Sentences with phrase «human cellular models of»

The project will analyse the chemical changes that occur in Unkempt in human cellular models of TSC.

Not exact matches

The disruption of prenatal cellular activity in zebra fish, which share 80 percent of their genes with humans and are considered a good model for studying human brain development, seemed to result in hyperactivity, according to the Canadian study, which was published Monday in the Proceedings of the National Academy of Sciences.

The scientists are testing the ability of drugs already on the market to reverse this cellular transformation in the pancreas in mice models of human pancreatic cancer.

Now, in this week's issue of the Proceedings of the National Academy of Sciences, Thomas Albright and Ricardo Gil - da - Costa of the Salk Institute for Biological Studies describe a model system that completes the bridge between cellular and human studies of schizophrenia, an advance that should help speed the development of therapeutics for schizophrenia and other neurological disorders.

While scientists could do cellular work in animal models on the role of dopamine versus glutamate, and they could do EEGs in human beings, a bridge between the two remained elusive.

To do this, they created a cellular model of Werner syndrome by using a cutting - edge gene - editing technology to delete WRN gene in human stem cells.

For instance, CiRA's Kohei Yamamizu recently reported developing a cellular model of the blood — brain barrier made entirely from human iPS cells.

Interestingly, when compared to human cellular models, mouse models of PD did not demonstrate the same toxic cascade, according to the study.

With CiPA, human iPSC - cardiomyocytes are employed to assess drug effects on the cardiac action potential to confirm the outcome of in silico modeling efforts, relying on hiPSC - cardiomyocytes to provide the integrated drug response from multiple native human currents in a human - derived cellular preparation.

The researchers hope their new cell lines will be a useful resource for studying the cellular and molecular intricacies of Huntington's further, and suggest they may provide a model for examining other diseases of the brain that are specific to humans.

Drosophila serves as a model organism that helps geneticists to decode the molecular fundamentals of cellular biology and unravel mechanisms that are conserved in human beings and other vertebrates.

It's now possible to not only model disease using the cells, but also to compare iPSCs from humans to those of our closest living relatives --- great apes, with which we share a majority of genes --- for insight into what molecular and cellular features make us human.

Dr. Maria Iribarne, first author of this study, commented: «The gosh mutant is a good model for understanding the molecular and cellular mechanism of cone cell death and the pathological process of human LCA.

«The development of this microfluidic lung model, as well as other organs - on - chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

Dr. Chartoff's Neurobiology of Motivated Behavior Laboratory, founded in 2009, investigates the molecular, biochemical, and cellular mechanisms underlying drug dependence and withdrawal using animal behavioral models with high relevance to the human condition.

One challenge has been the lack of animal and cellular models that can precisely replicate the human disease for scientific investigation.

Human Embryonic Stem (hES) cells derived from Preimplantation Genetic Diagnosed (PGD)- embryos offer a new alternative source of cellular model as they can be largely expanded, differentiated in several cell types and harbors «naturally» the causative mutation of the pathology.

Molecular mechanism underlying diseases (conformational diseases, cystic kidney disorders, neuromuscular diseases, inflammation, iron - related diseases, disorders of human reproduction, osteoporosis and bone diseases) are being investigated by many groups with robust animal and cellular models and patients» biological samples.

Monogenic diseases are often lacking of physiological human cellular models dedicated to the study of the molecular mechanism implicated in the development of the pathology.

We investigate cellular and molecular mechanisms of retinal degeneration and regeneration using rodents and human cells as model systems.

We address these fundamental biological questions at the organismal level, utilizing relevant models of human cancer, and at a cellular and detailed molecular structural level.

Here researchers were able to work with a human cellular model genetically identical to that of the patients.

Sergiu P. Pasca, 36, assistant professor of psychiatry and behavioral sciences at Stanford, uses models of the human brain — created through cellular reprogramming technology — to explore the biological underpinnings of brain diseases like autism.

He has developed novel cellular models of neurological diseases (schizophrenia, MS, autism, Alzheimer's, Parkinson's) using human induced pluripotent stem cells (iPSCs) derived from donor patients and differentiated to specific neuronal cell types.

The Alliance brings together the efforts of the major National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)- funded Model Organism Database (MOD) groups, and the Gene Ontology (GO) Consortium, in a synergistic integration of expertly - curated information about the functioning of cellular systems.

Telomere length predicts both cellular health and disease in rodent models and humans.8 Shorter telomeres predict onset of cardiometabolic diseases of aging.9 Chronic stress is associated with higher inflammation, shorter telomeres, and lower activity levels of telomerase, the cellular enzyme that elongates telomeric DNA.10, 11 Levels of amyloid beta (Aβ) proteins circulating in the blood appear to be stress - related in rodent models12 and may be affected by stress reduction, and greater Aβ42 / Aβ40 ratios are associated with lower risk of dementia.13

She continued to develop these models and to investigate the molecular and cellular mechanisms underlying human tumor dormancy as an instructor in Folkman's lab and later as an Assistant Professor at the Center of Cancer Systems Biology at Tufts University School of Medicine, Boston.

«We haven't had human cellular models that faithfully reproduce this feature of the disease,» said Gottesfeld.

Design and Methods Taking advantage of a model of spontaneous cellular transformation, we sequenced JAK1 in selected tumorigenic BaF3 clones and identified 25 de novo JAK1 activating mutations, including 5 mutations already described in human leukemias.

The advent of human - induced pluripotent stem cell (hiPSC) technology has provided a unique opportunity to establish cellular models of disease from individual patients, and to study the effects of the underlying genetic aberrations upon multiple different cell types, many of which would not normally be accessible.

These findings have identified an alternative source of replacement tissue for use in human retinal cellular therapies, and provide a new in vitro cellular model system in which to study RPE diseases affecting human patients.

Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential to provide improved cellular models of human disease.

The authors of the study explain that their findings suggest that ketogenic diets could also potentially help normalize pathological behaviors in the human model of schizophrenia by providing alternative energy sources via ketones, the products of fat breakdown, which would substitute the abnormally functioning cellular energy pathways in the brains of people suffering from this disease.

Bottom line While research has shown some benefits with regards to ER + breast cancer cell death and prevention of metastases within mice and cellular models, it is recommended that human intake should be through diet only, not supplementation.