Sentences with phrase «human cohesin»
Because of its pleiotropic functions, defects in human cohesin biology can cause a number of clinically relevant issues.
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His research currently focuses on determining the mechanisms and consequences of cohesin gene inactivation in human cancer.
More specifically, we have been studying the roles of the condensin and cohesin complexes in 3D genome organization in the fission yeast, mouse and human systems.
By combining the fission yeast, mouse, and human systems with the latest genomic, genetic, cell biological, and biochemical approaches, we seek to determine how condensin and cohesin organize the functional 3D genome structures and participate in various biological processes, including transcriptional regulation and chromosomal dynamics, and how they contribute to oncogenic processes.