Sentences with phrase «human disorders»

The technique has already produced more than 500 different models of human disorders, including cardio - vascular diseases, diabetes and cancer.

In 1974 he began to investigate the role of nutrition in human disorders and began to incorporate that knowledge into his medical practice.

This innovative model allows the researchers to test viable new drugs for this disease, and it provides a potential solution to studying other human disorders of aging in mice.

Scientists are linking genes to a host of complex human disorders and traits, but just how valid — and useful — are these findings?

Unlike most other human disorders, it severely affects two individuals — the mother and the infant.

Secreted RNAs have already been shown to be involved in cell - cell communication between different tissues / organs and to serve as biomarkers for human disorders, such as cancer.

Animal gait is affected in models of human disorders such as Parkinson's Disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, spinal cord injury and many others.

«The knowledge gained will help us understand many human disorders caused by malfunctions of gene regulation, a major goal of the NIH and of our new Institute for Genomics and Systems Biology in Chicago» White said.

«This is the first human disorder associated with the gene CLP1,» said Dr. Ender Karaca, post-doctoral associate in the department of molecular and human genetics at Baylor.

The Sive group uses zebrafish to study the genetic / phenotype connections associated with human disorders.

The study, funded by the NIH / NIAAA, also demonstrates the great potential value of preclinical studies for understanding human disorders.

However, noncoding RNAs are emerging as important regulators of diverse cellular processes with implications for numerous human disorders.

The work also highlights the promise of iPSC technology as a discovery tool in understanding and treating human disorders.

Scientists have studied microcephaly in mice to better understand the condition in humans, but learning about human disorders from mice can be tricky.

He and other researchers will now use TRN manipulation in mice whose brains mimic human disorders.

Not so long ago, the advent of powerful genomic tools and genetic engineering techniques made it seem that studies involving mice engineered to carry human disease genes would be the best approach for exploring human disorders, superior to looking at cells isolated in a laboratory.

While Pollard's research focuses on understanding the microbiome through bioinformatics and modeling, other projects study human disorders such as diabetes and asthma, the impact of the ocean and soil on climate change, and the influence of plants, animals, and water on food production.

Centrosome alterations (in number and / or structure) are known to compromise several cellular processes and are associated with several human disorders.

The progress of high - throughput postgenomic technologies has led to better understanding of human disorders at the molecular level.

These flaws, called epithelial barrier defects, feature in human disorders, including in the skin, gut, and lung.

«Alzheimer's, like many human disorders, has a genetic component, yet many environmental and lifestyle factors contribute to the disease as well,» says Silverman.

«Previously, genome - wide screens were only possible in lower animals, such as flies, worms and yeast, where it is often difficult to assess the relevance to human disorders such as cancer.»

However, they say the work at least proves the potential for mRNA therapy to successfully treat not only hemophilia B but also other human disorders, such as hemophilia A (caused by faulty clotting factor VIII) or a variety of diseases of the liver, central nervous system, lung and eyes.

«This knowledge might in the long - term contribute to the understanding of the underlying mechanisms of human disorders of the nervous system that lead to loss of movement coordination, such as Parkinson's disease.»

«We hope the mouse PANDAS model can help refine the diagnostics for the human disorder,» Hornig says.

Lee says that although he doesn't know of any human disorders that are associated with the loss of p75 in particular, pain sensation is obviously vital for quality of life.

Mutations in a gene called progranulin (GRN) are commonly associated with frontotemporal dementia, but GRN mutations in mice do not mimic all the features of the human disorder, which has limited progress in the development of effective treatments.

The condition is considered a good animal model for OCD, and it's similar to the human disorder trichotillomania, where people pull out their own hair.

The protein mTOR regulates cell growth and metabolism and thus plays a key role in the development of human disorders.

«To our knowledge, this is the first robust mouse model of bipolar disorder based on a genome - wide significant risk factor for the human disorder.»

«We've realized they are actually a good model of human disorders and development,» Dr. Kurrasch said.

Researchers have unraveled the molecular basis of many human disorders, and a very large part (over 80 percent) of the genes we know to be associated with human disease (e.g. Parkinson's and addiction) have homologues in zebrafish.

Goal: Characterisation of mouse models for human diseases to understand molecular mechanisms of human disorders and for the development of new therapies

Deciphering the place of centrosome dysfunctions in the etiology of human disorders is an active field of fundamental research investigation and one of our main interests.

Nurr1 represents a potential drug target for associated human disorders, so the lab is exploring promising drug candidates targeting Nurr1 that could potentially slow down PD progression in a mechanism - based and neuroprotective manner.

Non-physiological alterations in chromosome number are well - established contributors to human disorders: they are responsible of a high percentage of miscarriages and a panel of diseases including Down syndrome, developmental disorders and cancer.

Can environmental toxins disrupt circadian rhythms — the biological «clock» whose disturbance is linked to chronic inflammation and a host of human disorders?

Furthermore, the heterozygous knock in mouse serves as a better animal model of the human disorder, as compared to the homozygous mouse, given that Huntington disease homozygosity is very rare in humans.

The hope is that such studies in Drosophila will one day clarify the role neurexin plays in learning and memory, ultimately leading to a better understanding of how defects in this protein can lead to human disorders such as autism, Bhat said.

Nurix is focused on discovering and developing therapies that modulate the ubiquitin proteasome system (UPS) for the treatment of a broad range of human disorders, most notably cancer.

These procedures generate animals that carry specific genetic alterations, and recreate the underlying cause of a human disorder or uncover the role of any gene of interest.

I accepted myself in all my human disorder.

We note that the standard for showing utility for a compound as a pharmaceutical before the patent office is much lower than that before the FDA, and that a human clinical trial is not necessary to establish utility for an invention related to treatment of human disorders.