Sentences with phrase «human donor cells»

In human donor cells and mouse experimental models, the researchers demonstrated that TSLP specifically targeted neutrophils — white blood cells that constitute the first line of defense against bacterial infections.

Not exact matches

Potential donors must also have blood drawn to test for HIV, HTLV (human T - cell lymphotropic virus), Syphilis, Hepatitis B, and Hepatitis C.

To estimate the prevalence of positive serology among potential donors to a human milk bank.Retrospective review of our experience with donor serological testing at our milk bank over a 6 - year interval.Not - for - profit, regional human milk bank.Volunteer, unpaid potential donors of human milk.Serological testing for syphilis, HIV, hepatitis B, hepatitis C, human T cell lymphotropic virus type 1 (HTLV - 1) and human T cell lymphotropic virus type 2 (HTLV - 2).

Donors should be tested for HIV 1 and 2, Human T - cell lymphotropic virus or HTLV 1 and 2, syphilis, and hepatitis B and C.

The team also tested nanoparticle absorption for other kinds of human cells, including fibroblasts from donors of older ages and found significant differences.

The researchers added human bone marrow stem cells from a non-diabetic donor to a bone fracture in laboratory pre-clinical studies.

For the derivation and use of ES cells, there must be informed consent from the donors of surplus human embryos, gametes, or cells.

In addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.

In humans, a comparison of bone marrow from 14 normal bone marrow donors, 35 multiple myeloma patients and 11 patients with a noncancerous condition called monoclonal gammopathy of undetermined significance (MGUS) showed that Runx2 levels were significantly higher in the multiple myeloma cells.

To test their hypothesis, the researchers harvested dermal papillae from seven human donors and cloned the cells in tissue culture; no additional growth factors were added to the cultures.

McCain would ban scientists from using donor eggs to create disease - specific stem cell lines or chimeric animals to see how human stem cells behave during development.

Groups planning to derive human ES cells still need both institutional and national reviews of their plans and there are strict requirements for informed consent by embryo donors.

Stem cell advocates have been expressing serious worry that ethical requirements spelled out in the draft guidelines — in particular, informed consent procedures for embryo donors — will rule out the use of many existing human embryonic stem cell lines, including the 21 lines approved under the Bush Administration.

«We studied human T cells, isolated from blood donors of all ages, to compare mature cytotoxic T cells with naive ones,» said Philip Ansumana Hull, graduate student in Ott's lab and one of the first authors of the study.

In May 2006, Eggan's lab received approval from Harvard to seek healthy human eggs from female donors, a first step toward using research cloning to create new stem cell lines.

After collecting biopsies from banked human donor eyes, the team expanded the numbers of cells in a culture plate using human serum to nourish them.

Researchers have long used a different monkey species to research stem cell transplants, but that species» biological characteristics means it can't be reliably used to find good donor matches to mimic human stem transplants.

Organ transplantation is a challenge, requiring immunosuppressive drugs and careful matching of donor and recipient for human leukocyte antigen markers, receptors on immune cells that recognize foreign proteins.

A year after receiving approval to study cloning in human cells, «we have yet to find a woman who's willing to participate as an egg donor,» he says.

Prins took human prostate stem cells from deceased young adult male organ donors and implanted the cells into mice, where they formed human prostate tissue.

A series of biological analyses of the mice with Tim - 1 and immune cells isolated from human donors showed that Ebola virus directly binds to T - cells through Tim - 1 protein binding and causes massive inflammation that thwarts the immune system.

«Our new approach takes young and aggressive macrophages from the bone marrow of a human donor and removes a key safeguard that cancer cells have co-opted to prevent them from being engulfed,» Alvey said.

Although this human Gut Chip recreated the villus epithelium of normal intestine and enabled new insights into how flow and cyclic peristalsis affects intestinal differentiation and function, it could not be used to study processes that relied on normal intestinal cells from individual donors, which, for example, is crucial for studying patient - specific responses for personalized medicine.

View the video A tiny cluster of lab - grown human cells that sprouts into liver tissue could one day nix the need for organ donors.

In further investigations of human liver cells from nearly 50 donor tissues of humans with varying degrees of body mass index (BMI) and liver fat, higher levels of CD8 + T cells were linked with higher levels of blood sugar or more advanced fatty liver disease.

To determine whether ZFN - mediated disruption of cxcr4 indeed protects CD4 + T cells from an in vitro HIV challenge, human CD4 + T cells from three different ccr5 wild type donors were stimulated and transduced with AdX4 - ZFNs or an AdR5 - ZFNs control.

However, Takebe's liver bud has the advantage of being grown from iPS cells, rather than, for example, the primary human hepatocytes used in Bhatia's graft, which could make it useful in modelling rare diseases or examining the specific genetic backgrounds of the iPS cell donors.

It is also pointed out that donor age (beyond 45 years in the alkaline phosphatase - linked BrdU assays) may also have limited the human wounding response (cell division) in the corneal periphery.

We handle cells derived from two species (human and dog) and from healthy donors and individuals affected by neuromuscular diseases.

Human epidermis has been produced in vitro for decades using adult epidermal stem cells from donors to provide cell therapy.

In work reported in the journal PLoS One in June, the scientists compared healthy human beta cells from surgical donors with beta cells that had been transplanted into mice with suppressed immune systems.

Donor - derived mesenchymal stem cells remain present and functional in the transplanted human heart.

Differential osteogenicity of multiple donor - derived human mesenchymal stem cells and osteoblasts in monolayer, scaffold - based 3D culture and in vivo.

GigaGen captured millions - diverse DNA libraries from B cell and plasma cell repertoires from human donors and used these libraries to manufacture recombinant IgG proteins.

He has developed novel cellular models of neurological diseases (schizophrenia, MS, autism, Alzheimer's, Parkinson's) using human induced pluripotent stem cells (iPSCs) derived from donor patients and differentiated to specific neuronal cell types.

Fetal tissue is treated as the mother's tissue, and is governed by the consent provisions of the Human Tissue Act which regulates the storage and use of tissues and cells from living donors.

We developed and implemented such a nomenclature for the European human pluripotent stem cell registry (hPSCreg), which needs to: 1) unambiguously identify a registered cell line; 2) allow tracing of subclones of a particular line; and 3) enable the assignment of different lines to a specific donor origin.

Natsume, Toyoaki, et al. «Rapid Protein Depletion in Human Cells by Auxin - Inducible Degron Tagging with Short Homology Donors.»

(B) High power image showing pigment granule - containing donor cells in the RPE - L region that are positive for human nuclear marker (arrows).

In the case of the human - cow embryo, the «donor egg» is the cow's egg, and the «patient's cell» could be something like a skin cell.

Given the critical shortage of donor organs to replace those damaged by accident or disease, it has long been a goal of science to create human organs from stem cells.

Scientists in Japan said Wednesday they had grown human liver tissue from stem cells in a first that holds promise for alleviating the critical shortage of donor organs.

Patients receive one of two types of stem cell - based transplants: autologous, in which a patient donates and receives back his / her own stem cells; or allogeneic, in which bone marrow - derived stem cells come from a related or unrelated donor whose human leukocyte antigens (HLA) are genetically matched with those of a patient.

She gained expertise in human immunology during her post-doctoral training at Blood System Research Institute while working on T cell responses to West Nile virus (WNV) in blood donors.

The reprogramming strategy described here revealed a potential transcriptional signature for human iPSCs yet retaining the gene expression of donor cells in human reprogrammed cells free of viral and transgene interference.

U.S. Military HIV Research Program (MHRP) researchers, however, have demonstrated that essentially all of the infectious virus particles can bind to the surface of red blood cells isolated from each of 30 normal (non-infected) human donors.

Shier LR, Schultz KR, Imren S, Regan J, Issekutz A, Sadek I, Gilman A, Panzarella T, Eaves CJ, Couban S. Differential Effects of G - CSF on Marrow and Blood - Derived Hematopoietic and Immune Cell Populations in Healthy Human Donors.

We suggest correct identification of the origin of these cells (using human specific markers, which define cell membranes) is essential in order to distinguish viable donor cells from host inflammatory cells which have engulfed transplanted cells.

We observed that this pathogenic process was active in human islet cells obtained from donors with type 2 diabetes... [7]

Our writer investigates the benefits of using skin care products that contain plant - derived stem cells — and non-embryonic human cells extracted from consenting egg donors (seriously).