as solitary chemosensory
cells (SCCs).
Additionally, work in a mouse model
revealed similar
cells, indicating that the progenitors are conserved from mouse to
human, and therefore, they must be «important
cells with promising potential for
cell therapy in treating liver disease,» explained Dr. Gouon - Evans.
The discovery may help
reveal how
humans and other animals evolved from single -
celled organisms over the last 600 million years.
Two new studies
reveal that administering a potent, broadly neutralizing antibody that binds to HIV evokes a strong immune response in
humans, and can even accelerate the clearance of infected
cells.
Cell biologists and chemists from the University of Zurich
reveal how viral DNA traffics in
human cells.
ALMOST BRAIN A cross section of an immature lab - grown approximation of a
human brain
reveals neurons (green) and neuron - producing stem
cells (red).
The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple
human cancer
cell lines to different chemotherapy agents based on the
cell lines» genetic profiles and also
revealed new genetic factors that appear to determine the response of breast and ovarian tumor
cells to common classes of chemotherapy treatment.
The scientists used the new indexing method on several
human cell lines and from a mouse brain to
reveal the methylome of 3,282 single
cells.
Experiments conducted in mice and in
human ALS
cells reveal that when RIPK1 is out of control, it can spark axonal damage by setting off a chemical chain reaction that culminates in stripping the protective myelin off of axons and triggering axonal degeneration — the hallmark of ALS.
«Infected Tasmanian devils
reveal how cancer
cells evolve in response to
humans.»
During the last several years, research efforts with
human cell lines
revealed that the genomic loci encoding tRNAs give rise to shorter tRNA fragments («tRFs»).
Cranberries also contain a number of compounds that benefit
human health — including some that have been shown to inhibit the growth of tumor
cells — and sequencing work may
reveal more about them.
The study of HCMV is
revealing new ways in which
human cells function, highlighting the role of proteins and other factors that have never been described in these ways before.
A study of the way malaria parasites behave when they live in
human red blood
cells has
revealed that they can rapidly change the proteins on the surface of their host
cells during the course of a single infection in order to hide from the immune system.
Because hers were the first
human cells cultured continuously for use in research, Lacks» identity was
revealed in a scientific journal in 1971 in reference to the landmark accomplishment.
Because you can't sedate
humans and attach radio collars, scientists are studying
human movements with
cell phone records that
reveal locations.
In work published in The EMBO Journal, the researchers
reveal that the delivery of mitochondria to
human lung
cells can rejuvenate damaged
cells.
If its claims hold, and future research
reveals how crayfish blood
cells are reprogrammed to become neurons, it could offer new therapeutic ways of doing the same with
human cells.
Specifically, the study
revealed parallels to autism in
humans at the levels of brain
cells, networks, and behavior, said study senior author Carlos Aizenman, associate professor of neuroscience at Brown.
The new Mount Sinai study
reveals how loss of a protein called Sirtuin1 (SIRT1) affects the ability of blood stem
cells to regenerate normally, at least in mouse models of
human disease.
The research, «Synchrotron X-Ray Fluorescence Nanoprobe
Reveals Target Sites for Organo - Osmium Complex in
Human Ovarian Cancer
Cells», is published in Chemistry — A European Journal.
The findings, published this week in mBio ®, an open - access journal of the American Society for Microbiology, highlight new ways by which viruses manipulate
human cells and may
reveal new targets for designing antiviral therapies.
«Massive single -
cell survey of kidney
cell types
reveals new paths to disease: Study of over 57,000
cells from mouse kidneys help identify
human renal disorders.»
A new cellular reprogramming method has been
revealed that transforms
human skin
cells into liver
cells that are virtually indistinguishable from the
cells that make up native liver tissue.
The result — the first complete structure of a virus in the flavivirus family —
reveals a layered, soccer - ball - like shape lacking the spiky projections characteristic of many
human viruses, the researchers report in the 8 March issue of
Cell.
Further experiments in
human brain
cells called astrocytes, which are targeted by CMV,
revealed a 100-fold decrease in the amount of virus present when they were treated with valnoctamide (Journal of Neuroscience, DOI: 10.1523 / jneurosci.0970 - 17.2017).
Targeting the labeled
cells for analysis, they
revealed that their organoids contained a population of sensory
cells that have the same functional signature as
cells that detect gravity and motion in the
human inner ear.
Now, University of Pennsylvania researchers have
revealed how a reduction in mitochondrial DNA content leads
human breast cancer
cells to take on aggressive, metastatic properties.
«Induced pluripotent stem
cells reveal differences between
humans and great apes.»
Writing in the latest issue of the journal Nature, researchers in the laboratories of Gladstone Senior Investigator Sheng Ding, PhD, and UCSF Associate Professor Holger Willenbring, MD, PhD,
reveal a new cellular reprogramming method that transforms
human skin
cells into liver
cells that are virtually indistinguishable from the
cells that make up native liver tissue.
Scientists are champing at the bit to find out what President George W. Bush's newly
revealed policy will really mean for research using
human embryonic stem
cells.
Studies in the last two decades
revealed that telomeres and telomerase have dual functions in suppressing and facilitating tumorigenesis: In the adult
human, the activity of telomerase is mostly restricted to the stem
cells and is absent from the vast majority of
human cells.
Analysis of the trajectories of people carrying
cell phones
reveals that
human mobility patterns are highly predictable.
Furthermore, this study
revealed that
cells derived from
humans can be grafted into the heterozygous inner ear of mouse embryos.
As Mani Subramanian, Summers's adviser, points out, 90 % of the
cells in our body are bacterial, and research into the
human microbiome, our total complement of bacteria, has
revealed that we are veritable rainforests when it comes to bacterial diversity.
Use of the immunofluorescent microscopy visualization technique
reveals the presence of specific proteins in naive
human embryonic stem
cells.
A special class of brain
cells reflects the outside world,
revealing a new avenue for
human understanding, connecting and learning
«Our data
reveals, in exquisite resolution, that the conversation between
cells of different types changes the
cells in a way that likely mimics what is going on during
human development,» said Treutlein at Max Planck.
The technique, carried out in living
human cells and fruit flies, should help
reveal how irregularities in protein synthesis contribute to developmental abnormalities and
human disease processes including those involved in Alzheimer's disease and other memory - related disorders.
Immunohistochemical staining of rejected
human corneal allografts has
revealed the presence of apoptosis in corneal stromal
cells (5).
The example shown
reveals that these estrogen agonists show the strongest connectivity to each other in MCF7, a
human breast cancer
cell line that expresses the estrogen receptor.