Sentences with phrase «human condensin»
We have shown that the human condensin complex functions in global 3D genome reorganization during the important process of cellular senescence (Yokoyama et al..
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This type of yeast shares many important genes with us and also has one of the two known condensin complexes in humans.
Where the second type of condensin, which is present in humans and other multicellular organisms, binds during cell division is another future line of inquiry.
Condensin expression in non-senescent human cell (left) induces senescence and completely transforms global genome architecture (right), which is referred to as Senescence - Associated Heterochromatic Foci (SAHF).
More specifically, we have been studying the roles of the condensin and cohesin complexes in 3D genome organization in the fission yeast, mouse and human systems.
By combining the fission yeast, mouse, and human systems with the latest genomic, genetic, cell biological, and biochemical approaches, we seek to determine how condensin and cohesin organize the functional 3D genome structures and participate in various biological processes, including transcriptional regulation and chromosomal dynamics, and how they contribute to oncogenic processes.