Sentences with phrase «human clinical trials as»

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«Previous research, including human clinical trials, supports that diet beverages are an effective tool as part of an overall weight management plan.

The PhD course focuses on various aspects of human (donor) milk, with as main study a randomized clinical trial towards the effects of human donor milk in very low birth weight infants (the Early Nutrition Study).

«If you don't use as close to the total physiological system that you can, you're likely to run into troubles,» like being surprised by side effects later on in clinical trials, says William Haseltine, founder and former chairman and CEO of Rockville, Md. — based Human Genome Sciences.

The results, published online in the journal Brain, Behavior and Immunity, strengthen the case that transgenic Huntington's disease monkeys could be used to evaluate emerging treatments (such as this) before launching human clinical trials.

The team plans to move the CAR - T treatment into human clinical trials, but will build as many safeguards as possible into the trial to minimize risks to people who participate, Monje said.

Ishii notes that if the clinical trial begins as planned, it would be the latest in a series of firsts for China in the field of CRISPR gene editing, including the first CRISPR - edited human embryos, and the first CRISPR - edited monkeys.

«Computational models like this one might one day be able to predict the clinical course of a disease or injury, as well as make it possible to do less expensive testing of experimental drugs and interventions to see whether they are worth pursuing with human trials,» he said.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

In the newly reconstituted Scientific Responsibility, Human Rights, and Law Program, the missions of the CSFR and NCLS continue to complement one another as staff pursue projects such as continuing seminars for judges on neuroscience and the law, personalized medicine, the state and future of clinical trials, advocacy in science, understanding responsible research practices in changing research environments, and joint AAAS - China Association of Science and Technology workshops on science and ethics.

The researchers reprogrammed the cells to create induced pluripotent stem cells in an FDA - compliant facility at the Broad Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical trials.

Samuel Weiss, PhD, Professor and Director of the HBI, and Research Assistant Professor Artee Luchman, PhD, and colleagues, published their work today in Clinical Cancer Research, which is leading researchers to start a human phase I / II clinical trial as early as SpriClinical Cancer Research, which is leading researchers to start a human phase I / II clinical trial as early as Spriclinical trial as early as Spring 2015.

Since L - arginine can be given to women as a simple, safe, and inexpensive food supplement, (in peanuts, for example) in pregnancy, Dr. Kain and Dr. McDonald are now planning human clinical trials to assess its impact on human birth outcomes.

But sometime within the next few years, Min and Rhee plan to run clinical trials in humans to see whether FlaB - enhanced bacteria could work as a safe, effective anticancer therapy.

Bristol - Myers Squibb won its citation «for extending and enhancing human life through innovative pharmaceutical research and development, and for redefining the science of clinical study through groundbreaking and extremely complex clinical trials that are now recognized as industry models.»

As they develop human clinical trials, Wargo and colleagues also are conducting lab and mouse model research to better understand the mechanisms that connect bacteria and the immune system.

Further testing and human clinical trials are needed to determine if favipiravir, also known as T - 705 and Avigan, could effectively treat Lassa virus infection in people.

This is the first randomised clinical trial using as a research tool a high - fidelity simulation mannequin with a physiological response as a human being, a medical vehicle and volunteering healthcare practitioners from the Alicante Health Emergency Service (SES).

«Our next step is to see how long we can extend the cycling pattern, and test some of the STAT3 inhibitors currently in clinical trials for other indications such as cancer, as this could accelerate testing in humans,» added Sacco.

DFMO is being investigated in human clinical trials to treat some types of cancer, but it hasn't been tested as a potential therapy for Alzheimer's.

Now there is a need for clinical trials with humans in order to verify its safety as an adjuvant in the treatment of leishmaniasis.

The research, part of a phase I clinical trial to test the safety of the treatment, was published as a letter to the editor in The New England Journal of Medicine earlier this week and will be in the September issue of Human Gene Therapy.

To set up a clinical trial for humans takes time and resources, and doubly so in a country whose social and political fabric is as frayed as Liberia's.

iBET's infrastructure comprises 16 laboratories fully equipped with state - of - the - art technology (70 m2 each), including a BSL2 laboratory for working with viruses; a GMP Analytical Services Unit certified by the INFARMED (the Portuguese medicines authority, EMA Portuguese branch) and by DGAV (the Portuguese veterinary authority) for quality control and batch release of human and veterinary pharmaceuticals, biopharmaceuticals as well as experimental new drugs; a GMP Mass - Spectroscopy Unit that provides state - of - the - art MS services to the scientific community and Industry; a 2600 m2 bio-pilot plant supporting production and purification of proteins ATMPs and vaccines from bench top to 300 L scale and privileged access to GeniBET Biopharmaceuticals, an iBET spin - off producing ATMPs under cGMP certification for phase I / II / III clinical trials.

