Sentences with phrase «human cellular studies»

Not exact matches

The disruption of prenatal cellular activity in zebra fish, which share 80 percent of their genes with humans and are considered a good model for studying human brain development, seemed to result in hyperactivity, according to the Canadian study, which was published Monday in the Proceedings of the National Academy of Sciences.

«Finding these similarities and studying the aspects of mouse biology that may reflect human biology, allows us to approach the study of human illnesses in a better way,» affirms Bing Ren, one of the principal authors from the ENCODE Consortium and a lecturer in molecular and cellular medicine at the University of California — San Diego.

Now, in this week's issue of the Proceedings of the National Academy of Sciences, Thomas Albright and Ricardo Gil - da - Costa of the Salk Institute for Biological Studies describe a model system that completes the bridge between cellular and human studies of schizophrenia, an advance that should help speed the development of therapeutics for schizophrenia and other neurological disStudies describe a model system that completes the bridge between cellular and human studies of schizophrenia, an advance that should help speed the development of therapeutics for schizophrenia and other neurological disstudies of schizophrenia, an advance that should help speed the development of therapeutics for schizophrenia and other neurological disorders.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

The NRC panel, chaired by neurobiologist Charles Stevens of the Salk Institute in La Jolla, California, looked at more than 500 human, animal, and cellular studies on EMFs and found «no conclusive and consistent evidence... that exposures to residential electric and magnetic fields produce cancer, adverse neurobehavioral effects, or reproductive and developmental effects.

Interestingly, when compared to human cellular models, mouse models of PD did not demonstrate the same toxic cascade, according to the study.

White is interested in human behavior, but said humans are difficult to study at the cellular and synaptic level.

A new study, however, provides insights on the cellular mechanisms that might be targeted to help certain stem cells - called human mesenchymal stem cells (hMSCs)- maintain properties needed to make them clinically useful.

The researchers hope their new cell lines will be a useful resource for studying the cellular and molecular intricacies of Huntington's further, and suggest they may provide a model for examining other diseases of the brain that are specific to humans.

The budding yeast, Saccharomyces cerevisiae, is a prime organism for studying fundamental cellular processes, with the functions of many proteins important in the cell cycle and signaling networks found in human biology having first been discovered in yeast.

That is when studies finally convinced scientists that the minuscule RNA snippets they had taken to calling «microRNA» were regulating cellular and genetic processes throughout the human body and were critical factors in the determination of health and disease.

«This is the first systematic comparison of the mouse and human at the genomic level,» said Bing Ren, Ph.D., co-senior author on the Consortium's main Nature study and professor of cellular and molecular medicine at the University of California, San Diego.

Thanks to our new tools for studying human muscle cellular clocks in vitro, we now have the possibility to investigate this hypothesis in our next study.»

«We believe it is the first example illustrating the process of a developing human heart chamber in vitro,» said Kevin Healy, a UC Berkeley professor of bioengineering, who is co-senior author of the study with Dr. Bruce Conklin, a senior investigator at the Gladstone Institute of Cardiovascular Disease and a professor of medical genetics and cellular and molecular pharmacology at UC San Francisco.

The study is the first, say its authors, to provide evidence that adenosine, a biochemical at the heart of human cellular function, plays another crucial role — keeping on hand a steady number of healthy chondrocytes, the cells that make and sustain cartilage.

«Liver cancer is on the rise worldwide, and in human studies we've now seen that patients can progress from fatty liver disease to liver cancer without any middle steps such as cirrhosis,» says David Moore, a professor of molecular and cellular biology, who led the study with Associate Professor Loning Fu, both at Baylor.

Dr. Maria Iribarne, first author of this study, commented: «The gosh mutant is a good model for understanding the molecular and cellular mechanism of cone cell death and the pathological process of human LCA.

The new cellular and molecular data uncovered in the current study will be «exploited in the future to further improve liver bud organoids» and «precisely recapitulate differentiation of all cell types» in fetal human development, the authors write.

