Sentences with phrase «human cellular responses»
Bethesda, Md., Thurs., Sept. 11, 2014 - Building on a successful three - year pilot project, the National Institutes of Health has awarded more than $ 64 million to six research institutions to create a database of human cellular responses, the Library of Integrated Network - based Cellular Signatures (LINCS).
https://www.genome.gov/ Not exact matches
Working with human immune cells in the laboratory, Johns Hopkins researchers report they have identified a critical cellular «off» switch for the inflammatory immune response that contributes to lung - constricting asthma attacks.
With CiPA, human iPSC - cardiomyocytes are employed to assess drug effects on the cardiac action potential to confirm the outcome of in silico modeling efforts, relying on hiPSC - cardiomyocytes to provide the integrated drug response from multiple native human currents in a human - derived cellular preparation.
«Following on the work of TSRI Professor Ardem Patapoutian, who has identified many of the genes that endow these neurons with selective responses to temperature, pain and pressure, we have found a way to produce induced sensory neurons from humans where these genes can be expressed in their «normal» cellular environment,» said Associate Professor Kristin K. Baldwin, an investigator in TSRI's Dorris Neuroscience Center.
In NHPs specifically also BCG will be evaluated as a gold standard and benchmark vaccine inducing cellular responses for comparison to human data.
G protein - coupled receptors (GPCRs) are actually a huge protein family (i.e., superfamily) of transmembrane receptors that sense molecules outside Eukaryotic Cells in species ranging from yeast to humans, and activate very basic biological pathways and cellular responses inside the cells.
Important features of XMRV biology include (1) tropism for a variety of cell lines, including prostate cancer DU145 and LNCaP cells [27], [43], [48], and human neural cell types [57], (2) adaptations that promote growth in prostate epithelium and human - derived prostate cancer cell lines including an androgen response element in the promoter region [58] and downregulation of APOBEC3G [59], and (3) cellular effects with potential oncogenic properties including increased tumor aggressiveness mediated by downregulation of p27 [60] and differential regulation of several microRNAs [61].