Findings from basic research, such as studies of cancer cells in the laboratory, can ultimately define research questions to study in humans, such as helping to identify drugs to test in clinical trials.

These results could pave the way for the use of progesterone against glioblastoma in a human clinical trial, perhaps in combination with standard - of - care therapeutic agents such as temozolomide.

A new cancer drug, known as BLU - 667, has shown promise in human clinical trials (Credit: vitanovski / Depositphotos)

The Human Trial is following one research team and a handful of trial patients as they move from the lab through the first two years of the Phase 1/2 clinical tTrial is following one research team and a handful of trial patients as they move from the lab through the first two years of the Phase 1/2 clinical ttrial patients as they move from the lab through the first two years of the Phase 1/2 clinical trialtrial.

NGF is in fact viewed as a viable target for AD clinical trials with one group investigating NGF ex vivo gene delivery in a Phase 1 trial with human patients aimed at stimulating cholinergic function and improving memory [123].

The aim of this clinical trial is to replicate in humans the same results observed in mice and, ultimately, lead to an effective, nontoxic treatment for newly diagnosed patients as well as patients who can no longer benefit from conventional treatments.

«The study did not investigate «microbe - mediated therapies» in humans and the claim that such treatments «may be safe and effective» is simply appended as a claim not only to clinical relevance, but to therapeutic benefit, before even the most preliminary of trials.»

Currently, only humans with serious illnesses can be injected with genes as part of a clinical trial.

Clinicians and investigators in the fields of veterinary and human endocrine oncology, clinical trials, pathology, and drug development will be joined in this consortium, in order to improve knowledge, development of, and access to naturally occurring canine endocrine tumours, as a model for human disease.

But, he notes that it will be necessary to perform well - designed clinical trials that test the safety and efficacy of high - grade NMN in humans before making the leap to using NMN (or perhaps its analogs) as pharmacotherapeutic agents.

«Our next goal is to replicate these experiments and test their safety in larger mammals, such as pigs, before considering clinical trials in humans,» added Dr. Srivastava, who is also a professor at the University of California, San Francisco (UCSF), with which Gladstone is affiliated.

As a result, when new uses for those drugs are identified, they can move to human clinical trials much faster.

In 2005, Dan co-founded and served as President and CEO of Inviragen Inc., which he transformed from a virtual start - up to a global clinical stage company with sites in Colorado, Wisconsin and Singapore and translated two vaccines from the research bench to human clinical trials, including one for dengue fever.

In addition to preventive vaccines, such as Gardasil and Cervarix, laboratory research and several human clinical trials are focused on the development of therapeutic HPV vaccines.

Monkey studies will not necessarily reproduce the same results as superior human clinical trials, however, O'Rand noted that they are probably as good a model as possible.

«If the findings are supported by future clinical trials in humans, then voluntary exercise could be considered as a way to improve the intellectual functioning of these children.»

Dr. Falk is also PI of an NIH, pharma, and philanthropic funded translational research laboratory group at CHOP that investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans, zebrafish, mouse, and human tissue models of genetic - based respiratory chain dysfunction, and directs multiple clinical treatment trials in mitochondrial disease patients.

As a next step, the researchers hope to investigate the proteins» roles in animal models before potentially pursuing clinical trials in humans.

«Our work in NPC1 mice may help lead to human clinical trials and eventually FDA approval for gene therapy as a treatment for NPC1 disease,» said Charles P. Venditti, M.D., Ph.D., senior investigator in the NHGRI Medical Genomics and Metabolic Genetics Branch.

As we produce more human - relevant data with our Organ - Chips, we look forward to making a positive impact on informing R&D decisions, reducing drug candidate attrition in human clinical trials, and helping to deliver better and safer medicines to patients.»

This makes many proponents talk about this CR as if it were a sure - thing, already proven through double - blind randomized clinical human trials.

As of June 2015, there were 116 clinical trials evaluating the possible anti-disease effect of curcumin in humans, including studies on cancer, gastrointestinal diseases, cognitive disorders, and psychiatric conditions.

While not conclusive, such outcomes should be used as background for forming hypotheses for the conduct of human clinical trials.

Kiran is currently involved in 7 novel human clinical trials on probiotics and the human microbiome and has extensive knowledge of the latest science on the human microbiome as it relates to health and wellness.

«Alternate - day fasting» searches identified 46 articles, of which 18 were in humans and 7 were labeled as clinical trials.

Whereas the few randomized controlled trials and observational clinical outcomes studies support the existence of a health benefit from fasting, substantial further research in humans is needed before the use of fasting as a health intervention can be recommended.

A few human clinical trials have examined the effects of pulse «extracts» taken as a dietary supplement on body weight and related parameters.