In this study, we investigated the phosphorylation events in human chondrosarcoma cells during cellular stretching.

During those years, the way we study fundamental biological processes underwent a major shift that has now culminated in sequenced human genomes, knowledge of many cellular processes, and a clear path to unraveling roles for individual molecules.

Molecular, subcellular and cellular studies in whole animals or humans; and novel molecular, immunological or biophysical studies of hormone action are also featured.

Dr. Sonntag studies this concept on the molecular and cellular level using a translational research approach that integrates the analysis of human material, such as postmortem brains, primary cell systems, and neural cell populations generated from patients» - or healthy individuals» - derived induced pluripotent stem cells (iPSC), or induced neurons (iNs), in combination with molecular, biochemistry, and lentivirus - mediated gene - engineering technologies.

The Human Biochemical Genetics Section studies selected biochemical defects and other genetic disorders to provide insight into cellular mechanisms and to care for neglected groups of rare disease patients.

Monogenic diseases are often lacking of physiological human cellular models dedicated to the study of the molecular mechanism implicated in the development of the pathology.

The unit study macromolecules that are central in basic processes of cellular life, as well as for specific human pathologies.

«We believe it is the first example illustrating the process of a developing human heart chamber in vitro,» said Kevin Healy, PhD, a UC Berkeley professor of bioengineering, who is co-senior author of the study with Bruce Conklin, MD, a senior investigator at the Gladstone Institute of Cardiovascular Disease and a professor of medical genetics and cellular and molecular pharmacology at UC San Francisco.

In studying the human placenta, researchers looked at gene expression: the process by which a gene's DNA sequence is converted into cellular proteins.

Again, then, there is significant evidence consistent with a role of cellular senescence in age - related lipodystrophy and lipoatrophy, and for the benefits observed in treated mice in these studies to translate into aging humans.

One new way that scientists study this process of cellular development — and a way in which they hope to grow replacement tissue for medical treatments in the future — is by recreating the essential features of human brains, eyes, lungs, and guts in a petri dish.

The ability to obtain neurons directly and non-invasively from human individuals of different age groups will offer opportunities to study intrinsic cellular properties... >> MORE

The Environmental Influences on Health and Disease Group at Sanford Research studies how environmental factors influence cellular function and human disease, an important interface between chemistry, molecular and cell biology, and physiology.

For this reason, the in vivo studies on the human metabolism must be flanked by in vitro and ex-vivo analyses on organ physiology and cellular mechanisms.

The advent of human - induced pluripotent stem cell (hiPSC) technology has provided a unique opportunity to establish cellular models of disease from individual patients, and to study the effects of the underlying genetic aberrations upon multiple different cell types, many of which would not normally be accessible.

These findings have identified an alternative source of replacement tissue for use in human retinal cellular therapies, and provide a new in vitro cellular model system in which to study RPE diseases affecting human patients.

An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease.

The authors of the study explain that their findings suggest that ketogenic diets could also potentially help normalize pathological behaviors in the human model of schizophrenia by providing alternative energy sources via ketones, the products of fat breakdown, which would substitute the abnormally functioning cellular energy pathways in the brains of people suffering from this disease.

We know that the lemony aura of limonene is more than just a scent, as it can be found in our blood after exposure.8 Furthermore, several anticancer cellular pathways appear to be affected by the terpene limonene, leading some to suggest it has anticancer, or chemopreventative, benefits.9 While feeding it to rats in studies has revealed some efficacy against breast tumors, 10 we have a ways to go before we can make such bold claims in humans.

In contract with these biochemical research studies that examine events at a cellular level are studies on actual intake of soy foods by humans.

That being said, cellular mechanisms and animal studies are fun and exciting (to me anyway), but what you probably want to know if it leads to actual pounds lost when taken by humans.

Over the past decade, studies in a range of vertebrates, including humans, have begun to address the neural basis of attachment at a molecular, cellular and systems level.»