Sentences with phrase «human challenge trials»

The US National Institutes of Health was asked to fund so - called «human challenge trials», which would involve healthy volunteers being Read more about Ethical dilemma of studying Zika in humans - Scimex

Human challenge trials like this one are an extremely efficient way for scientists to tell whether a particular vaccine is effective, but they are rarely conducted because of the ethical dilemma of the risk it places on volunteers who are purposely exposed to a virus.

Stricter safety procedures and new ways to weaken pathogens to reduce their risks are leading investigators in industry, universities, and government to take a new look at human challenge trials, which offer a powerful tool for studying diseases and potential therapies.

In previous human challenge trials with this modified virus, Dr. Whitehead and his coinvestigators established the virus dose that would cause all recipients to develop viremia — the presence of virus in the blood — and most to develop a mild rash.

Not exact matches

Once the final results of those studies are analyzed this spring — and the early evidence has been encouraging — the challenge will be to get FDA approval for human trials and then bring the treatment to market.

By printing multiple lung airways — or any other afflicted organ — from a human patient and testing drugs on them, pharma companies can bypass the ethically challenged practice of testing on animals and proceed to human clinical trials with greater confidence the drugs will actually work, according to Wadsworth.

And scientists who conduct human challenge studies, which typically involve a few dozen participants, say they have critical benefits: In addition to saving time and money, they can reveal harm caused by a potential drug or vaccine before it enters large - scale human efficacy trials.

«Seattle BioMed's Malaria Clinical Trials Center is one of only four centers in the world approved to safely and effectively test new malaria treatments and vaccines in humans by the malaria human challenge model.

That could make it more challenging to get the therapy ready for human trials and Food and Drug Administration approval, Chen says.

As a firm that has met many therapeutic challenges, it is now beginning the first human trial for this rare liver disease.

Lastly, we need to move PfSEA -1-based vaccines into nonhuman primate challenge trials using human - use approved vaccine adjuvants.

Already, Graham said, VRC researchers have shown that passive immunization with VRC01, one of the broadest and most potent bNAbs identified in recent years, can protect rhesus macaques from virus challenge, adding that VRC01 is now ready to be used in human trials.

George Daley, MD, PhD, professor of hematology / oncology and director of the Stem Cell Transplantation Program at Boston Children's Hospital, says, «By confronting and ultimately solving the many regulatory challenges of a first - in - human trial, Dr. Takahashi has paved the way for all of us in the stem cell community to recognize the promise of iPS cells.»

The challenge takes on even more urgency with recent developments, including a federal administration now more open to exploring the potential of stem cells, the recent FDA approval of a human trial involving embryonic stem cells, as well as the reported case of a young boy who developed a brain tumor four years after receiving a stem - cell treatment for a rare genetic disorder.

A human Phase I / IIa malaria challenge trial of a polyprotein malaria vaccine.

Treating mice with anti-STAT5 drugs for a few weeks after they finished nursing their young lessened the elevated cancer risk, and so the next challenge is to see if this approach will also be effective in human clinical trials.

This figure, often fragmented, sometimes even completely abstracted, takes on various forms, from the human face, at once raw material and object of symbolic representation, as with Benglis's objectifying caresses, to the full body as place and tool of the trial and pleasure of repetition, as with Nauman's amateur choreography, bordering on the absurd, to the traces and physical prints left by the artist - creator (or the «art worker» in his service), as with the irregular random geometry of LeWitt, to the peers (Donald Judd) and tutelary figures in the history of art who inspire Flavin's evanescent structures... Now a disenchanted statement «Double Eye Poke» offers a challenge to the being of perception and thought.

Vriend then took the Alberta government and its Human Rights Commission to court, challenging the constitutionality of the IRPA, and winning at trial, but losing on appeal.

The European Court of Human Rights («ECtHR») has held that the use of telephone recordings as evidence in a criminal trial, despite the inability of the accused to challenge the caller, did not violate his rights under Article 6, ECHR.

Bank Mellat challenged the 2009 Order on the ground that it violated its rights under the European Convention on Human Rights, including its rights to property and right to a fair trial.

Appreciating just how difficult and challenging it is to work in the human resource department of an organization, I would like you to know that I am prepared for any trials that may come my way.

In particular, the Commission seeks leave to challenge as erroneous and inconsistent with the enunciated human rights standards the following aspects of the approach of the trial judge, Olney J, in finding that before the end of the 19th century the claimant group had ceased to acknowledge and observe traditional laws and customs: