Congressional supporters of stem cell research have re-introduced legislation to codify President Barack Obama's 2009 executive order lifting restrictions on the number
of human embryonic stem cell lines available to federally funded researchers.
He has also been an inveterate foe of abortion, a position that informed his repeated votes against expanding the number of
human embryonic stem cell lines available to NIH - funded researchers during the George W. Bush administration.
In the United States, embryonic stem cell isolation is not permitted using federal funds; however, since August 2001, the Bush government accepted registration of 78
human embryonic stem cell lines on which research could be carried out using government finance.
«Using a human embryonic stem cell assay, Dieter Egli's lab shows that the majority of
human embryonic stem cell lines established following spindle transfer retain similar levels of mitochondrial carryover (heteroplasmy) to that detected in the preimplantation embryo.
Using pre-implantation genetic diagnosis
derived human embryonic stem cell lines (hES) or human induced pluripotent stem cells carrying the causal mutation for neuro - muscular diseases, our objective is double: identify new physiopathogical mechanisms and develop new therapeutic strategies.
«Basically, this study shows that the genetic makeup of
individual human embryonic stem cell lines is unique in the numbers of copies of certain genes that may control traits and things like disease susceptibility,» said Teitell, who also is an associate professor of pathology and laboratory medicine and a researcher at UCLA's Jonsson Comprehensive Cancer Center.
Stem cell advocates have been expressing serious worry that ethical requirements spelled out in the draft guidelines — in particular, informed consent procedures for embryo donors — will rule out the use of many
existing human embryonic stem cell lines, including the 21 lines approved under the Bush Administration.
One caveat is that the authors also observed that one of the eight
human embryonic stem cell lines established following spindle transfer showed a drift in mitochondrial heteroplasmy in a subset of stem cells, despite low levels of carryover detected in the embryo.
His current research interests include developing morphologic and biologic markers of embryo viability in order to enable single embryo transfer and avoid multiple pregnancies; optimizing preimplantation genetic testing; and
deriving human embryonic stem cell lines.
They used the gene editing technology CRISPR to engineer a series
of human embryonic stem cell lines, which were identical apart from the number of DNA repeats that occurred at the ends of their HTT genes.
Korean researcher Woo Suk Hwang claimed in 2004 to have created
a human embryonic stem cell line using a technique called somatic cell nuclear transfer (SCNT).
Obama and Clinton both voted for the Stem Cell Research Enhancement Act, which would have broadly extended federal funding to
human embryonic stem cell lines but was vetoed by Bush in 2006 and 2007.
What Collins does not say, however, is that the new NIH guidelines also allow for federal funds to be used in studying new
human embryonic stem cell lines that are created (by private entities, of course) beyond the 700 currently in existence.
Stem cell researchers from UCLA used a high resolution technique to examine the genome, or total DNA content, of a pair of
human embryonic stem cell lines and found that while both lines could form neurons, the lines had differences in the numbers of certain genes that could control such things as individual traits and disease susceptibility.
Not only is it possible to create hESC lines without destroying a human embryo, and not only does each blastocyst provides a potentially infinite number of cells for research, but most researchers who work with
these human embryonic stem cell lines never encounter donated human embryos, just the lines generated from them.
In April 2004, more than 200 members of the U.S. House of Representatives sent President Bush a letter, asking him to increase the number of
human embryonic stem cell lines that should be eligible for public funding.
In addition the Institute uses induced pluripotent stem cells and
human embryonic stem cell lines.
The National Institutes of Health is set to announce the approval of four
human embryonic stem cell lines that were eligible for federal funding under former US President George W. Bush, but originally deemed ineligible under new rules from the current administration.
In April of 2004, a letter bearing 206 signatures of Members of the United States House of Representatives was sent to President George Bush, asking him to increase the number of
human embryonic stem cell lines that should be eligible for public funding.